Imperial College London


Faculty of MedicineSchool of Public Health

Senior Lecturer



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BibTex format

author = {Dennis, AM and Volz, E and Frost, SDW and Hossain, ASMM and Poon, AFY and Rebeiro, PF and Vermund, SH and Sterling, TR and Kalish, ML},
doi = {10.1089/aid.2018.0039},
journal = {AIDS Research and Human Retroviruses},
pages = {879--888},
title = {HIV-1 transmission clustering and phylodynamics highlight the important role of young men who have sex with men},
url = {},
volume = {34},
year = {2018}

RIS format (EndNote, RefMan)

AB - More persons living with HIV reside in the Southern United States than in any other region, yet little is known about HIV molecular epidemiology in the South. We used cluster and phylodynamic analyses to evaluate HIV transmission patterns in middle Tennessee. We performed cross-sectional analyses of HIV-1 pol sequences and clinical data collected from 2001 to 2015 among persons attending the Vanderbilt Comprehensive Care Clinic. Transmission clusters were identified using maximum likelihood phylogenetics and patristic distance differences. Demographic, risk behavior, and clinical factors were assessed evaluating “active” clusters (clusters including sequences sampled 2011–2015) and associations estimated with logistic regression. Transmission risk ratios for men who have sex with men (MSM) were estimated with phylodynamic models. Among 2915 persons (96% subtype-B sequences), 963 (33%) were members of 292 clusters (distance ≤1.5%, size range 2–39). Most clusters (62%, n = 690 persons) were active, either being newly identified (n = 80) or showing expansion on existing clusters (n = 101). Correlates of active clustering among persons with sequences collected during 2011–2015 included MSM risk and ≤30 years of age. Active clusters were significantly more concentrated in MSM and younger persons than historical clusters. Young MSM (YMSM) (≤26.4 years) had high estimated transmission risk [risk ratio = 4.04 (2.85–5.65) relative to older MSM] and were much more likely to transmit to YMSM. In this Tennessee cohort, transmission clusters over time were more concentrated by MSM and younger age, with high transmission risk among and between YMSM, highlighting the importance of interventions among this group. Detecting active clusters could help direct interventions to disrupt ongoing transmission chains.
AU - Dennis,AM
AU - Volz,E
AU - Frost,SDW
AU - Hossain,ASMM
AU - Poon,AFY
AU - Rebeiro,PF
AU - Vermund,SH
AU - Sterling,TR
AU - Kalish,ML
DO - 10.1089/aid.2018.0039
EP - 888
PY - 2018///
SN - 0889-2229
SP - 879
TI - HIV-1 transmission clustering and phylodynamics highlight the important role of young men who have sex with men
T2 - AIDS Research and Human Retroviruses
UR -
UR -
UR -
VL - 34
ER -