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@article{Li:2018:10.1007/s00125-018-4586-2,
author = {Li, SX and Imamura, F and Schulze, MB and Zheng, J and Ye, Z and Agudo, A and Ardanaz, E and Aune, D and Boeing, H and Dorronsoro, M and Dow, C and Fagherazzi, G and Grioni, S and Gunter, MJ and Huerta, JM and Ibsen, DB and Jakobsen, MU and Kaaks, R and Key, TJ and Khaw, K-T and Kyrø, C and Mancini, FR and Molina-Portillo, E and Murphy, N and Nilsson, PM and Onland-Moret, NC and Palli, D and Panico, S and Poveda, A and Quirós, JR and Ricceri, F and Sluijs, I and Spijkerman, AMW and Tjonneland, A and Tumino, R and Winkvist, A and Langenberg, C and Sharp, SJ and Riboli, E and Scott, RA and Forouhi, NG and Wareham, NJ},
doi = {10.1007/s00125-018-4586-2},
journal = {Diabetologia},
pages = {1325--1332},
title = {Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries},
url = {http://dx.doi.org/10.1007/s00125-018-4586-2},
volume = {61},
year = {2018}
}

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TY  - JOUR
AB  - AIMS/HYPOTHESIS: Gene-macronutrient interactions may contribute to the development of type 2 diabetes but research evidence to date is inconclusive. We aimed to increase our understanding of the aetiology of type 2 diabetes by investigating potential interactions between genes and macronutrient intake and their association with the incidence of type 2 diabetes. METHODS: We investigated the influence of interactions between genetic risk scores (GRSs) for type 2 diabetes, insulin resistance and BMI and macronutrient intake on the development of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a prospective case-cohort study across eight European countries (N = 21,900 with 9742 incident type 2 diabetes cases). Macronutrient intake was estimated from diets reported in questionnaires, including proportion of energy derived from total carbohydrate, protein, fat, plant and animal protein, saturated, monounsaturated and polyunsaturated fat and dietary fibre. Using multivariable-adjusted Cox regression, we estimated country-specific interaction results on the multiplicative scale, using random-effects meta-analysis. Secondary analysis used isocaloric macronutrient substitution. RESULTS: No interactions were identified between any of the three GRSs and any macronutrient intake, with low-to-moderate heterogeneity between countries (I2range 0-51.6%). Results were similar using isocaloric macronutrient substitution analyses and when weighted and unweighted GRSs and individual SNPs were examined. CONCLUSIONS/INTERPRETATION: Genetic susceptibility to type 2 diabetes, insulin resistance and BMI did not modify the association between macronutrient intake and incident type 2 diabetes. This suggests that macronutrient intake recommendations to prevent type 2 diabetes do not need to account for differences in genetic predisposition to these three metabolic conditions.
AU  - Li,SX
AU  - Imamura,F
AU  - Schulze,MB
AU  - Zheng,J
AU  - Ye,Z
AU  - Agudo,A
AU  - Ardanaz,E
AU  - Aune,D
AU  - Boeing,H
AU  - Dorronsoro,M
AU  - Dow,C
AU  - Fagherazzi,G
AU  - Grioni,S
AU  - Gunter,MJ
AU  - Huerta,JM
AU  - Ibsen,DB
AU  - Jakobsen,MU
AU  - Kaaks,R
AU  - Key,TJ
AU  - Khaw,K-T
AU  - Kyrø,C
AU  - Mancini,FR
AU  - Molina-Portillo,E
AU  - Murphy,N
AU  - Nilsson,PM
AU  - Onland-Moret,NC
AU  - Palli,D
AU  - Panico,S
AU  - Poveda,A
AU  - Quirós,JR
AU  - Ricceri,F
AU  - Sluijs,I
AU  - Spijkerman,AMW
AU  - Tjonneland,A
AU  - Tumino,R
AU  - Winkvist,A
AU  - Langenberg,C
AU  - Sharp,SJ
AU  - Riboli,E
AU  - Scott,RA
AU  - Forouhi,NG
AU  - Wareham,NJ
DO  - 10.1007/s00125-018-4586-2
EP  - 1332
PY  - 2018///
SN  - 0012-186X
SP  - 1325
TI  - Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries
T2  - Diabetologia
UR  - http://dx.doi.org/10.1007/s00125-018-4586-2
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29549418
UR  - http://hdl.handle.net/10044/1/58465
VL  - 61
ER  -

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