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@article{Agudo:2018:ajcn/nqy002,
author = {Agudo, A and Cayssials, V and Bonet, C and Tjonneland, A and Overvad, K and Boutron-Ruault, M-C and Affret, A and Fagherazzi, G and Katzke, V and Schubel, R and Trichopoulou, A and Karakatsani, A and La, Vecchia C and Palli, D and Grioni, S and Tumino, R and Ricceri, F and Panico, S and Bueno-de-Mesquita, B and Peeters, PH and Weiderpass, E and Skeie, G and Nost, TH and Lasheras, C and Rodriguez-Barranco, M and Amiano, P and Chirlaque, M-D and Ardanaz, E and Ohlsson, B and Dias, JA and Nilsson, LM and Myte, R and Khaw, K-T and Perez-Cornago, A and Gunter, M and Huybrechts, I and Cross, AJ and Tsilidis, K and Riboli, E and Jakszyn, P},
doi = {ajcn/nqy002},
journal = {AMERICAN JOURNAL OF CLINICAL NUTRITION},
pages = {607--616},
title = {Inflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study},
url = {http://dx.doi.org/10.1093/ajcn/nqy002},
volume = {107},
year = {2018}
}

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TY  - JOUR
AB  - BackgroundChronic inflammation plays a critical role in the pathogenesis of the 2 major types of gastric cancer. Several foods, nutrients, and nonnutrient food components seem to be involved in the regulation of chronic inflammation.ObjectiveWe assessed the association between the inflammatory potential of the diet and the risk of gastric carcinoma, overall and for the 2 major subsites: cardia cancers and noncardia cancers.DesignA total of 476,160 subjects (30% men, 70% women) from the European Investigation into Cancer and Nutrition (EPIC) study were followed for 14 y, during which 913 incident cases of gastric carcinoma were identified, including 236 located in the cardia, 341 in the distal part of the stomach (noncardia), and 336 with overlapping or unknown tumor site. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated with the use of 28 dietary components and their corresponding inflammatory scores. The association between the ISD and gastric cancer risk was estimated by HRs and 95% CIs calculated by multivariate Cox regression models adjusted for confounders.ResultsThe inflammatory potential of the diet was associated with an increased risk of gastric cancer. The HR (95% CI) for each increase in 1 SD of the ISD were 1.25 (1.12, 1.39) for all gastric cancers, 1.30 (1.06, 1.59) for cardia cancers, and 1.07 (0.89, 1.28) for noncardia cancers. The corresponding values for the highest compared with the lowest quartiles of the ISD were 1.66 (1.26, 2.20), 1.94 (1.14, 3.30), and 1.07 (0.70, 1.70), respectively.ConclusionsOur results suggest that low-grade chronic inflammation induced by the diet may be associated with gastric cancer risk. This pattern seems to be more consistent for gastric carcinomas located in the cardia than for those located in the distal stomach.
AU  - Agudo,A
AU  - Cayssials,V
AU  - Bonet,C
AU  - Tjonneland,A
AU  - Overvad,K
AU  - Boutron-Ruault,M-C
AU  - Affret,A
AU  - Fagherazzi,G
AU  - Katzke,V
AU  - Schubel,R
AU  - Trichopoulou,A
AU  - Karakatsani,A
AU  - La,Vecchia C
AU  - Palli,D
AU  - Grioni,S
AU  - Tumino,R
AU  - Ricceri,F
AU  - Panico,S
AU  - Bueno-de-Mesquita,B
AU  - Peeters,PH
AU  - Weiderpass,E
AU  - Skeie,G
AU  - Nost,TH
AU  - Lasheras,C
AU  - Rodriguez-Barranco,M
AU  - Amiano,P
AU  - Chirlaque,M-D
AU  - Ardanaz,E
AU  - Ohlsson,B
AU  - Dias,JA
AU  - Nilsson,LM
AU  - Myte,R
AU  - Khaw,K-T
AU  - Perez-Cornago,A
AU  - Gunter,M
AU  - Huybrechts,I
AU  - Cross,AJ
AU  - Tsilidis,K
AU  - Riboli,E
AU  - Jakszyn,P
DO  - ajcn/nqy002
EP  - 616
PY  - 2018///
SN  - 0002-9165
SP  - 607
TI  - Inflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
T2  - AMERICAN JOURNAL OF CLINICAL NUTRITION
UR  - http://dx.doi.org/10.1093/ajcn/nqy002
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000429449300014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/59115
VL  - 107
ER  -

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