I am the Waters Senior Lecturer in Molecular Spectroscopy in the Department of Surgery and Cancer. I joined Imperial College in 2006 after working as a postdoctoral researcher at the Scripps Research Institute in La Jolla, CA. At Imperial College, I was initially a postdoctoral researcher for the Consortium for Metabonomic Toxicology (COMET) group.
My research focuses primarily on the development and application of novel mass spectrometry (MS) based techniques for metabolic phenotyping and on the fusion of mass spectrometric methods with chemometric analysis, which is currently a significant bottleneck in the analysis pipeline. Broadly, my research at Imperial College has involved the development, optimisation and application of UPLC-MS methodologies for the analysis of biological samples, largely in the context of metabolic phenotyping: serum, urine, tissue, amniotic fluid, and microdialysates. These developmental advances have resulted in shorter analysis times – and therefore higher sample throughput – key for large scale metabolic phenotyping studies. Peak detection and analytical reproducibility have been enhanced, improving metabolome coverage and the potential for biomarker identification and quantification.
I am applying these methods to biomedical research areas including toxicology, cardiovascular disease, neonatal disease and development, maternal exposures and effects on early childhood, and neurological diseases.
et al., 2017, System-based proteomic and metabonomic analysis of the Df(16)A(+/-) mouse identifies potential miR-185 targets and molecular pathway alterations, Molecular Psychiatry, Vol:22, ISSN:1359-4184, Pages:384-395
et al., 2016, Prolonged Mechanical Circumferential Stretch Induces Metabolic Changes in Rat Inferior Vena Cava, European Journal of Vascular and Endovascular Surgery, Vol:52, ISSN:1078-5884, Pages:544-552
et al., 2016, A randomised trial of a medium-chain TAG diet as treatment for dogs with idiopathic epilepsy (vol 114, pg 1438, 2015), British Journal of Nutrition, Vol:115, ISSN:0007-1145, Pages:1696-1696
et al., 2016, Multivariate metabotyping of plasma predicts survival in patients with decompensated cirrhosis, Journal of Hepatology, Vol:64, ISSN:0168-8278, Pages:1058-1067
et al., 2016, Global metabolic changes induced by plant-derived pyrrolizidine alkaloids following a human poisoning outbreak and in a mouse model, Toxicology Research, Vol:5, ISSN:2045-452X, Pages:1594-1603