Imperial College London
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DrEdwardMullins

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Senior Lecturer in Obstetrics (Public, Global and D
 
 
 
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Contact

 

edward.mullins Website CV

 
 
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Location

 

St Mary's HospitalClarence WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Stampalija:2020:10.1002/uog.22125,
author = {Stampalija, T and Thornton, J and Marlow, N and Napolitano, R and Bhide, A and Pickles, T and Bilardo, CM and Gordijn, SJ and Gyselaers, W and Valensise, H and Hecher, K and Sande, RK and Lindgren, P and Bergman, E and Arabin, B and Breeze, AC and Wee, L and Ganzevoort, W and Richter, J and Berger, A and Brodszki, J and Derks, J and Mecacci, F and Maruotti, GM and Myklestad, K and Lobmaier, SM and Prefumo, F and Klaritsch, P and Calda, P and Ebbing, C and Frusca, T and Raio, L and Visser, GHA and Krofta, L and Cetin, I and Ferrazzi, E and Cesari, E and Wolf, H and Lees, CC},
doi = {10.1002/uog.22125},
journal = {Ultrasound in Obstetrics and Gynecology},
pages = {173--181},
title = {Fetal cerebral Doppler changes and outcome in late preterm fetal growth restriction: prospective cohort study},
url = {http://dx.doi.org/10.1002/uog.22125},
volume = {56},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectivesTo explore the association between fetal umbilical and middle cerebral artery (MCA) Doppler abnormalities and outcome in late preterm pregnancies at risk of fetal growth restriction.MethodsThis was a prospective cohort study of singleton pregnancies at risk of fetal growth restriction at 32 + 0 to 36 + 6 weeks of gestation, enrolled in 33 European centers between 2017 and 2018, in which umbilical and fetal MCA Doppler velocimetry was performed. Pregnancies were considered at risk of fetal growth restriction if they had estimated fetal weight and/or abdominal circumference (AC) < 10th percentile, abnormal arterial Doppler and/or a fall in AC growth velocity of more than 40 percentile points from the 20week scan. Composite adverse outcome comprised both immediate adverse birth outcome and major neonatal morbidity. Using a range of cutoff values, the association of MCA pulsatility index and umbilicocerebral ratio (UCR) with composite adverse outcome was explored.ResultsThe study population comprised 856 women. There were two (0.2%) intrauterine deaths. Median gestational age at delivery was 38 (interquartile range (IQR), 37–39) weeks and birth weight was 2478 (IQR, 2140–2790) g. Compared with infants with normal outcome, those with composite adverse outcome (n = 93; 11%) were delivered at an earlier gestational age (36 vs 38 weeks) and had a lower birth weight (1900 vs 2540 g). The first Doppler observation of MCA pulsatility index < 5th percentile and UCR Zscore above gestationalagespecific thresholds (1.5 at 32–33 weeks and 1.0 at 34–36 weeks) had the highest relative risks (RR) for composite adverse outcome (RR 2.2 (95% CI, 1.5–3.2) and RR 2.0 (95% CI, 1.4–3.0), respectively). After adjustment for confounders, the association between UCR Zscore and composite adverse outcome remained significa
AU  - Stampalija,T
AU  - Thornton,J
AU  - Marlow,N
AU  - Napolitano,R
AU  - Bhide,A
AU  - Pickles,T
AU  - Bilardo,CM
AU  - Gordijn,SJ
AU  - Gyselaers,W
AU  - Valensise,H
AU  - Hecher,K
AU  - Sande,RK
AU  - Lindgren,P
AU  - Bergman,E
AU  - Arabin,B
AU  - Breeze,AC
AU  - Wee,L
AU  - Ganzevoort,W
AU  - Richter,J
AU  - Berger,A
AU  - Brodszki,J
AU  - Derks,J
AU  - Mecacci,F
AU  - Maruotti,GM
AU  - Myklestad,K
AU  - Lobmaier,SM
AU  - Prefumo,F
AU  - Klaritsch,P
AU  - Calda,P
AU  - Ebbing,C
AU  - Frusca,T
AU  - Raio,L
AU  - Visser,GHA
AU  - Krofta,L
AU  - Cetin,I
AU  - Ferrazzi,E
AU  - Cesari,E
AU  - Wolf,H
AU  - Lees,CC
DO  - 10.1002/uog.22125
EP  - 181
PY  - 2020///
SN  - 0960-7692
SP  - 173
TI  - Fetal cerebral Doppler changes and outcome in late preterm fetal growth restriction: prospective cohort study
T2  - Ultrasound in Obstetrics and Gynecology
UR  - http://dx.doi.org/10.1002/uog.22125
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000554747100004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://obgyn.onlinelibrary.wiley.com/doi/full/10.1002/uog.22125
UR  - http://hdl.handle.net/10044/1/83945
VL  - 56
ER  -
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