Imperial College London
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DrEdwardMullins

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Senior Lecturer in Obstetrics (Public, Global and D
 
 
 
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Contact

 

edward.mullins Website CV

 
 
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Location

 

St Mary's HospitalClarence WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Osman:2024:10.1097/HJH.0000000000003562,
author = {Osman, MMA and Mullins, E and Kleprlikova, H and Wilkinson, IB and Lees, C},
doi = {10.1097/HJH.0000000000003562},
journal = {Journal of Hypertension},
pages = {101--108},
title = {Beetroot juice, exercise, and cardiovascular function in women planning to conceive},
url = {http://dx.doi.org/10.1097/HJH.0000000000003562},
volume = {42},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: Prepregnancy optimization of cardiovascular function may reduce the risk of pre-eclampsia. We aimed to assess the feasibility and effect of preconception cardiovascular monitoring, exercise, and beetroot juice on cardiovascular parameters in women planning to conceive. DESIGN AND METHOD: Prospective single-site, open-label, randomized controlled trial. Thirty-two women, aged 18-45 years, were allocated into one of four arms (1:1:1:1): exercise, beetroot juice, exercise plus beetroot juice and no intervention for 12 weeks. Blood pressure (BP) was measured at home daily. Cardiac output (CO) and total peripheral resistance (TPR) were assessed via bio-impedance. RESULTS: Twenty-nine out of 32 (91%) participants completed the study. Adherence to daily BP and weight measurements were 81 and 78%, respectively (n=29). Eight out of 15 (53%) of participants did not drink all the provided beetroot juice because of forgetfulness and taste. After 12 weeks, exercise was associated with a reduction in standing TPR (-278±0.272dynesscm-5, P<0.05), and an increase in standing CO (+0.88±0.71l/min, P<0.05). Exercise and beetroot juice together was associated with a reduction in standing DBP (7±6mmHg, P<0.05), and an increase in standing CO (+0.49±0.66l/min, P<0.05). The control group showed a reduction in standing TPR (313±387dynesscm-5) and standing DBP (8±5mmHg). All groups gained weight. CONCLUSION: Exercise and beetroot juice in combination showed a signal towards improving cardiovascular parameters. The control group showed improvements, indicating that home measurement devices and regular recording of parameters are interventions in themselves. Nevertheless, interventions before pregnancy to improve cardiovascular parameters may alter the occurrence of hypertensive conditions during pregnancy and require further investigation in adequately powered studies.
AU  - Osman,MMA
AU  - Mullins,E
AU  - Kleprlikova,H
AU  - Wilkinson,IB
AU  - Lees,C
DO  - 10.1097/HJH.0000000000003562
EP  - 108
PY  - 2024///
SN  - 0263-6352
SP  - 101
TI  - Beetroot juice, exercise, and cardiovascular function in women planning to conceive
T2  - Journal of Hypertension
UR  - http://dx.doi.org/10.1097/HJH.0000000000003562
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37728100
UR  - https://journals.lww.com/jhypertension/fulltext/9900/beetroot_juice,_exercise,_and_cardiovascular.324.aspx
UR  - http://hdl.handle.net/10044/1/106613
VL  - 42
ER  -
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