Imperial College London
Alternate

ProfessorElioRiboli

Faculty of Medicine, School of Public Health

Chair in Cancer Epidemiology and Prevention
 
 
 
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Contact

 

e.riboli Website CV

 
 
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Assistant

 

Ms Julieta Dourado +44 (0)20 7594 3426

 
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Location

 

152Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fedirko:2019:10.3390/nu11040935,
author = {Fedirko, V and Jenab, M and Meplan, C and Jones, JS and Zhu, W and Schomburg, L and Siddiq, A and Hybsier, S and Overvad, K and Tjonneland, A and Omichessan, H and Perduca, V and Boutron-Ruault, M-C and Kuehn, T and Katzke, V and Aleksandrova, K and Trichopoulou, A and Karakatsani, A and Kotanidou, A and Tumino, R and Panico, S and Masala, G and Agnoli, C and Naccarati, A and Bueno-de-Mesquita, B and Vermeulen, RCH and Weiderpass, E and Skeie, G and Nost, TH and Lujan-Barroso, L and Ramon, Quiros J and Maria, Huerta J and Rodriguez-Barranco, M and Barricarte, A and Gylling, B and Harlid, S and Bradbury, KE and Wareham, N and Khaw, K-T and Gunter, M and Murphy, N and Freisling, H and Tsilidis, K and Aune, D and Riboli, E and Hesketh, JE and Hughes, DJ},
doi = {10.3390/nu11040935},
journal = {Nutrients},
pages = {1--19},
title = {Association of sSelenoprotein and selenium pathway genotypes with risk of colorectal cancer and interaction with selenium status},
url = {http://dx.doi.org/10.3390/nu11040935},
volume = {11},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes. Illumina Goldengate assays were designed and resulted in the genotyping of 1040 variants in 154 genes from 1420 cases and 1421 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Multivariable logistic regression revealed an association of 144 individual SNPs from 63 Se pathway genes with CRC risk. However, regarding the selenoprotein genes, only TXNRD1 rs11111979 retained borderline statistical significance after adjustment for correlated tests (PACT = 0.10; PACT significance threshold was P < 0.1). SNPs in Wingless/Integrated (Wnt) and Transforming growth factor (TGF) beta-signaling genes (FRZB, SMAD3, SMAD7) from pathways affected by Se intake were also associated with CRC risk after multiple testing adjustments. Interactions with Se status (using existing serum Se and Selenoprotein P data) were tested at the SNP, gene, and pathway levels. Pathway analyses using the modified Adaptive Rank Truncated Product method suggested that genes and gene x Se status interactions in antioxidant, apoptosis, and TGF-beta signaling pathways may be associated with CRC risk. This study suggests that SNPs in the Se pathway alone or in combination with suboptimal Se status may contribute to CRC development.
AU  - Fedirko,V
AU  - Jenab,M
AU  - Meplan,C
AU  - Jones,JS
AU  - Zhu,W
AU  - Schomburg,L
AU  - Siddiq,A
AU  - Hybsier,S
AU  - Overvad,K
AU  - Tjonneland,A
AU  - Omichessan,H
AU  - Perduca,V
AU  - Boutron-Ruault,M-C
AU  - Kuehn,T
AU  - Katzke,V
AU  - Aleksandrova,K
AU  - Trichopoulou,A
AU  - Karakatsani,A
AU  - Kotanidou,A
AU  - Tumino,R
AU  - Panico,S
AU  - Masala,G
AU  - Agnoli,C
AU  - Naccarati,A
AU  - Bueno-de-Mesquita,B
AU  - Vermeulen,RCH
AU  - Weiderpass,E
AU  - Skeie,G
AU  - Nost,TH
AU  - Lujan-Barroso,L
AU  - Ramon,Quiros J
AU  - Maria,Huerta J
AU  - Rodriguez-Barranco,M
AU  - Barricarte,A
AU  - Gylling,B
AU  - Harlid,S
AU  - Bradbury,KE
AU  - Wareham,N
AU  - Khaw,K-T
AU  - Gunter,M
AU  - Murphy,N
AU  - Freisling,H
AU  - Tsilidis,K
AU  - Aune,D
AU  - Riboli,E
AU  - Hesketh,JE
AU  - Hughes,DJ
DO  - 10.3390/nu11040935
EP  - 19
PY  - 2019///
SN  - 2072-6643
SP  - 1
TI  - Association of sSelenoprotein and selenium pathway genotypes with risk of colorectal cancer and interaction with selenium status
T2  - Nutrients
UR  - http://dx.doi.org/10.3390/nu11040935
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000467749800228&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.mdpi.com/2072-6643/11/4/935
UR  - http://hdl.handle.net/10044/1/88211
VL  - 11
ER  -
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