Publications
297 results found
Drobniewski F, Ruesch-Gerdes S, Hoffner S, 2007, Antimicrobial susceptibility testing of <i>Mycobacterium tuberculosis</i> (EUCAST document E.DEF 8.1) -: Report of the subcommittee on antimicrobial susceptibility testing of <i>Mycobacterium tuberculosis</i> of the European Committee for Antimicrobial Susceptibility Testing (EUCAST) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), CLINICAL MICROBIOLOGY AND INFECTION, Vol: 13, Pages: 1144-1156, ISSN: 1198-743X
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- Citations: 33
Drobniewski F, Cobelens F, Zellweger J-P, et al., 2007, Use of Gamma-interferon assays in low- and medium-prevalence countries in Europe: a consensus statement of a Wolfheze Workshop organised by KNCV/EuroTB, Vilnius Sept 2006., Euro Surveill, Vol: 12
Szeszko JS, Healy B, Stevens H, et al., 2007, Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis, HUMAN GENETICS, Vol: 121, Pages: 155-160, ISSN: 0340-6717
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- Citations: 28
Atun RA, Lebcir RM, Drobniewski F, et al., 2007, High coverage with HAART is required to substantially reduce the number of deaths from tuberculosis: system dynamics simulation, INTERNATIONAL JOURNAL OF STD & AIDS, Vol: 18, Pages: 267-273, ISSN: 0956-4624
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- Citations: 14
Shah NS, Shah NS, Shah NS, et al., 2007, Worldwide emergence of extensively drug-resistant tuberculosis, Emerging Infectious Diseases, Vol: 13, Pages: 380-387, ISSN: 1080-6059
Mycobacterium tuberculosis strains that are resistant to an increasing number of second-line drugs used to treat multidrug-resistant tuberculosis (MDR TB) are becoming a threat to public health worldwide. We surveyed the Network of Supranational Reference Laboratories for M. tuberculosis isolates that were resistant to second-line anti-TB drugs during 2000-2004. We defined extensively drug-resistant TB (XDR TB) as MDR TB with further resistance to ≥3 of the 6 classes of second-line drugs. Of 23 eligible laboratories, 14 (61%) contributed data on 17,690 isolates, which reflected drug susceptibility results from 48 countries. Of 3,520 (19.9%) MDR TB isolates, 347 (9.9%) met criteria for XDR TB. Further investigation of population-based trends and expanded efforts to prevent drug resistance and effectively treat patients with MDR TB are crucial for protection of public health and control of TB.
Drobniewski F, Balabanova Y, Balabanova Y, et al., 2007, Rates of latent tuberculosis in health care staff in Russia, Plos Medicine, Vol: 4, Pages: 0273-0279, ISSN: 1549-1676
Background: Russia is one of 22 high burden tuberculosis (TB) countries. Identifying individuals, particularly health care workers (HCWs) with latent tuberculosis infection (LTBI), and determining the rate of infection, can assist TB control through chemoprophylaxis and improving institutional cross-infection strategies. The objective of the study was to estimate the prevalence and determine the relative risks and risk factors for infection, within a vertically organised TB service in a country with universal bacille Calmette-Gué rin (BCG) vaccination. Methods and Findings: We conducted a cross-sectional study to assess the prevalence of and risk factors for LTBI among unexposed students, minimally exposed medical students, primary care health providers, and TB hospital health providers in Samara, Russian Federation. We used a novel in vitro assay (for gamma-interferon [IFN-γ]) release to establish LTBI and a questionnaire to address risk factors. LTBI was seen in 40.8% (107/262) of staff and was significantly higher in doctors and nurses (39.1% [90/230]) than in students (8.7% [32/368]) (relative risk [RR] 4.5; 95% confidence interval [CI] 3.1-6.5) and in TB service versus primary health doctors and nurses: respectively 46.9% (45/96) versus 29.3% (34/116) (RR 1.6; 95% CI 1.1-2.3). There was a gradient of LTBI, proportional to exposure, in medical students, primary health care providers, and TB doctors: respectively, 10.1% (24/238), 25.5% (14/55), and 55% (22/40). LTBI was also high in TB laboratory workers: 11/18 (61.1%). Conclusions: IFN-γ assays have a useful role in screening HCWs with a high risk of LTBI and who are BCG vaccinated. TB HCWs were at significantly higher risk of having LTBI. Larger cohort studies are needed to evaluate the individual risks of active TB development in positive individuals and the effectiveness of preventive therapy based on IFN-γ test results. © 2007 Drobniewski et al.
Nikolayevskyy VV, Brown TJ, Bazhora YI, et al., 2007, Molecular epidemiology and prevalence of mutations conferring rifampicin and isoniazid resistance in <i>Mycobacterium tuberculosis</i> strains from the southern Ukraine, CLINICAL MICROBIOLOGY AND INFECTION, Vol: 13, Pages: 129-138, ISSN: 1198-743X
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- Citations: 37
Dinnes J, Deeks J, Kunst H, et al., 2007, A systematic review of rapid diagnostic tests for the detection of tuberculosis infection., Health Technol Assess, Vol: 11, Pages: 1-196, ISSN: 1366-5278
OBJECTIVES: To evaluate the effectiveness of available rapid diagnostic tests to identify tuberculosis (TB) infection. DATA SOURCES: Electronic databases were searched from 1975 to August 2003 for tests for active TB and to March 2004 for tests for latent tuberculosis infection (LTBI). REVIEW METHODS: Studies were selected and evaluated that (1) tested for LTBI, (2) compared tuberculin skin test (TST) and interferon-gamma assays based on ESAT-6 and CFP-10 antigens and (3) provided information on TB exposure or bacille Calmette-Guerin (BCG) vaccination or HIV status. For each test comparison, the sensitivity, specificity and 95% confidence intervals (CIs) were calculated. Sources of heterogeneity were investigated by adding covariates to the standard regression model. The authors examined whether interferon-gamma assays were more strongly associated with high versus low TB exposure than TST. Odds ratios (ORs) were calculated for the association between test results and exposures from each study along with their 95% CIs. Within each study, the OR value for one test was divided by that for another to produce a ratio of OR (ROR). RESULTS: A total of 212 studies were included, providing 368 data sets. A further 19 studies assessing fully automated liquid culture were included. Overall, nucleic acid amplification test (NAAT) accuracy was far superior when applied to respiratory samples as opposed to other body fluids. The better quality in-house studies, were, for pulmonary TB, much better at ruling out TB than the commercial tests (higher sensitivity), but were less good at ruling it in (lower specificity), but it is not possible to recommend any one over another owing to a lack of direct test comparisons. The specificity of NAAT tests was high when applied to body fluids, for example for TB meningitis and pleural TB, but sensitivity was poor, indicating that these tests cannot be used reliably to rule out TB. High specificity estimates suggest that NAAT tests should be
Dinnes J, Deeks J, Kunst H, et al., 2007, A systematic review of rapid diagnostic tests for the detection of tuberculosis infection, HEALTH TECHNOLOGY ASSESSMENT, Vol: 11, Pages: 1-+, ISSN: 1366-5278
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- Citations: 357
Drobniewski FA, Hoffner S, Rusch-Gerdes S, et al., 2006, Recommended standards for modern tuberculosis laboratory services in Europe, EUROPEAN RESPIRATORY JOURNAL, Vol: 28, Pages: 903-909, ISSN: 0903-1936
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- Citations: 34
Balabanova Y, Coker R, Atun RA, et al., 2006, Stigma and HIV infection in Russia, AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, Vol: 18, Pages: 846-852, ISSN: 0954-0121
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- Citations: 42
Nikolayevskyy V, Gopaul K, Balabanova Y, et al., 2006, Differentiation of tuberculosis strains in a population with mainly Beijing-family strains, EMERGING INFECTIOUS DISEASES, Vol: 12, Pages: 1406-1413, ISSN: 1080-6040
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- Citations: 37
Atun RA, Samyshkin Y, Drobniewski F, et al., 2006, Costs and outcomes of tuberculosis control in the Russian Federation: retrospective cohort analysis, HEALTH POLICY AND PLANNING, Vol: 21, Pages: 353-364, ISSN: 0268-1080
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- Citations: 16
Nikolayevskyy V, Gopaul K, Balabanova Y, et al., 2006, Differentiation of tuberculosis strains in a population with mainly Beijing-family strains., Emerg Infect Dis, Vol: 12, Pages: 1406-1413, ISSN: 1080-6040
A high prevalence of tuberculosis (TB) isolates that are genetically homogenous and from the Beijing family has been reported in Russia. To map TB transmission caused by these strains, new genotyping systems are needed. Mycobacterial interspersed repetitive units (MIRUs) offer the possibility of rapid PCR-based typing with comparable discrimination to IS6110 restriction fragment length polymorphism techniques. Spoligotyping and detection of IS6110 insertion in the dnaA-dnaN region were used to identify Beijing strains in 187 Mycobacterium tuberculosis isolates from Samara, Russia. The Beijing isolates were analyzed by using 12-MIRU and 3-exact tandem repeats (ETR) loci and by an expanded set of 10 additional variable number tandem repeats loci. The expanded set of 25 MIRUs provided better discrimination than the original set of 15 (Hunter-Gaston diversity index 0.870 vs. 0.625). Loci MIRU 26, 1982, and 3232 were the most polymorphic in Beijing isolates.
Davies PDO, Drobniewski F, 2006, The use of interferon-γ-based blood tests for the detection of latent tuberculosis infection, EUROPEAN RESPIRATORY JOURNAL, Vol: 28, Pages: 1-3, ISSN: 0903-1936
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- Citations: 16
Dimitrova B, Balabanova D, Atun R, et al., 2006, Health service providers' perceptions of barriers to tuberculosis care in Russia, HEALTH POLICY AND PLANNING, Vol: 21, Pages: 265-274, ISSN: 0268-1080
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- Citations: 51
Gopaul KK, Brown TJ, Gibson AL, et al., 2006, Progression toward an improved DNA amplification-based typing technique in the study of <i>Mycobacterium tuberculosis</i> epidemiology, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 44, Pages: 2492-2498, ISSN: 0095-1137
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- Citations: 29
Maguire H, Ruddy M, Bothamley G, et al., 2006, Multidrug resistance emerging in North London outbreak, THORAX, Vol: 61, Pages: 547-548, ISSN: 0040-6376
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- Citations: 8
Crampin AC, Glynn JR, Traoré H, et al., 2006, Tuberculosis transmission attributable to close contacts and HIV status, Malawi, Emerging Infectious Diseases, Vol: 12, Pages: 729-735, ISSN: 1080-6059
We conducted the first molecular study of tuberculosis (TB) to estimate the role of household contact and transmission from HIV-positive putative source contacts (PSCs) in a high HIV-prevalence area. TB patients in a long-term population-based study in Malawi were asked about past contact with TB. DNA fingerprinting was used to define clusters of cases with identical strains. Among 143 epidemiologically defined PSC-case pairs, fingerprinting confirmed transmission for 44% of household and family contacts and 18% of other contacts. Transmission was less likely to be confirmed if the PSC were HIV positive than if he or she were HIV negative (odds ratio 0.32, 95% confidence interval [CI] 0.14-0.74). Overall, epidemiologic links were found for 11% of 754 fingerprint-clustered cases. We estimate that 9%-13% of TB cases were attributable to recent transmission from identifiable close contacts and that nearly half of the TB cases arising from recent infection had acquired the infection from HIV-positive patients.
Sam IC, Drobniewski F, More P, et al., 2006, <i>Mycobacterium tuberculosis</i> and rifampin resistance, United kingdom, EMERGING INFECTIOUS DISEASES, Vol: 12, Pages: 752-759, ISSN: 1080-6040
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- Citations: 31
Brown TJ, Herrera-Leon L, Anthony RM, et al., 2006, The use of macroarrays for the identification of MDR <i>Mycobacterium tuberculosis</i>, JOURNAL OF MICROBIOLOGICAL METHODS, Vol: 65, Pages: 294-300, ISSN: 0167-7012
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- Citations: 23
Balabanova Y, Drobniewski F, Fedorin I, et al., 2006, The Directly Observed Therapy Short-Course (DOTS) strategy in Samara Oblast, Russian Federation, Respiratory Research, Vol: 7, ISSN: 1465-993X
Background: The World Health Organisation (WHO) defines Russia as one of the 22 highest-burden countriesfor tuberculosis (TB). The WHO Directly Observed Treatment Short Course (DOTS) strategy employing astandardised treatment for 6 months produces the highest cure rates for drug sensitive TB. The Russian TBservice traditionally employed individualised treatment.The purpose of this study was to implement a DOTS programme in the civilian and prison sectors of SamaraRegion of Russia, describe the clinical features and outcomes of recruited patients, determine the proportion ofindividuals in the cohorts who were infected with drug resistant TB, the degree to which resistance was attributedto the Beijing TB strain family and establish risk factors for drug resistance.Methods: prospective studyResults: 2,099 patients were recruited overall. Treatment outcomes were analysed for patients recruited up tothe third quarter of 2003 (n = 920). 75.3% of patients were successfully treated. Unsuccessful outcomes occurredin 7.3% of cases; 3.6% of patients died during treatment, with a significantly higher proportion of smear-positivecases dying compared to smear-negative cases. 14.0% were lost and transferred out. A high proportion of newcases (948 sequential culture-proven TB cases) had tuberculosis that was resistant to first-line drugs; (24.9%isoniazid resistant; 20.3% rifampicin resistant; 17.3% multidrug resistant tuberculosis). Molecular epidemiologicalanalysis demonstrated that half of all isolated strains (50.7%; 375/740) belonged to the Beijing family. Drugresistance including MDR TB was strongly associated with infection with the Beijing strain (for MDR TB, 35.2%in Beijing strains versus 9.5% in non-Beijing strains, OR-5.2. Risk factors for multidrug resistant tuberculosis were:being a prisoner (OR 4.4), having a relapse of tuberculosis (OR 3.5), being infected with a Beijing family TB strain(OR 6.5) and having an unsuccessful outcome from treatment (OR 5.0).Conclusion: Th
Krüüner A, Yates MD, Drobniewski FA, 2006, Evaluation of MGIT 960-based antimicrobial testing and determination of critical concentrations of first- and second-line antimicrobial drugs with drug-resistant clinical strains of <i>Mycobacterium tuberculosis</i>, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 44, Pages: 811-818, ISSN: 0095-1137
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- Citations: 106
Coker R, McKee M, Atun R, et al., 2006, Risk factors for pulmonary tuberculosis in Russia: case-control study, BRITISH MEDICAL JOURNAL, Vol: 332, Pages: 85-87, ISSN: 0959-8146
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- Citations: 122
Floyd K, Hutubessy R, Samyshkin Y, et al., 2006, Health-systems efficiency in the Russian Federation: tuberculosis control, Bulletin of the World Health Organization, Vol: 84, Pages: 43-51, ISSN: 0042-9686
Gibson A, Brown T, Baker L, et al., 2005, Can 15-locus mycobacterial interspersed repetitive unit-variable-number tandem repeat analysis provide insight into the evolution of <i>Mycobacterium tuberculosis</i>?, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol: 71, Pages: 8207-8213, ISSN: 0099-2240
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- Citations: 24
Coker RJ, Dimitrova B, Drobniewski F, et al., 2005, Health system frailties in tuberculosis service provision in Russia: an analysis through the lens of formal nutritional support, PUBLIC HEALTH, Vol: 119, Pages: 837-843, ISSN: 0033-3506
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- Citations: 10
Balabanova Y, Coker R, Fedorin I, et al., 2005, Variability in interpretation of chest radiographs among Russian clinicians and implications for screening programmes: observational study, BMJ-BRITISH MEDICAL JOURNAL, Vol: 331, Pages: 379-+, ISSN: 1756-1833
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- Citations: 53
Glynn JR, Crampin AC, Yates MD, et al., 2005, The importance of recent infection with <i>Mycobacterium tuberculosis</i> in an area with high HIV prevalence:: A long-term molecular epidemiological study in northern Malawi, JOURNAL OF INFECTIOUS DISEASES, Vol: 192, Pages: 480-487, ISSN: 0022-1899
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- Citations: 60
Drobniewski FA, Balabanova YM, Ruddy MC, et al., 2005, Tuberculosis, HIV seroprevalence and intravenous drug abuse in prisoners, EUROPEAN RESPIRATORY JOURNAL, Vol: 26, Pages: 298-304, ISSN: 0903-1936
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- Citations: 43
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