Imperial College London

Prof Ed Tate

Faculty of Natural SciencesDepartment of Chemistry

Professor of Chemical Biology
 
 
 
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Contact

 

+44 (0)20 7594 3752e.tate Website CV

 
 
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Assistant

 

Ms Agnes Lee +44 (0)20 7594 9852

 
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Location

 

639ChemistrySouth Kensington Campus

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Summary

 

Summary

Tate Group Overview

Our research lies at the interface between organic chemistry, the life sciences and medicine, in the fields of chemical biology and chemical proteomics. The unifying theme of our work is the design and application of chemical approaches to understand and manipulate living systems, with an emphasis on processes important to disease. Related to this theme, our group also undertakes research in medicinal chemistry and chemical synthesis/modification of proteins and peptides.

New: Three PhD studentships available

We are recruiting for three PhD studentships, open to EU and Swiss citizens (NB: non EU citizens are not eligible), holding (or expecting to hold) a top class Masters level qualification in a molecular science subject (chemistry, medicinal chemistry, chemical biology, natural sciences, etc.). One studentship is available ASAP, two start in October 2018. Please see below for further details, and email your CV and cover letter to Prof Tate to start the application process.

3-year PhD (available to start immediately): Controlling appetite through G protein coupled receptors: new chemical probes to understand the roles of signalling in health and disease. You will join a multidisciplinary team of experienced postdoctoral and postgraduate researchers funded by EPSRC, BBSRC and Nestle, to develop novel approaches to target GPCRs in the human gut involved in obesity and diabetes. Please click here for further information.

4-year PhD (starting October 2018, deadline 13th November 2017): A chemical biology approach to target protein lipidation in development and neurodegenerative disease. You will join the Tate and Vincent labs at the Francis Crick Institute to design and implement a rich array of chemical tools to address the pressing challenge of understanding the roles of reversible lipidation in protein secretion and signalling, and enable novel insights into both disease and normal development. These tools will range from activity-based probes for lipid processing enzymes, to probes which can capture lipidated proteins and their interacting partners in living system, and will be implemented in cultured cells and animal models. This studentship attracts an enhanced stipend; please click here for further information, and to apply online.

4-year PhD (starting October 2018, deadline 20th November 2017): Targeting a critical vulnerability of metastatic cancer through chemical biology. You will be at the centre of a multidisciplinary collaboration between Imperial, The Institute of Cancer Research and the Francis Crick Institute, in which you will design, synthesise and test optimised chemical probes to reveal the role of a lipid transferase critical for metastatic cancer. Your work will make a key contribution to validation of this protein as a potential drug target, including developing new, broadly applicable chemical biology and chemical proteomics approaches to identify and explore substrates, and studies towards the discovery of the first inhibitors for this class of emerging targets. This studentship attracts an enhanced stipend; further details will be posted shortly on Findaphd.com, but in the meantime you may email your CV and cover letter to Prof Tate to express an interest in this opportunity.

Please also see the main Tate Group Website for further information on:

About Prof. Ed Tate

Ed works in the Chemical Biology Section of the  Department of Chemistry, and holds a Satellite Group Leader appointment at the Francis Crick Institute. He is a Fellow of both the Royal Society of Chemistry (FRSC) and the Royal Society of Biology (FRSB), and has been the recipient of three prestigious research fellowships, and research grants from the UK research councils, charity foundations, the EU and the pharmaceutical and biotech industries. He sits on the editorial advisory boards of Cell Chemical Biology, Molecular BioSystems, the Journal of Chemical Biology and the Biochemical Journal, sits on the steering committee of the EU COST action ChemProbes, the committee of the RSC Bioorganic Group, and the ICR/Imperial Cancer Research Centre of Excellence board. He was awarded the 2012 Wain Medal Lecture and Prize and the 2013 RSC/MedImmune Protein and Peptide Science Award in recognition of his research in chemical biology, and was elected FRSC in 2013, and FRSB in 2014. He also recevied the 2013 President and Rector's Award for Excellence in Research Supervision, the 2014 Norman Heatley Award in Chemical Biology, and a 2015 CRUK Programme Foundation Award.

Following a B.Sc. degree in chemistry at the University of Durham, Ed undertook his Ph.D. in organic chemistry and methodology at the University of Cambridge under the guidance of  Prof. Steve Ley. He then w orked for two years with Prof. Sam Zard at Ecole Polytechnique (Paris) on an 1851 Research Fellowship, on radical chemistry and natural product total synthesis. The award of a Howard Trust Research Fellowship  enabled him to study molecular microbiology and the role of DNA secondary st ructure in transcriptional activation with Dr. Annie Kolb at the Pasteur Institute (Paris), and following this period of training in biological research he moved to Imperial College London to work on protein chemistry and chemical biology with Prof. Robin Leatherbarrow. In 2006 he was awarded a BBSRC David Phillips Research Fellowship; in 2010 he was appointed Senior Lecturer, promoted to Reader in Chemical Biology in 2012, and to Professor of Chemical Biology in 2014.

Selected Publications

Journal Articles

Ward JA, McLellan L, Stockley M, et al., 2016, Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells, ACS Chemical Biology, Vol:11, ISSN:1554-8929, Pages:3268-3272

Rodgers UR, Lanyon-Hogg T, Masumoto N, et al., 2016, Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells, ACS Chemical Biology, Vol:11, ISSN:1554-8929, Pages:3256-3262

Wright MH, Paape D, Price HP, et al., 2016, Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei, Acs Infectious Diseases, Vol:2, ISSN:2373-8227, Pages:427-441

Broncel M, Serwa RA, Bunney TD, et al., 2016, Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach, Molecular & Cellular Proteomics, Vol:15, ISSN:1535-9476, Pages:715-725

Charlton TM, Kovacs-Simon A, Michell SL, et al., 2015, Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation, Chemistry & Biology, Vol:22, ISSN:1074-5521, Pages:1562-1573

Broncel M, Serwa RA, Ciepla P, et al., 2015, Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development, Angewandte Chemie - International Edition, Vol:54, ISSN:1433-7851, Pages:5948-5951

Ciepla P, Konitsiotis AD, Serwa RA, et al., 2014, New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish, Chemical Science, Vol:5, ISSN:2041-6520, Pages:4249-4259

Douse CH, Vrielink N, Zhang W, et al., 2015, Targeting a Dynamic Protein-Protein Interaction: Fragment Screening against the Malaria Myosin A Motor Complex, Chemmedchem, Vol:10, ISSN:1860-7179, Pages:134-143

Thinon E, Serwa RA, Broncel M, et al., 2014, Global profiling of co- and post-translationally N-myristoylated proteomes in human cells, Nature Communications, Vol:5, ISSN:2041-1723

Hutton JA, Goncalves V, Brannigan JA, et al., 2014, Structure-Based Design of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors, Journal of Medicinal Chemistry, Vol:57, ISSN:0022-2623, Pages:8664-8670

Douse CH, Maas SJ, Thomas JC, et al., 2014, Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein-Helix Interaction, ACS Chemical Biology, Vol:9, ISSN:1554-8929, Pages:2204-2209

Guttery DS, Poulin B, Ramaprasad A, et al., 2014, Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation, Cell Host & Microbe, Vol:16, ISSN:1931-3128, Pages:128-140

Rackham MD, Brannigan JA, Rangachari K, et al., 2014, Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP), Journal of Medicinal Chemistry, Vol:57, ISSN:0022-2623, Pages:2773-2788

Wright MH, Clough B, Rackham MD, et al., 2014, Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach, Nature Chemistry, Vol:6, ISSN:1755-4330, Pages:112-121

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