Imperial College London
Alternate

ProfessorEricAboagye

Faculty of Medicine, Department of Surgery & Cancer

Professor
 
 
 
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Contact

 

eric.aboagye

 
 
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Assistant

 

Mrs Maureen Francis +44 (0)20 7594 2793

 
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Location

 

GN1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Allott:2019:10.1039/c9re00226j,
author = {Allott, L and Barnes, C and Brickute, D and Leung, SFJ and Aboagye, EO},
doi = {10.1039/c9re00226j},
journal = {Reaction Chemistry and Engineering},
pages = {1748--1751},
title = {Solid-supported cyanoborohydride cartridges for automation of reductive amination radiochemistry},
url = {http://dx.doi.org/10.1039/c9re00226j},
volume = {4},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A solid-supported cyanoborohydride cartridge was designed to facilitate the automated production of positron emission tomography (PET) radiotracers synthesised via reductive amination chemistry. Two compounds, N-(4-fluorobenzyl)-2-(2-nitro-1H-imidazol-1-yl)ethan-1-amine ([18F]2) and 1,3,4,6-tetra-O-acetyl-2-(4-fluorobenzylamine)-2-deoxy-β-D-glucopyranose ([18F]4) were radiosynthesised efficiently using a GE FASTlab™ platform, obtained in >98% RCP in a total synthesis time of 75 min (from the start of synthesis) with RCY (non-decay corrected) of 7.5 ± 2.5% and 6.0 ± 1.1%, respectively. The cartridge method provides a convenient alternative to conventional powdered reducing agents typically used in reductive amination radiochemistry.
AU  - Allott,L
AU  - Barnes,C
AU  - Brickute,D
AU  - Leung,SFJ
AU  - Aboagye,EO
DO  - 10.1039/c9re00226j
EP  - 1751
PY  - 2019///
SN  - 2058-9883
SP  - 1748
TI  - Solid-supported cyanoborohydride cartridges for automation of reductive amination radiochemistry
T2  - Reaction Chemistry and Engineering
UR  - http://dx.doi.org/10.1039/c9re00226j
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000487966300002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubs.rsc.org/en/content/articlelanding/2019/RE/C9RE00226J#!divAbstract
UR  - http://hdl.handle.net/10044/1/81738
VL  - 4
ER  -
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