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@article{Huang:2016:10.1002/ijc.30590,
author = {Huang, J and Zagai, U and Hallmans, G and Nyrén, O and Engstrand, L and Stolzenberg-Solomon, R and Duell, EJ and Overvad, K and Katzke, VA and Kaaks, R and Jenab, M and Young, Park J and Murillo, R and Trichopoulou, A and Lagiou, P and Bamia, C and Bradbury, KE and Riboli, E and Aune, D and Tsilidis, KK and Capellá, G and Agudo, A and Krogh, V and Palli, D and Panico, S and Weiderpass, E and Tjønneland, A and Olsen, A and Martínez, B and Redondo-Sanchez, D and Chirlaque, MD and Peeters, PHM and Regnér, S and Lindkvist, B and Naccarati, A and Ardanaz, E and Larrañaga, N and Boutron-Ruault, MC and Revours, V and Barré, A and Bueno-de-Mesquita, HB and Ye, W},
doi = {10.1002/ijc.30590},
journal = {International Journal of Cancer},
pages = {1727--1735},
title = {Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: a nested case-control study},
url = {http://dx.doi.org/10.1002/ijc.30590},
volume = {140},
year = {2016}
}

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TY  - JOUR
AB  - The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for matching factors and other potential confounders. Our results showed that pancreatic cancer risk was neither associated with H. pylori seropositivity (OR=0.96; 95% CI: 0.70, 1.31) nor CagA seropositivity (OR=1.07; 95% CI: 0.77, 1.48). We also did not find any excess risk among individuals seropositive for H. pylori but seronegative for CagA, compared with the group seronegative for both antibodies (OR=0.94; 95% CI: 0.63, 1.38). However, we found that chronic corpus atrophic gastritis was non-significantly associated with an increased pancreatic cancer risk (OR=1.35; 95% CI: 0.77, 2.37), and although based on small numbers, the excess risk was particularly marked among individuals seronegative for both H. pylori and CagA (OR=5.66; 95% CI: 1.59, 20.19, p value for interaction < 0.01). Our findings provided evidence supporting the null association between H. pylori infection and pancreatic cancer risk in western European populations. However, the suggested association between chronic corpus atrophic gastritis and pancreatic cancer risk warrants independent verification in future studies, and, if confirmed, further studies on the underlying mechanisms.
AU  - Huang,J
AU  - Zagai,U
AU  - Hallmans,G
AU  - Nyrén,O
AU  - Engstrand,L
AU  - Stolzenberg-Solomon,R
AU  - Duell,EJ
AU  - Overvad,K
AU  - Katzke,VA
AU  - Kaaks,R
AU  - Jenab,M
AU  - Young,Park J
AU  - Murillo,R
AU  - Trichopoulou,A
AU  - Lagiou,P
AU  - Bamia,C
AU  - Bradbury,KE
AU  - Riboli,E
AU  - Aune,D
AU  - Tsilidis,KK
AU  - Capellá,G
AU  - Agudo,A
AU  - Krogh,V
AU  - Palli,D
AU  - Panico,S
AU  - Weiderpass,E
AU  - Tjønneland,A
AU  - Olsen,A
AU  - Martínez,B
AU  - Redondo-Sanchez,D
AU  - Chirlaque,MD
AU  - Peeters,PHM
AU  - Regnér,S
AU  - Lindkvist,B
AU  - Naccarati,A
AU  - Ardanaz,E
AU  - Larrañaga,N
AU  - Boutron-Ruault,MC
AU  - Revours,V
AU  - Barré,A
AU  - Bueno-de-Mesquita,HB
AU  - Ye,W
DO  - 10.1002/ijc.30590
EP  - 1735
PY  - 2016///
SN  - 1097-0215
SP  - 1727
TI  - Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: a nested case-control study
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.30590
UR  - http://hdl.handle.net/10044/1/43238
VL  - 140
ER  -

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