Tate Group Overview
Our research lies at the interface between organic chemistry, the life sciences and medicine, in the fields of chemical biology and chemical proteomics. The unifying theme of our work is the design and application of chemical approaches to understand and manipulate living systems, with an emphasis on processes important to disease. Related to this theme, our group also undertakes research in medicinal chemistry and chemical synthesis/modification of proteins and peptides.
NEW positions available
Postdoctoral Researcher in Chemical Biology
We are seeking an outstanding chemical biologist to join our group to work on a BBSRC-funded project in collaboration with Prof Gary Frost and colleagues in the Department of Medicine, for a period of 2 years. The project focuses on understanding the role of short chain fatty acid GPCRs in regulation of appetite-related hormones, with significant potential impact on the growing worldwide obesity epidemic. The research will involve design, synthesis and application of small molecule probes for these GPCRs, and is backed by a robust combination of proteomic, biochemical and cellular assays. Candidates should hold a PhD in chemical biology, preferably with experience developing chemical probes for membrane proteins. This position will be advertised shortly, and will start in September 2016; in the meantime, informal enquiries may be made to Prof Ed Tate (please send your CV by email).
Postdoctoral Researcher/Lab Manager in Medicinal Chemistry
We are seeking a highly motivated scientist with a background in organic synthesis and medicinal chemistry/chemical biology, to take a lead in developing and supporting medicinal chemistry research in our lab, and more widely in the Department. The position will involve significant responsibility and creative input into medicinal chemistry projects, particularly through supervision of students on Imperial's MRes in Drug Discovery and Development. The role will also involve management of our synthetic chemistry labs, and the opportunity to develop new initiatives in medicinal chemistry (e.g. screening capabilities). The position will be available for one year in the first instance, with the intention that the post will be extended to 2 years or beyond subject to performance. Candidates should hold a PhD in organic/medicinal chemistry, preferably with experience in research student supervision and lab management. This position will be advertised in due course, and will start in October 2016; in the meantime, informal enquiries may be made to Prof Ed Tate (please send your CV via email).
Other Postdoctoral Opportunities
We welcome informal enquiries from potential postdoctoral fellows with outstanding research track records who are prepared to apply for independent research funding, for example from the European Union, HFSP, etc. Full assistance will be given in preparing a competitive research proposal; we have an exceptional track record in accelerating the careers of outstanding postdoctoral researchers, with six Marie Curie fellows in our lab in the past four years.
Any students interested in pursuing postgraduate research in our group should contact me directly; all prospective applicants should have or expect to obtain a 1st class honours degree (or equivalent) in chemistry, biochemistry, or a closely related discipline; non-UK students must be able to obtain independent funding for their studies, e.g. via a government bursary.
Group News - congratulations to...
Manue and Julia, as their paper "N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells" goes online at ACS Chemial Biology.
Many thanks to Monica, Julia, Charlotte and Mostafa, who presented Cancer Research UK-funded research in our lab at the 2016 Imperial College Festival, running 10 fully-booked lab tours. Visitors loaded and ran their own protein gels, imaged with multi-colour fluorescence, and observed cancer cells under the microscope, whilst learning about our work identifying and validating new drug targets in cancer.
Tom won a prize at the 2016 RSC Chemical Biology Symposium in London for his poster on novel assays for protein acyltransferases, alongside a great poster from Julia on probes for prenylation.
Roman won a poster prize at the recent NextGenAgriChem symposium at Bayer in Frankfurt.
Rhiannon who has won a Pathways to Impact award to continue her research on delivery vehicles for the blood-brain barrier.
Louis who passed his PhD viva on his thesis on site-specific dual fluorescent labelling and single molecule dynamics of the tyrosine kinase FGFR. Congratulations Dr Perdios!
Ernie and Goska as their paper "The Rab-binding profiles of bacterial virulence factors during infection" with the Frankel lab goes online at J. Biol. Chem. (Open Access).
Goska and Remi as their paper "Global profiling of HYPE mediated AMPylation through a chemical proteomic approach" goes online at Molecular & Cellular Proteomics (Open Access).
Tom Charlton, as his paper "Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation" goes online at Chemistry & Biology (Open Access).
Remi, as his paper "Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics" goes online at Chemistry & Biology (Open Access).
Andy who passed his PhD viva on his thesis "N-Myristoyltransferase as a drug target: A (Chemical) Space Odyessy". Congratulations Dr Bell! Andy is continuing to develop NMT inhibitors in the Tate group.
Jessica, Wenye, Gee, Julia and Yunyun completed the Race for Life in Hyde Park, raising money for Cancer Research UK.
Scott won 1st Prize at the 2015 MaxQuant Summer School at the Max Planck Institute (Martinsreid, Germany) for his poster on targeting the KLK Activome in drug-resistant prostate cancer using chemical proteomics and systems biology.
Jenny and Louis won the 1st and 2nd prizes for their talks at the Department's annual Postgraduate Reserach Symposium, whilst Yunyun won a poster prize - congratulations!
Feny won a prize for her talk given at the 2015 joint CDT Chemical Biology Conference.
Tom has passed his PhD viva on his thesis "Chemical Proteomic Profiling to Investigate Lipoprotein Biogenesis in Clostridium difficile". Congratulations Dr Charlton! Tom is now a postdoc in the Kessler lab at the University of Oxford.
The group attended the 2015 Chemical Proteomics Symposium in Oxford, sponsored by the ChemProbes COST network, with Ed, Markus and Remi giving talks and Jenny, Feny, Scott, Sharlin and Kate presenting posters.
Goska, Remi and Paulina as their paper 'Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development' is featured as a Hot Paper in Angewandte Chemie International Edition.
Megan, Lisa and Remi, as their paper 'Global Analysis of Protein N-Myristoylation and Exploration of N-Myristoyltransferase as a Drug Target in the Neglected Human Pathogen Leishmania donovani' is featured on the cover of the March issue of Chemistry & Biology (Open Access) and on the College Website.
About Prof. Ed Tate
Ed works in the Chemical Biology Section of the Department of Chemistry. He is a Fellow of both the Royal Society of Chemistry (FRSC) and the Royal Society of Biology (FRSB), and has been the recipient of three prestigious research fellowships, and research grants from the UK research councils, charity foundations, the EU and the pharmaceutical and biotech industries. He sits on the editorial advisory board of the Journal of Chemical Biology and the Biochemical Journal, chairs the Chemistry Department's Early Career Development Committee, sits on the steering committee of the EU COST action ChemProbes, and the committee of the RSC Bioorganic Group. He was awarded the 2012 Wain Medal Lecture and Prize and the 2013 RSC/MedImmune Protein and Peptide Science Award in recognition of his research in chemical biology, and was elected FRSC in 2013, and FRSB in 2014. He also recevied the 2013 President and Rector's Award for Excellence in Research Supervision, and the 2014 Norman Heatley Award in Chemical Biology.
Following a B.Sc. degree in chemistry at the University of Durham, Ed undertook his Ph.D. in organic chemistry and methodology at the University of Cambridge under the guidance of Prof. Steve Ley. He then w orked for two years with Prof. Sam Zard at Ecole Polytechnique (Paris) on an 1851 Research Fellowship, on radical chemistry and natural product total synthesis. The award of a Howard Trust Research Fellowship enabled him to study molecular microbiology and the role of DNA secondary st ructure in transcriptional activation with Dr. Annie Kolb at the Pasteur Institute (Paris), and following this period of training in biological research he moved to Imperial College London to work on protein chemistry and chemical biology with Prof. Robin Leatherbarrow. In 2006 he was awarded a BBSRC David Phillips Research Fellowship; in 2010 he was appointed Senior Lecturer, promoted to Reader in Chemical Biology in 2012, and to Professor of Chemical Biology in 2014.
et al., 2016, Global profiling and inhibition of protein lipidation in vector andhost stages of the sleeping sickness parasite Trypanosoma brucei, Acs Infectious Diseases, ISSN:2373-8227
et al., 2016, Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach, Molecular & Cellular Proteomics, Vol:15, ISSN:1535-9476, Pages:715-725
et al., 2015, Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation, Chemistry & Biology, Vol:22, ISSN:1074-5521, Pages:1562-1573
et al., 2015, Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development, Angewandte Chemie - International Edition, Vol:54, ISSN:1433-7851, Pages:5948-5951
et al., 2014, New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish, Chemical Science, Vol:5, ISSN:2041-6520, Pages:4249-4259
et al., 2015, Targeting a Dynamic Protein-Protein Interaction: Fragment Screening against the Malaria Myosin A Motor Complex, Chemmedchem, Vol:10, ISSN:1860-7179, Pages:134-143
et al., 2014, Global profiling of co- and post-translationally N-myristoylated proteomes in human cells, Nature Communications, Vol:5, ISSN:2041-1723
et al., 2014, Structure-Based Design of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors, Journal of Medicinal Chemistry, Vol:57, ISSN:0022-2623, Pages:8664-8670
et al., 2014, Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein-Helix Interaction, ACS Chemical Biology, Vol:9, ISSN:1554-8929, Pages:2204-2209
et al., 2014, Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation, Cell Host & Microbe, Vol:16, ISSN:1931-3128, Pages:128-140
et al., 2014, Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP), Journal of Medicinal Chemistry, Vol:57, ISSN:0022-2623, Pages:2773-2788
et al., 2014, Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach, Nature Chemistry, Vol:6, ISSN:1755-4330, Pages:112-121