Summary
Tate Group Overview
Our research lies at the interface between organic chemistry, the life sciences and medicine, in the fields of chemical biology and chemical proteomics. The unifying theme of our work is the design and application of chemical approaches to understand and manipulate living systems, with an emphasis on processes important to disease. Related to this theme, our group also undertakes research in medicinal chemistry and chemical synthesis/modification of proteins and peptides.
Please also see the main Tate Group Website for further information on:
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About Prof. Ed Tate
Ed works in the Chemical Biology Section of the Department of Chemistry, and holds a Satellite Group Leader appointment at the Francis Crick Institute. He is a Fellow of both the Royal Society of Chemistry (FRSC) and the Royal Society of Biology (FRSB), and has been the recipient of three prestigious research fellowships, and research grants from the UK research councils, charity foundations, the EU and the pharmaceutical and biotech industries. He sits on the editorial advisory boards of Cell Chemical Biology, Molecular BioSystems, and the Biochemical Journal, the committee of the RSC Bioorganic Group, the ICR/Imperial Cancer Research Centre of Excellence board, and is the Director of the Imperial Centre for Drug Discovery Science. He was awarded the 2012 Wain Medal Lecture and Prize and the 2013 RSC/MedImmune Protein and Peptide Science Award in recognition of his research in chemical biology, and was elected FRSC in 2013, and FRSB in 2014. He also recevied the 2013 President and Rector's Award for Excellence in Research Supervision, the 2014 Norman Heatley Award in Chemical Biology, a 2015 CRUK Programme Foundation Award, the 2019 Sir David Cooksey Translation Prize, and the 2020 RSC Corday-Morgan Prize. In 2023, Prof. Tate was appointed to the GSK Chair in Chemical Biology.
Following a B.Sc. degree in chemistry at the University of Durham, Ed undertook his Ph.D. in organic chemistry and methodology at the University of Cambridge under the guidance of Prof. Steve Ley. He then w orked for two years with Prof. Sam Zard at Ecole Polytechnique (Paris) on an 1851 Research Fellowship, on radical chemistry and natural product total synthesis. The award of a Howard Trust Research Fellowship enabled him to study molecular microbiology and the role of DNA secondary st ructure in transcriptional activation with Dr. Annie Kolb at the Pasteur Institute (Paris), and following this period of training in biological research he moved to Imperial College London to work on protein chemistry and chemical biology with Prof. Robin Leatherbarrow. In 2006 he was awarded a BBSRC David Phillips Research Fellowship; in 2010 he was appointed Senior Lecturer, promoted to Reader in Chemical Biology in 2012, and to Professor of Chemical Biology in 2014.
Ed is also co-founder of Myricx Pharma, which is a spin-out company based on NMT work started within the research group. Here, Ed is also the chairman of the scientific advisory board. In addition to this, he was also appointed to the scientific advisory board of Samsara Therapeutics Inc. in January 2022.
Selected Publications
Journal Articles
Zhang L, Lovell S, De Vita E, et al., 2022, A KLK6 activity-based probe reveals a role for KLK6 activity in pancreatic cancer cell invasion, Journal of the American Chemical Society, Vol:144, ISSN:0002-7863, Pages:22493-22504
Benns HJ, Storch M, Falco JA, et al., 2022, CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery., Nat Microbiol
Priyamvada L, Kallemeijn WW, Faronato M, et al., 2022, Inhibition of vaccinia virus L1 N-myristoylation by the host N-myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entry, PLOS Pathogens, Vol:18, ISSN:1553-7366
Coupland CE, Andrei SA, Ansell TB, et al., 2021, Structure, mechanism, and inhibition of Hedgehog acyltransferase, Molecular Cell, Vol:81, ISSN:1097-2765, Pages:5025-+
Kallemeijn W, Lanyon-Hogg T, Panyain N, et al., 2021, Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualisation, identification and quantification of N-myristoylation, N- and S-acylation, Ocholesterylation, S-farnesylation and S-geranylgeranylation, Nature Protocols, Vol:16, ISSN:1750-2799, Pages:5083-5122
Lovell S, Zhang L, Kryza T, et al., 2021, A suite of activity-based probes to dissect the KLK activome in drug-resistant prostate cancer, Journal of the American Chemical Society, Vol:143, ISSN:0002-7863, Pages:8911-8924
Lanyon-Hogg T, Ritzefeld M, Zhang L, et al., 2021, Photochemical probe identification of the small-molecule binding site in a mammalian membrane-bound O-acyltransferase, Angewandte Chemie - International Edition, Vol:60, ISSN:1433-7851, Pages:13542-13547
Kryza T, Khan T, Lovell S, et al., 2021, Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1, Nature Chemical Biology, Vol:17, ISSN:1552-4450, Pages:776-783
Panyain N, Godinat A, Lanyon-Hogg T, et al., 2020, Discovery of a potent and selective covalent inhibitor and activity-based probe for the deubiquitylating enzyme UCHL1, with anti-fibrotic activity, Journal of the American Chemical Society, Vol:142, ISSN:0002-7863, Pages:12020-12026
Maneiro M, Forte N, Shchepinova MM, et al., 2020, Antibody–PROTAC conjugates enable HER2-dependent targeted protein degradation of BRD4, ACS Chemical Biology, Vol:15, ISSN:1554-8929, Pages:1306-1312
Dian C, Inmaculada P-D, Riviere F, et al., 2020, High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation, Nature Communications, Vol:11, ISSN:2041-1723, Pages:1-15
Doll S, Freitas FP, Shah R, et al., 2019, FSP1 is a glutathione-independent ferroptosis suppressor, Nature, Vol:575, ISSN:0028-0836, Pages:693-698
Kallemeijn W, Lueg G, Faronato M, et al., 2019, Validation and invalidation of chemical probes for the human N-myristoyltransferases, Cell Chemical Biology, Vol:26, ISSN:2451-9456, Pages:892-900
Storck Saha E, Morales Sanfrutos J, Serwa R, et al., 2019, Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics, Nature Chemistry, Vol:11, ISSN:1755-4330, Pages:552-561
Mousnier A, Bell AS, Swieboda DP, et al., 2018, Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus, Nature Chemistry, Vol:10, ISSN:1755-4330, Pages:599-606
Craven G, Affron D, Allen C, et al., 2018, High-throughput kinetic analysis for target-directed covalent ligand discovery, Angewandte Chemie - International Edition, Vol:57, ISSN:1433-7851, Pages:5257-5261
Broncel M, Serwa RA, Ciepla P, et al., 2015, Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development, Angewandte Chemie-international Edition, Vol:54, ISSN:1521-3773, Pages:5948-5951
Thinon E, Serwa RA, Broncel M, et al., 2014, Global profiling of co- and post-translationally N-myristoylated proteomes in human cells, Nature Communications, Vol:5, ISSN:2041-1723, Pages:1-13
Wright MH, Clough B, Rackham MD, et al., 2013, Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach, Nature Chemistry, Vol:6, ISSN:1755-4349, Pages:112-121