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@article{Riboli:2017:10.1371/journal.pmed.1002409,
author = {Riboli, E},
doi = {10.1371/journal.pmed.1002409},
journal = {PLoS Medicine},
title = {A combination of plasma phospholipid fatty acids and incidence of type 2 diabetes:The EPIC-InterAct case-cohort study},
url = {http://dx.doi.org/10.1371/journal.pmed.1002409},
volume = {14},
year = {2017}
}

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TY  - JOUR
AB  - BackgroundCombinations of multiple fatty acids may influence cardiometabolic risk more than single fatty acids. The association of a combination of fatty acids with incident type 2 diabetes (T2D) has not been evaluated.Methods and findingsWe measured plasma phospholipid fatty acids by gas chromatography in 27,296 adults, including 12,132 incident cases of T2D, over the follow-up period between baseline (1991–1998) and 31 December 2007 in 8 European countries in EPIC-InterAct, a nested case-cohort study. The first principal component derived by principal component analysis of 27 individual fatty acids (mole percentage) was the main exposure (subsequently called the fatty acid pattern score [FA-pattern score]). The FA-pattern score was partly characterised by high concentrations of linoleic acid, stearic acid, odd-chain fatty acids, and very-long-chain saturated fatty acids and low concentrations of γ-linolenic acid, palmitic acid, and long-chain monounsaturated fatty acids, and it explained 16.1% of the overall variability of the 27 fatty acids. Based on country-specific Prentice-weighted Cox regression and random-effects meta-analysis, the FA-pattern score was associated with lower incident T2D. Comparing the top to the bottom fifth of the score, the hazard ratio of incident T2D was 0.23 (95% CI 0.19–0.29) adjusted for potential confounders and 0.37 (95% CI 0.27–0.50) further adjusted for metabolic risk factors. The association changed little after adjustment for individual fatty acids or fatty acid subclasses. In cross-sectional analyses relating the FA-pattern score to metabolic, genetic, and dietary factors, the FA-pattern score was inversely associated with adiposity, triglycerides, liver enzymes, C-reactive protein, a genetic score representing insulin resistance, and dietary intakes of soft drinks and alcohol and was positively associated with high-density-lipoprotein cholesterol and intakes of polyunsaturated fat, dietary fibre, and co
AU  - Riboli,E
DO  - 10.1371/journal.pmed.1002409
PY  - 2017///
SN  - 1549-1277
TI  - A combination of plasma phospholipid fatty acids and incidence of type 2 diabetes:The EPIC-InterAct case-cohort study
T2  - PLoS Medicine
UR  - http://dx.doi.org/10.1371/journal.pmed.1002409
UR  - http://hdl.handle.net/10044/1/50819
VL  - 14
ER  -

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