Tate Group Overview
Our research lies at the interface between organic chemistry, the life sciences and medicine, in the fields of chemical biology and chemical proteomics. The unifying theme of our work is the design and application of chemical approaches to understand and manipulate living systems, with an emphasis on processes important to disease. Related to this theme, our group also undertakes research in medicinal chemistry and chemical synthesis/modification of proteins and peptides.
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About Prof. Ed Tate
Ed works in the Chemical Biology Section of the Department of Chemistry, and holds a Satellite Group Leader appointment at the Francis Crick Institute. He is a Fellow of both the Royal Society of Chemistry (FRSC) and the Royal Society of Biology (FRSB), and has been the recipient of three prestigious research fellowships, and research grants from the UK research councils, charity foundations, the EU and the pharmaceutical and biotech industries. He sits on the editorial advisory boards of Cell Chemical Biology, Molecular BioSystems, the Journal of Chemical Biology and the Biochemical Journal, sits on the steering committee of the EU COST action ChemProbes, the committee of the RSC Bioorganic Group, and the ICR/Imperial Cancer Research Centre of Excellence board. He was awarded the 2012 Wain Medal Lecture and Prize and the 2013 RSC/MedImmune Protein and Peptide Science Award in recognition of his research in chemical biology, and was elected FRSC in 2013, and FRSB in 2014. He also recevied the 2013 President and Rector's Award for Excellence in Research Supervision, the 2014 Norman Heatley Award in Chemical Biology, and a 2015 CRUK Programme Foundation Award.
Following a B.Sc. degree in chemistry at the University of Durham, Ed undertook his Ph.D. in organic chemistry and methodology at the University of Cambridge under the guidance of Prof. Steve Ley. He then w orked for two years with Prof. Sam Zard at Ecole Polytechnique (Paris) on an 1851 Research Fellowship, on radical chemistry and natural product total synthesis. The award of a Howard Trust Research Fellowship enabled him to study molecular microbiology and the role of DNA secondary st ructure in transcriptional activation with Dr. Annie Kolb at the Pasteur Institute (Paris), and following this period of training in biological research he moved to Imperial College London to work on protein chemistry and chemical biology with Prof. Robin Leatherbarrow. In 2006 he was awarded a BBSRC David Phillips Research Fellowship; in 2010 he was appointed Senior Lecturer, promoted to Reader in Chemical Biology in 2012, and to Professor of Chemical Biology in 2014.
et al., 2016, Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells, ACS Chemical Biology, Vol:11, ISSN:1554-8929, Pages:3268-3272
et al., 2016, Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei, Acs Infectious Diseases, Vol:2, ISSN:2373-8227, Pages:427-441
et al., 2016, Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach, Molecular & Cellular Proteomics, Vol:15, ISSN:1535-9476, Pages:715-725
et al., 2015, Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation, Chemistry & Biology, Vol:22, ISSN:1074-5521, Pages:1562-1573
et al., 2015, Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development, Angewandte Chemie - International Edition, Vol:54, ISSN:1433-7851, Pages:5948-5951
et al., 2015, Targeting a Dynamic Protein-Protein Interaction: Fragment Screening against the Malaria Myosin A Motor Complex, Chemmedchem, Vol:10, ISSN:1860-7179, Pages:134-143
et al., 2014, Structure-Based Design of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors, Journal of Medicinal Chemistry, Vol:57, ISSN:0022-2623, Pages:8664-8670
et al., 2014, Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein-Helix Interaction, ACS Chemical Biology, Vol:9, ISSN:1554-8929, Pages:2204-2209
et al., 2014, New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish, Chemical Science, Vol:5, ISSN:2041-6520, Pages:4249-4259
et al., 2014, Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation, Cell Host & Microbe, Vol:16, ISSN:1931-3128, Pages:128-140
et al., 2014, Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP), Journal of Medicinal Chemistry, Vol:57, ISSN:0022-2623, Pages:2773-2788
et al., 2014, Global profiling of co- and post-translationally N-myristoylated proteomes in human cells, Nature Communications, Vol:5, ISSN:2041-1723
et al., 2014, Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach, Nature Chemistry, Vol:6, ISSN:1755-4330, Pages:112-121
et al., 2016, Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells, ACS Chemical Biology, Vol:11, ISSN:1554-8929, Pages:3256-3262