Imperial College London
Alternate

ProfessorElioRiboli

Faculty of Medicine, School of Public Health

Chair in Cancer Epidemiology and Prevention
 
 
 
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Contact

 

e.riboli Website CV

 
 
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Assistant

 

Ms Julieta Dourado +44 (0)20 7594 3426

 
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Location

 

152Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Aune:2017:ije/dyw319,
author = {Aune, D and Giovannucci, E and Boffetta, P and Fadnes, LT and Keum, N and Norat, T and Greenwood, DC and Riboli, E and Vatten, LJ and Tonstad, S},
doi = {ije/dyw319},
journal = {International Journal of Epidemiology},
pages = {1029--1056},
title = {Fruit and vegetable intake and the risk of cardiovasculardisease, total cancer and all-cause mortality – a systematicreview and dose-response meta-analysis of prospectivestudies},
url = {http://dx.doi.org/10.1093/ije/dyw319},
volume = {46},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Questions remain about the strength and shape of the dose response relationship between fruit and vegetable intake and risk of cardiovascular disease, cancer and mortality, and the effects of specific types of fruit and vegetables. We conducted a systematic review and meta analysis to clarify these questions.  Methods and Results: PubMed and Embase were searched up to 29th of September 2016. Prospective studies of fruit and vegetable intake and cardiovascular disease, total cancer and all cause mortality were included. Summary RRs were calculated using a random effects model and the mortality burden globally was estimated. Ninety five studies (142 publications) were included. For fruits and vegetables combined, the summary RR per 200 g/day was 0.92 (95% CI: 0.90 0.94, I2=0%, n=15) for coronary heart disease, 0.84 (95% CI: 0.76 0.92, I2=73%, n=10) for stroke, 0.92 (95% CI: 0.90 0.95, I2=31%, n=13) for cardiovascular disease, 0.97 (95% CI: 0.95 0.99, I2=49%, n=12) for total cancer, and 0.90 (95% CI: 0.87 0.93, I2=83%, n=15) for all cause mortality. Similar associations were observed for fruits and vegetables separately. Reductions in risk were observed up to 700 800 g/day for all outcomes except cancer (600 g/day). Inverse associations were observed between apples or pears, citrus fruits, green leafy vegetables, cruciferous vegetables, and salads and cardiovascular disease and mortality, and between green yellow vegetables and cruciferous vegetables and total cancer risk. An estimated 5.6 and 7.8 million premature deaths worldwide in 2013 may be attributable to a fruit and vegetable intake below 500 and 800 grams per day, respectively.  Conclusion: Fruits and vegetable intakes were associated with reduced risk of cardiovascular disease, cancer and mortality. These results supports public health recommendations to increase fruit and vegetable intake for chronic disease prevention.
AU  - Aune,D
AU  - Giovannucci,E
AU  - Boffetta,P
AU  - Fadnes,LT
AU  - Keum,N
AU  - Norat,T
AU  - Greenwood,DC
AU  - Riboli,E
AU  - Vatten,LJ
AU  - Tonstad,S
DO  - ije/dyw319
EP  - 1056
PY  - 2017///
SN  - 1464-3685
SP  - 1029
TI  - Fruit and vegetable intake and the risk of cardiovasculardisease, total cancer and all-cause mortality – a systematicreview and dose-response meta-analysis of prospectivestudies
T2  - International Journal of Epidemiology
UR  - http://dx.doi.org/10.1093/ije/dyw319
UR  - http://hdl.handle.net/10044/1/42020
VL  - 46
ER  -
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