Overview
- Development of a combined meningococcal-pneumococcal vaccine (in collaboration with Brendan Wren and Jon Cuccui of LSHTM)
- Analysis of the functional human adaptive immunity to Neisseria meningitidis following pharyngeal challenge with the commensal, Neisseria lactamica (in collaboration with Robert Read and Adam Dale of University of Southampton)
- Gonococcal molecular biology and development of therapeutics to combat antimicrobial-resistant gonococci
Collaborators
Professor Robert ReadDr Adam Dale, University of Southampton, Neisserial immunology, 2020
Professor David GoldblattDr Helen Wagstaffe, University College London, Group A Streptococcal immunology, 2019
Professor Brendan WrenDr Jon Cuccui, London School of Hygiene and Tropical Medicine (LSHTM), Bacterial glycoengineering, 2017
Research Student Supervision
Davies,C, Identification and cloning of fully-human monoclonal antibodies (hmAbs) from pneumococcal-specific human memory B cells.
Gladstone,C, Optimisation of recombinant expression of human antibodies and their use to derive vaccines for infectious diseases: meningococcal disease as an exemplar
Mendes,J, Human cellular and humoral responses to a recombinant meningococcal glycoprotein
O'Leary,S, Towards Understanding the Human Antimeningococcal Immune Response Elicited by Neisseria Lactamica
Siris,S, Identification of pneumococcal vaccine antigens using Reverse Vaccinology 2.0