Publications

BibTex format

@article{van:2017:10.1002/ijc.31146,
author = {van, Duijnhoven FJB and Jenab, M and Hveem, K and Siersema, PD and Fedirko, V and Duell, EJ and Kampman, E and Halfweeg, A and van, Kranen HJ and van, den Ouweland JMW and Weiderpass, E and Murphy, N and Langhammer, A and Ness-Jensen, E and Olsen, A and Tjonneland, A and Overvad, K and Cadeau, C and Kvaskoff, M and Boutron-Ruault, M-C and Katzke, VA and Kuhn, T and Boeing, H and Trichopoulou, A and Kotanidou, A and Kritikou, M and Palli, D and Agnoli, C and Tumino, R and Panico, S and Matullo, G and Peeters, P and Brustad, M and Standahl, Olsen K and Lasheras, C and Obon-Santacana, M and Sanchez, M-J and Dorronsoro, M and Chirlaque, M-D and Barricarte, A and Manjer, J and Almquist, M and Renstrom, F and Ye, W and Wareham, N and Khaw, K-T and Bradbury, KE and Freisling, H and Aune, D and Norat, T and Riboli, E and Bueno-de-Mesquita, H},
doi = {10.1002/ijc.31146},
journal = {International Journal of Cancer},
pages = {1189--1201},
title = {Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations},
url = {http://dx.doi.org/10.1002/ijc.31146},
volume = {142},
year = {2017}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42–1.20); 0.94 (0.72–1.22); 1.12 (0.82–1.53) and 1.26 (0.79–2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.
AU  - van,Duijnhoven FJB
AU  - Jenab,M
AU  - Hveem,K
AU  - Siersema,PD
AU  - Fedirko,V
AU  - Duell,EJ
AU  - Kampman,E
AU  - Halfweeg,A
AU  - van,Kranen HJ
AU  - van,den Ouweland JMW
AU  - Weiderpass,E
AU  - Murphy,N
AU  - Langhammer,A
AU  - Ness-Jensen,E
AU  - Olsen,A
AU  - Tjonneland,A
AU  - Overvad,K
AU  - Cadeau,C
AU  - Kvaskoff,M
AU  - Boutron-Ruault,M-C
AU  - Katzke,VA
AU  - Kuhn,T
AU  - Boeing,H
AU  - Trichopoulou,A
AU  - Kotanidou,A
AU  - Kritikou,M
AU  - Palli,D
AU  - Agnoli,C
AU  - Tumino,R
AU  - Panico,S
AU  - Matullo,G
AU  - Peeters,P
AU  - Brustad,M
AU  - Standahl,Olsen K
AU  - Lasheras,C
AU  - Obon-Santacana,M
AU  - Sanchez,M-J
AU  - Dorronsoro,M
AU  - Chirlaque,M-D
AU  - Barricarte,A
AU  - Manjer,J
AU  - Almquist,M
AU  - Renstrom,F
AU  - Ye,W
AU  - Wareham,N
AU  - Khaw,K-T
AU  - Bradbury,KE
AU  - Freisling,H
AU  - Aune,D
AU  - Norat,T
AU  - Riboli,E
AU  - Bueno-de-Mesquita,H
DO  - 10.1002/ijc.31146
EP  - 1201
PY  - 2017///
SN  - 0020-7136
SP  - 1189
TI  - Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.31146
UR  - http://hdl.handle.net/10044/1/51440
VL  - 142
ER  -

Download

ProfessorElioRiboli

Contact

Assistant

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)