Imperial College London


Faculty of MedicineSchool of Public Health

Senior Lecturer



+44 (0)20 7594 1933e.volz Website




UG10Norfolk PlaceSt Mary's Campus






BibTex format

author = {Le, Vu S and Ratmann, O and Delpech, V and Brown, AE and Gill, ON and Tostevin, A and Dunn, D and Fraser, C and Volz, EM},
doi = {10.1101/342774},
publisher = {Cold Spring Harbor Laboratory},
title = {Mixing patterns of HIV transmission among men who have sex with men in the United Kingdom},
url = {},
year = {2018}

RIS format (EndNote, RefMan)

AB - <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Near 60% of new HIV infections in the United Kingdom are estimated to occur in men who have sex with men (MSM). Patterns of mixing between different risk groups of MSM have been suggested to spread the HIV epidemics through age-disassortative partnerships and to contribute to ethnic disparities in infection rates. Understanding these mixing patterns in transmission can help to determine which groups are at a greater risk and guide prevention.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We analyzed combined epidemiologic data and viral sequences from MSM diagnosed with HIV as of mid-2015 at the national level. We applied a phylodynamic source attribution model to infer patterns of transmission between groups of patients by age, ethnicity and region.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>From pair probabilities of transmission between 19 847 MSM patients, we found that potential transmitters of HIV subtype B were on average 5 months older than recipients. We also found a moderate overall assortativity of transmission by ethnic group and a stronger assortativity by region.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Our findings suggest that there is only a modest net flow of transmissions from older to young MSM in subtype B epidemics and that young MSM, both for Black or White groups, are more likely to be infected by one another than expected in a sexual network with random mixing.</jats:p></jats:sec>
AU - Le,Vu S
AU - Ratmann,O
AU - Delpech,V
AU - Brown,AE
AU - Gill,ON
AU - Tostevin,A
AU - Dunn,D
AU - Fraser,C
AU - Volz,EM
DO - 10.1101/342774
PB - Cold Spring Harbor Laboratory
PY - 2018///
TI - Mixing patterns of HIV transmission among men who have sex with men in the United Kingdom
UR -
ER -