Imperial College London
Portrait Picture

Prof Ed Tate

Faculty of Natural Sciences, Department of Chemistry

GSK Chair in Chemical Biology
 
 
 
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Contact

 

+44 (0)20 7594 3752e.tate Website CV

 
 
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Assistant

 

Ms Agnes Lee +44 (0)20 7594 9852

 
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Location

 

301BMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ritzefeld:2017:10.1017/S0031182017000282,
author = {Ritzefeld, M and Wright, MH and Tate, EW},
doi = {10.1017/S0031182017000282},
journal = {Parasitology},
pages = {157--174},
title = {New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness},
url = {http://dx.doi.org/10.1017/S0031182017000282},
volume = {145},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Infections by protozoan parasites, such as Plasmodium falciparum or Leishmania donovani, have a significant health, social and economic impact and threaten billions of people living in tropical and sub-tropical regions of developing countries worldwide. The increasing range of parasite strains resistant to frontline therapeutics makes the identification of novel drug targets and the development of corresponding inhibitors vital. Post-translational modifications (PTMs) are important modulators of biology and inhibition of protein lipidation has emerged as a promising therapeutic strategy for treatment of parasitic diseases. In this review we summarize the latest insights into protein lipidation in protozoan parasites. We discuss how recent chemical proteomic approaches have delivered the first global overviews of protein lipidation in these organisms, contributing to our understanding of the role of this PTM in critical metabolic and cellular functions. Additionally, we highlight the development of new small molecule inhibitors to target parasite acyl transferases.
AU  - Ritzefeld,M
AU  - Wright,MH
AU  - Tate,EW
DO  - 10.1017/S0031182017000282
EP  - 174
PY  - 2017///
SN  - 1469-8161
SP  - 157
TI  - New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness
T2  - Parasitology
UR  - http://dx.doi.org/10.1017/S0031182017000282
UR  - http://hdl.handle.net/10044/1/44421
VL  - 145
ER  -
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