Dr Evangelos Triantafyllou is an Imperial College Research Fellow and member of the Liver Immunology Group (Dep. of Metabolism, Digestion & Reproduction). Evangelos received his PhD in Immunology (King’s College London), studying the mechanisms of immune-mediated injury in acute liver failure, under the supervision of Dr Harry Antoniades. He undertook part of his doctoral work at the Centre for Liver Research in collaboration with Dr Chris Weston and Prof David Adams (University of Birmingham). Evangelos went on to perform post-doctoral research at Imperial College receiving funding support from Rosetrees Trust and awarded with an Imperial College Research Fellowship (ICRF) sponsored by Prof Mark Thursz.
Evangelos’ research focuses on the role of monocytes and macrophages in the resolution of inflammation and subsequent immunosuppression in acute and chronic liver injury. He studies the cellular and molecular mechanisms by which monocytes/macrophages contribute to the pathophysiology of acute and acute-on-chronic liver failure (ALF/ACLF): how they initiate and propagate liver inflammation? how they drive hepatic and systemic immunosuppression? what immune-based therapeutic strategies can be developed to target them? Other research interests include the pathogenesis of immune checkpoint inhibitor-induced hepatitis and role of macrophages in hepatocellular carcinoma (HCC) as a therapeutic target.
QUALIFICATIONS & history:
2018-22: Imperial College Research Fellow (Imperial College)
2017-18: Research Associate (Imperial College)
2013-17: PhD, Immunology (King's College London)
2013-17: Research Assistant (King's College London)
2013-14: Visiting Research Fellow (University of Birmingham)
2011-12: MSc, Developmental Biology (University of Bath)
2006-11: BSc, Biology (University of Athens)
et al., 2018, The role of monocytes and macrophages in acute and acute-on-chronic liver failure, Frontiers in Immunology, Vol:9, ISSN:1664-3224
et al., 2017, CD14+CD15-HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure, Gut, Vol:67, ISSN:1468-3288, Pages:1155-1167
et al., 2017, MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure, Gut, Vol:67, ISSN:1468-3288, Pages:333-347
et al., 2015, High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial, Journal of Hepatology, Vol:64, ISSN:1600-0641, Pages:69-78
et al., 2015, Patients With Acute-on-Chronic Liver Failure Have Increased Numbers of Regulatory Immune Cells Expressing the Receptor Tyrosine Kinase MERTK, Gastroenterology, Vol:148, ISSN:0016-5085, Pages:603-+