I am Senior Lectuer in Genomic Medicine at Imperial College Faculty of Medicine and I lead the Integrative Genomics and Medicine Group of the MRC Institute of Clinical Sciences, which is based on the Hammersmith campus of Imperial College London (http://www.csc.mrc.ac.uk/Research/Groups/GMC/IntegrativeGenomicsMedicine/).
Our research focuses on the integration of genomic, phenotypic and genetic resources to identify risk factors and molecular networks for complex traits and disease.
Understanding how complex disease systems operate requires the integration of multiple layers of biological information from DNA to phenotype. In my group, we integrate informatics and multi-dimensional modelling of genomic data to elucidate the regulatory processes underlying complex traits, including metabolic, cardiovascular, inflammatory, neurological and behavioral phenotypes.
In particular, rather than focusing on single disease susceptibility genes, we explore pathways and networks to better predict the consequences of genetic and epigenetic variations on complex disease. We employ systems-genetics approaches, from model organisms to humans, to provide functional annotation of genes in biological processes and reveal the signal of common genetic variation of small effect that is not captured by typical genome wide association studies.
et al., 2020, Whole-Genome Sequencing of Finnish Type 1 Diabetic Siblings Discordant for Kidney Disease Reveals DNA Variants associated with Diabetic Nephropathy., J Am Soc Nephrol, Vol:31, Pages:309-323
et al., 2020, Genome-wide meta-analysis associates GPSM1 with type 2 diabetes, a plausible gene involved in skeletal muscle function, Journal of Human Genetics, ISSN:1434-5161
et al., 2019, A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation, Nature Neuroscience, Vol:22, ISSN:1097-6256, Pages:2087-+
et al., 2019, Broad regulation of gene isoform expression by Wnt signaling in cancer, Rna, Vol:25, ISSN:1355-8382, Pages:1696-1713
et al., 2019, Impaired secretion of clusterin in pericardial fluid of diabetics, a deleterious outcome for the cardiac micro-vasculature, ESC Congress / World Congress of Cardiology, OXFORD UNIV PRESS, Pages:3912-3912, ISSN:0195-668X