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@article{Butt:2018:10.1002/ijc.31283,
author = {Butt, J and Jenab, M and Willhauck-Fleckenstein, M and Michel, A and Pawlita, M and Kyro, C and Tjønneland, A and Boutron-Ruault, M-C and Carbonnel, F and Severi, G and kaaks, R and Kuhn, T and Boeing, H and Trichopoulou, A and la, Vecchia C and Karakatsani, A and Panico, S and Tumino, R and Agnoli, C and Palli, D and Sacerdote, C and Bueno-de-Mesquita, B and Weiderpass, E and Sánchez, M-J and Bonet, C and Murphy, N and Freisling, H and Riboli, E and Tsilidis, K and Aune, D and Waterboer, T and Hughes, D},
doi = {10.1002/ijc.31283},
journal = {International Journal of Cancer},
pages = {245--252},
title = {Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer},
url = {http://dx.doi.org/10.1002/ijc.31283},
volume = {143},
year = {2018}
}

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TY  - JOUR
AB  - The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG). However, it is unclear whether the association is also present prediagnostically. We assessed the association of antibody responses to SGG proteins in prediagnostic serum samples with CRC risk in a case–control study nested within a prospective cohort. Prediagnostic serum samples from 485 first incident CRC cases (mean time between blood draw and diagnosis 3.4 years) and 485 matched controls in the European Prospective Investigation into Nutrition and Cancer (EPIC) study were analyzed for antibody responses to 11 SGG proteins using multiplex serology. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable conditional logistic regression models. Antibody positivity for any of the 11 SGG proteins was significantly associated with CRC risk with 56% positive controls compared to 63% positive cases (OR: 1.36, 95% CI: 1.04–1.77). Positivity for two or more proteins of a previously identified SGG 6marker panel with greater CRCspecificity was also observed among 9% of controls compared to 17% of CRC cases, corresponding to a significantly increased CRC risk (OR: 2.17, 95% CI: 1.44–3.27). In this prospective nested case–control study, we observed a positive association between antibody responses to SGG and CRC development in serum samples taken before evident disease onset. Further work is required to establish the possibly etiological significance of these observations and whether SGG serology may be applicable for CRC risk stratification.
AU  - Butt,J
AU  - Jenab,M
AU  - Willhauck-Fleckenstein,M
AU  - Michel,A
AU  - Pawlita,M
AU  - Kyro,C
AU  - Tjønneland,A
AU  - Boutron-Ruault,M-C
AU  - Carbonnel,F
AU  - Severi,G
AU  - kaaks,R
AU  - Kuhn,T
AU  - Boeing,H
AU  - Trichopoulou,A
AU  - la,Vecchia C
AU  - Karakatsani,A
AU  - Panico,S
AU  - Tumino,R
AU  - Agnoli,C
AU  - Palli,D
AU  - Sacerdote,C
AU  - Bueno-de-Mesquita,B
AU  - Weiderpass,E
AU  - Sánchez,M-J
AU  - Bonet,C
AU  - Murphy,N
AU  - Freisling,H
AU  - Riboli,E
AU  - Tsilidis,K
AU  - Aune,D
AU  - Waterboer,T
AU  - Hughes,D
DO  - 10.1002/ijc.31283
EP  - 252
PY  - 2018///
SN  - 0020-7136
SP  - 245
TI  - Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.31283
UR  - http://hdl.handle.net/10044/1/56441
VL  - 143
ER  -

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