Imperial College London

Professor Francis Drobniewski

Faculty of MedicineDepartment of Medicine

Chair in Global Health and Tuberculosis
 
 
 
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Contact

 

f.drobniewski

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

265 results found

Broda A, Nikolayevskyy V, Casali N, Khan H, Bowker R, Blackwell G, Patel B, Hume J, Hussain W, Drobniewski Fet al., 2018, Experimental platform utilising melting curve technology for detection of mutations in Mycobacterium tuberculosis isolates, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, Vol: 37, Pages: 1273-1279, ISSN: 0934-9723

JOURNAL ARTICLE

Chongwe G, Michelo C, Sinkala E, Kayamba V, Nzayisenga J-B, Drobniewski F, Kelly Pet al., 2018, Mycobacterium avium lysate induces matrix metalloproteinase-1 in intestinal tissue and peripheral blood: Observations from selected hospital based Zambian adults, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, Vol: 71, Pages: 73-81, ISSN: 1201-9712

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Jackson C, Southern J, Lalvani A, Drobniewski F, Griffiths CJ, Lipman M, Bothamley GH, Deeks JJ, Imran A, Kon OM, Mpofu S, Nikolayevskyy V, Rees-Roberts M, Sitch A, Sridhar S, Tsou C-Y, Whitworth H, Abubakar Iet al., 2018, Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort., Thorax

We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95% CI 1.02 to 1.30, p=0.025). TRIAL REGISTRATION NUMBER: PREDICT is registered on clinicaltrials.gov (NCT01162265).

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Lalor MK, Casali N, Walker TM, Anderson LF, Davidson JA, Ratna N, Mullarkey C, Gent M, Foster K, Brown T, Magee J, Barrett A, Crook DW, Drobniewski F, Thomas HL, Abubakar Iet al., 2018, The use of whole-genome sequencing in cluster investigation of an MDR-TB outbreak, European Respiratory Journal, Vol: 51, ISSN: 0903-1936

We used whole-genome sequencing to delineate transmission networks and investigate the benefits of whole-genome sequencing during cluster investigation.We included clustered cases of M/XDR-TB linked by MIRU-VNTR, or epidemiological information in the national cluster B1006, notified between 2007-2013 in the UK. We excluded cases whose isolates differed by >12 SNPs from further investigation. Data relating to patients’ social networks were collected.Twenty-seven cases were investigated, 22 had whole-genome sequencing; 8 (36%) of which were excluded as their isolates differed by >12 SNPs to other cases. Eighteen cases were ruled into the transmission network based on genomic and epidemiological information. Evidence of transmission was inconclusive in 39% (7/18) of cases in the transmission network following whole-genome sequencing and epidemiological investigation. This investigation of a drug resistant TB cluster illustrates the opportunities and limitations of whole-genome sequencing in understanding transmission in a setting with a high proportion of migrant cases. The use of WGS should be combined with classical epidemiological methods. However not every cluster will be solvable, regardless of the quality of genomic data.

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Mathys V, Roycroft E, Raftery P, Groenheit R, Folkvardsen DB, Homorodean D, Vasiliauskiene E, Vasiliauskaite L, Kodmon C, van der Werf MJ, Drobniewski F, Nikolayevskyy Vet al., 2018, Time-and-motion tool for the assessment of working time in tuberculosis laboratories: a multicentre study, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 22, Pages: 444-+, ISSN: 1027-3719

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Vella V, Broda A, Drobniewski F, 2018, Should all suspected tuberculosis cases in high income countries be tested with GeneXpert?, TUBERCULOSIS, Vol: 110, Pages: 112-120, ISSN: 1472-9792

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Abubakar I, Drobniewski F, Southern J, Sitch AJ, Jackson C, Lipman M, Deeks JJ, Griffiths C, Bothamley G, Lynn W, Burgess H, Mann B, Imran A, Sridhar S, Tsou CY, Nikolayevskyy V, Rees-Roberts M, Whitworth H, Kon OM, Haldar P, Kunst H, Anderson S, Hayward A, Watson JM, Milburn H, Lalvani Aet al., 2017, PROGNOSTIC VALUE OF INTERFERON GAMMA RELEASE ASSAYS AND TUBERCULIN SKIN TEST IN PREDICTING THE DEVELOPMENT OF ACTIVE TUBERCULOSIS: THE UK PREDICT TB COHORT STUDY, THORAX, Vol: 72, Pages: A22-A22, ISSN: 0040-6376

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Balabanova Y, Fiebig L, Ignatyeva O, Riekstina V, Danilovits M, Jaama K, Davidaviciene E, Radiulyte B, Popa CM, Nikolayevskyy V, Drobniewski Fet al., 2017, Multidrug-resistant TB in Eastern region of the EU: is the shorter regimen an exception or a rule?, THORAX, Vol: 72, Pages: 850-852, ISSN: 0040-6376

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Bielecka MK, Tezera LB, Zmijan R, Drobniewski F, Zhang X, Jayasinghe S, Elkington Pet al., 2017, A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis, MBIO, Vol: 8, ISSN: 2150-7511

JOURNAL ARTICLE

Black AT, Hamblion EL, Buttivant H, Anderson SR, Stone M, Casali N, Drobniewski F, Nwoguh F, Marshall BG, Booth Let al., 2017, Tracking and responding to an outbreak of tuberculosis using MIRU-VNTR genotyping and whole genome sequencing as epidemiological tools., J Public Health (Oxf), Pages: 1-8

Background: We describe an outbreak that contributed to a near doubling of the incidence of tuberculosis in Southampton, UK. We examine the importance of 24 locus mycobacterial interspersed repetitive unit variable number tandem repeat (MIRU-VNTR) genotyping in its identification and management and the role of whole genome sequencing (WGS) in tracing the spread of the strain. Methods: Outbreak cases were defined as those diagnosed between January and December 2011 with indistinguishable 24 locus-MIRU-VNTR genotypes or, cases linked epidemiologically. A cluster questionnaire was administered by TB nurses to identify contacts and social settings. Results: Overall, 25 patients fulfilled the case definition. No cases with this MIRU-VNTR genotype had been detected in the UK previously. Connections were found between all cases through household contacts or social venues including a football club, Internet cafe and barber's shop. Public health actions included extended contact tracing, venue screening and TB awareness-raising. The outbreak resulted in a high rate of transmission and high incidence of clinical disease among contacts. Conclusions: This outbreak illustrates the value of combining active case-finding with prospective MIRU-VNTR genotyping to identify settings to undertake public health action. In addition WGS revealed that the VNTR-defined cluster was a single outbreak and that active TB transmission not reactivation was responsible for this outbreak in non-UK born individuals.

JOURNAL ARTICLE

Drobniewski F, Ehsani S, Dara M, 2017, Fighting drug-resistant tuberculosis in eastern Europe, LANCET INFECTIOUS DISEASES, Vol: 17, Pages: 691-692, ISSN: 1473-3099

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Gonzalo X, Claxton P, Brown T, Montgomery L, Fitzgibbon M, Laurenson I, Drobniewski Fet al., 2017, True rifampicin resistance missed by the MGIT: prevalence of this pheno/genotype in the UK and Ireland after 18 month surveillance, CLINICAL MICROBIOLOGY AND INFECTION, Vol: 23, Pages: 260-263, ISSN: 1198-743X

JOURNAL ARTICLE

Kontsevaya I, Nikolayevskyy V, Kovalyov A, Ignatyeva O, Sadykhova A, Simak T, Tikhonova O, Dubrovskaya Y, Vasiliauskiene E, Davidaviciene E, Skenders G, Makurina O, Balabanova Y, Drobniewski Fet al., 2017, Tuberculosis cases caused by heterogeneous infection in Eastern Europe and their influence on outcomes, INFECTION GENETICS AND EVOLUTION, Vol: 48, Pages: 76-82, ISSN: 1567-1348

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Papaventsis D, Casali N, Kontsevaya I, Drobniewski F, Cirillo DM, Nikolayevskyy Vet al., 2017, Whole genome sequencing of Mycobacterium tuberculosis for detection of drug resistance: a systematic review, CLINICAL MICROBIOLOGY AND INFECTION, Vol: 23, Pages: 61-68, ISSN: 1198-743X

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Zheng X, Ning Z, Drobniewski F, Yang J, Li Q, Zhang Z, Hu Yet al., 2017, pncA mutations are associated with slower sputum conversion during standard treatment of multidrug-resistant tuberculosis, INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, Vol: 49, Pages: 183-188, ISSN: 0924-8579

JOURNAL ARTICLE

Balabanova Y, Ignatyeva O, Fiebig L, Riekstina V, Danilovits M, Jaama K, Davidaviciene E, Radiulyte B, Popa CM, Nikolayevskyy V, Drobniewski Fet al., 2016, Survival of patients with multidrug-resistant TB in Eastern Europe: what makes a difference?, THORAX, Vol: 71, Pages: 854-861, ISSN: 0040-6376

JOURNAL ARTICLE

Casali N, Broda A, Harris SR, Parkhill J, Brown T, Drobniewski Fet al., 2016, Whole Genome Sequence Analysis of a Large Isoniazid-Resistant Tuberculosis Outbreak in London: A Retrospective Observational Study, PLOS MEDICINE, Vol: 13, ISSN: 1549-1676

JOURNAL ARTICLE

Li D, Hu Y, Werngren J, Mansjo M, Zheng X, Drobniewski F, Hoffner S, Xu Bet al., 2016, Multicenter Study of the Emergence and Genetic Characteristics of Pyrazinamide-Resistant Tuberculosis in China, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol: 60, Pages: 5159-5166, ISSN: 0066-4804

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Nikolayevskyy V, Hillemann D, Richter E, Ahmed N, van der Werf MJ, Kodmon C, Drobniewski F, Ruesch-Gerdes Set al., 2016, External Quality Assessment for Tuberculosis Diagnosis and Drug Resistance in the European Union: A Five Year Multicentre Implementation Study, PLOS ONE, Vol: 11, ISSN: 1932-6203

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Nikolayevskyy V, Kranzer K, Niemann S, Drobniewski Fet al., 2016, Whole genome sequencing of Mycobacterium tuberculosis for detection of recent transmission and tracing outbreaks: A systematic review, TUBERCULOSIS, Vol: 98, Pages: 77-85, ISSN: 1472-9792

JOURNAL ARTICLE

Nikolayevskyy V, Trovato A, Broda A, Borroni E, Cirillo D, Drobniewski Fet al., 2016, MIRU-VNTR Genotyping of Mycobacterium tuberculosis Strains Using QIAxcel Technology: A Multicentre Evaluation Study, PLOS ONE, Vol: 11, ISSN: 1932-6203

JOURNAL ARTICLE

Pink F, Brown TJ, Kranzer K, Drobniewski Fet al., 2016, Evaluation of Xpert MTB/RIF for Detection of Mycobacterium tuberculosis in Cerebrospinal Fluid, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 54, Pages: 809-811, ISSN: 0095-1137

JOURNAL ARTICLE

Balabanova Y, Nikolayevskyy V, Ignatyeva O, Kontsevaya I, Mironova S, Kovalyov A, Kritsky A, Rodionova Y, Fedorin I, Casali N, Hooper R, Horstmann RD, Nejentsev S, Hoffner S, Nuernberg P, Drobniewski Fet al., 2015, Beijing clades of Mycobacterium tuberculosis are associated with differential survival in HIV-negative Russian patients, INFECTION GENETICS AND EVOLUTION, Vol: 36, Pages: 517-523, ISSN: 1567-1348

JOURNAL ARTICLE

Brown AC, Bryant JM, Einer-Jensen K, Holdstock J, Houniet DT, Chan JZM, Depledge DP, Nikolayevskyy V, Broda A, Stone MJ, Christiansen MT, Williams R, McAndrew MB, Tutill H, Brown J, Melzer M, Rosmarin C, McHugh TD, Shorten RJ, Drobniewski F, Speight G, Breuer Jet al., 2015, Rapid Whole-Genome Sequencing of Mycobacterium tuberculosis Isolates Directly from Clinical Samples, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 53, Pages: 2230-2237, ISSN: 0095-1137

JOURNAL ARTICLE

Cabibbe AM, Miotto P, Moure R, Alcaide F, Feuerriegel S, Pozzi G, Nikolayevskyy V, Drobniewski F, Niemann S, Reither K, Cirillo DMet al., 2015, Lab-on-Chip-Based Platform for Fast Molecular Diagnosis of Multidrug-Resistant Tuberculosis, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 53, Pages: 3876-3880, ISSN: 0095-1137

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Curtis J, Luo Y, Zenner HL, Cuchet-Lourenco D, Wu C, Lo K, Maes M, Alisaac A, Stebbings E, Liu JZ, Kopanitsa L, Ignatyeva O, Balabanova Y, Nikolayevskyy V, Baessmann I, Thye T, Meyer CG, Nuernberg P, Horstmann RD, Drobniewski F, Plagnol V, Barrett JC, Nejentsev Set al., 2015, Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration, NATURE GENETICS, Vol: 47, Pages: 523-U128, ISSN: 1061-4036

JOURNAL ARTICLE

Drobniewski F, Cooke M, Jordan J, Casali N, Mugwagwa T, Broda A, Townsend C, Sivaramakrishnan A, Green N, Jit M, Lipman M, Lord J, White PJ, Abubakar Iet al., 2015, Systematic review, meta-analysis and economic modelling of molecular diagnostic tests for antibiotic resistance in tuberculosis, Health Technology Assessment, Vol: 19, ISSN: 1366-5278

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Gonzaloa X, Casali N, Broda A, Pardieu C, Drobniewski Fet al., 2015, Combination of amikacin and doxycycline against multidrug-resistant and extensively drug-resistant tuberculosis, INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, Vol: 45, Pages: 406-412, ISSN: 0924-8579

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Ignatyeva O, Balabanova Y, Nikolayevskyy V, Koshkarova E, Radiulyte B, Davidaviciene E, Riekstina V, Jaama K, Danilovits M, Popa CM, Drobniewski FAet al., 2015, Resistance profile and risk factors of drug resistant tuberculosis in the Baltic countries, TUBERCULOSIS, Vol: 95, Pages: 581-588, ISSN: 1472-9792

JOURNAL ARTICLE

Kranzer K, Elamin WF, Cox H, Seddon JA, Ford N, Drobniewski Fet al., 2015, A systematic review and meta-analysis of the efficacy and safety of N-acetylcysteine in preventing aminoglycoside-induced ototoxicity: implications for the treatment of multidrug-resistant TB, THORAX, Vol: 70, Pages: 1070-1077, ISSN: 0040-6376

JOURNAL ARTICLE

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