Imperial College London
Alternate

ProfessorElioRiboli

Faculty of Medicine, School of Public Health

Chair in Cancer Epidemiology and Prevention
 
 
 
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Contact

 

e.riboli Website CV

 
 
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Assistant

 

Ms Julieta Dourado +44 (0)20 7594 3426

 
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Location

 

152Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Aune:2017:10.1007/s10654-017-0232-4,
author = {Aune, D and Sen, A and Schlesinger, S and Norat, T and Janszky, I and Romundstad, P and Tonstad, S and Riboli, E and Vattan, LJ},
doi = {10.1007/s10654-017-0232-4},
journal = {European Journal of Epidemiology},
pages = {181--192},
title = {Body mass index, abdominal fatness, fat mass and the risk of atrial fibrillation: a systematic review and dose–response meta-analysis of prospective studies},
url = {http://dx.doi.org/10.1007/s10654-017-0232-4},
volume = {32},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Different adiposity measures have been associ-ated with increased risk of atrial fibrillation, however,results have previously only been summarized for BMI.We therefore conducted a systematic review and meta-analysis of prospective studies to clarify the associationbetween different adiposity measures and risk of atrialfibrillation. PubMed and Embase databases were searchedup to October 24th 2016. Summary relative risks (RRs)were calculated using random effects models. Twenty-nineunique prospective studies (32 publications) were included.Twenty-five studies (83,006 cases, 2,405,381 participants)were included in the analysis of BMI and atrial fibrillation.The summary RR was 1.28 (95% confidence interval:1.20–1.38, I2=97%) per 5 unit increment in BMI, 1.18(95% CI: 1.12–1.25, I2=73%, n=5) and 1.32 (95% CI:1.16–1.51, I2=91%, n=3) per 10 cm increase in waistand  hip  circumference,  respectively,  1.09  (95%  CI:1.02–1.16, I2=44%, n=4) per 0.1 unit increase in waist-to-hip ratio, 1.09 (95% CI: 1.02–1.16, I2=94%, n=4)per 5 kg increase in fat mass, 1.10 (95% CI: 0.92–1.33,I2=90%, n=3) per 10% increase in fat percentage,1.10 (95% CI: 1.08–1.13, I2=74%, n=10) per 5 kgincrease  in  weight,  and  1.08  (95%  CI:  0.97–1.19,I2=86%, n=2) per 5% increase in weight gain. Theassociation between BMI and atrial fibrillation was non-linear,pnonlinearity\0.0001, with a stronger association athigher BMI levels, however, increased risk was observedeven at a BMI of 22–24 compared to 20. In conclusion,general and abdominal adiposity and higher body fat massincrease the risk of atrial fibrillation.
AU  - Aune,D
AU  - Sen,A
AU  - Schlesinger,S
AU  - Norat,T
AU  - Janszky,I
AU  - Romundstad,P
AU  - Tonstad,S
AU  - Riboli,E
AU  - Vattan,LJ
DO  - 10.1007/s10654-017-0232-4
EP  - 192
PY  - 2017///
SN  - 1573-7284
SP  - 181
TI  - Body mass index, abdominal fatness, fat mass and the risk of atrial fibrillation: a systematic review and dose–response meta-analysis of prospective studies
T2  - European Journal of Epidemiology
UR  - http://dx.doi.org/10.1007/s10654-017-0232-4
UR  - http://hdl.handle.net/10044/1/44302
VL  - 32
ER  -
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