Imperial College London

Professor Francis Drobniewski

Faculty of MedicineDepartment of Infectious Disease

Chair in Global Health and Tuberculosis
 
 
 
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Contact

 

f.drobniewski

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

297 results found

Atun RA, Lebcir R, Drobniewski F, Coker RJet al., 2005, Impact of an effective multidrug-resistant tuberculosis control programme in the setting of an immature HIV epidemic: system dynamics simulation model, INTERNATIONAL JOURNAL OF STD & AIDS, Vol: 16, Pages: 560-570, ISSN: 0956-4624

Journal article

Drobniewski F, Balabanova Y, Nikolayevsky V, Ruddy M, Kuznetzov S, Zakharova S, Melemyev A, Fedorin Iet al., 2005, Drug-resistant, tuberculosis, clinical virulence, and the dominance of the Beijing strain family in Russia, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 293, Pages: 2726-2731, ISSN: 0098-7484

Journal article

Dale JW, Bothamley GH, Drobniewski F, Gillespie SH, McHugh TD, Pitman Ret al., 2005, Origins and properties of <i>Mycobacterium tuberculosis</i> isolates in London, JOURNAL OF MEDICAL MICROBIOLOGY, Vol: 54, Pages: 575-582, ISSN: 0022-2615

Journal article

Drobniewski F, Nikolayevsky V, Asmolov A, Bazhora Y, Servetsky Set al., 2005, Increasing trends in HIV and TB rates in Odessa and the Ukraine., Int J STD AIDS, Vol: 16, Pages: 374-378, ISSN: 0956-4624

Notification rates for HIV and tuberculosis (TB) have increased in the Ukraine and particularly in Odessa. In 1962, the incidence of TB in Odessa region was 178 cases per 100,000 cases, declining to 73.0, 42.0 and 41.6 cases per 100,000 in 1972, 1982 and 1992, respectively. In 2002, TB incidence and prevalence were 80.4 and 330.1/100,000 population, respectively. TB mortality in the port almost doubled from 10.2/100,000 to 21.6/100,000 between 1990 and 2001. In 2002, the HIV incidence and prevalence and AIDS incidence and prevalence were 46.4 and 241.0 cases/100,000 population and 14.5/100,000 and 26.9/100,000, respectively. There are increasing numbers of TB cases co-infected with HIV (200 in 2002), suggesting that the HIV and TB epidemics are converging. Significant effort is needed for the effective control of these two outbreaks to prevent high levels of morbidity and mortality from these diseases.

Journal article

Drobniewski F, Nikolayevsky V, Asmolov A, Bazhora Y, Servetsky Set al., 2005, Increasing trends in HIV and TB rates in Odessa and the Ukraine, INTERNATIONAL JOURNAL OF STD & AIDS, Vol: 16, Pages: 374-378, ISSN: 0956-4624

Journal article

Baker LV, Brown TJ, Maxwell O, Gibson AL, Fang Z, Yates MD, Drobniewski FAet al., 2005, Molecular analysis of isoniazid-resistant <i>Mycobacterium tuberculosis</i> isolates from England and Wales reveals the phylogenetic significance of the <i>ahpC</i>-46A polymorphism, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol: 49, Pages: 1455-1464, ISSN: 0066-4804

Journal article

Atun RA, Samyshkin YA, Drobniewski F, Skuratova NM, Gusarova G, Kuznetsov SI, Fedorin IM, Coker RJet al., 2005, Barriers to sustainable tuberculosis control in the Russian Federation health system, BULLETIN OF THE WORLD HEALTH ORGANIZATION, Vol: 83, Pages: 217-223, ISSN: 0042-9686

Journal article

Ruddy M, Balabanova Y, Graham C, Fedorin I, Malomanova N, Elisarova E, Kuznetznov S, Gusarova G, Zakharova S, Melentyev A, Krukova E, Golishevskaya V, Erokhin V, Dorozhkova I, Drobniewski Fet al., 2005, Rates of drug resistance and risk factor analysis in civilian and prison patients with tuberculosis in Samara Region, Russia, THORAX, Vol: 60, Pages: 130-135, ISSN: 0040-6376

Journal article

Balabanova Y, Ruddy M, Hubb J, Yates M, Malomanova N, Fedorin I, Drobniewski Fet al., 2005, Multidrug-resistant tuberculosis in Russia: clinical characteristics, analysis of second-line drug resistance and development of standardized therapy, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, Vol: 24, Pages: 136-139, ISSN: 0934-9723

Journal article

Glynn JR, Crampin AC, Traoré H, Yates MD, Mwaungulu FD, Ngwira BMM, Chaguluka SD, Mwafulirwa DT, Floyd S, Murphy CL, Drobniewski FA, Fine PEMet al., 2005, Mycobacterium tuberculosis Beijing genotype, Northern Malawi, Emerging Infectious Diseases, Vol: 11, Pages: 150-153, ISSN: 1080-6040

In a 7-year population-based study in Malawi, we showed that Beijing genotype tuberculosis (TB) increased as a proportion of TB cases. All the Beijing genotype strains were fully drug sensitive. Contact histories, TB type, and case-fatality rates were similar for Beijing and non-Beijing genotype TB.

Journal article

Drobniewski F, 2005, Non-pulmonary mycobacterial infection, Medicine, Vol: 33, Pages: 109-111, ISSN: 1357-3039

Journal article

Dimitrova B, Hutchings A, Atun R, Drobniewski F, Marchenko G, Zakharova S, Fedorin I, Coker RJet al., 2005, Increased risk of tuberculosis among health care workers in Samara Oblast, Russia: analysis of notification data, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 9, Pages: 43-48, ISSN: 1027-3719

Journal article

Atun RA, Samyshkin YA, Drobniewski F, Kuznetsov SI, Fedorin IM, Coker RJet al., 2005, Seasonal variation and hospital utilization for tuberculosis in Russia: hospitals as social care institutions, The European Journal of Public Health, Vol: 15, Pages: 350-354, ISSN: 1101-1262

Journal article

Atun RA, Samyshkin YA, Drobniewski F, Kuznetson S I, Fedorin IM, Coker RJet al., 2005, Social factors influencing hospital utilisation by tuberculosis patients in the Russian Federation: analysis of routinely collected data, International Journal of Tubeculsosis and Lung Disease, Vol: 9, Pages: 1140-1146, ISSN: 1027-3719

Journal article

Atun RA, McKee M, Drobniewski F, Coker Ret al., 2005, Analysis of how the health systems context shapes responses to the control of human immunodeficiency virus: case-studies from the Russian Federation, Bulletin of the World Health Organization, Vol: 83, Pages: 730-738, ISSN: 0042-9686

Journal article

Atun RA, Baeza J, Drobniewski F, Levicheva V, Coker RJet al., 2005, Implementing WHO DOTS strategy in the Russian Federation: stakeholder attitudes, Health Policy, Vol: 74, Pages: 122-132, ISSN: 0168-8510

Journal article

Nikolaevskiĭ VV, Balabanova IM, Brown T, Drobniewski FA, Fedorin IMet al., 2005, [Molecular typing of the Mycobacterium tuberculosis strains circulating in central Russia: efficiency of spoligotyping and VNTR-MIRU]., Mol Gen Mikrobiol Virusol, Pages: 9-14, ISSN: 0208-0613

Current problems of molecular epidemiology of the Mycobacterium tuberculosis strains circulating in Samara Region, Russia are discussed. A total of 190 isolates of Mycobacterium tuberculosis were typed using two PCR-based molecular methods. The cultures were isolated from civil and prison patients with pulmonary tuberculosis recruited from different tuberculosis institutions across the Samara region. The usefulness of spoligotyping and 15-locii VNTR-MIRU was assessed for genotyping of Mycobacterium in population with high prevalence of Beijing strains (67.9%) using statistical analyses that included calculation of Hunter-Gaston index. The VNTR-MIRU method was demonstrated to be more efficient and was characterized by higher discrimination (index 0.747) compare to spoligotyping (index 0.572). VNTR-MIRU loci 10, 26, 31, 39, 40 and ETR-A were mostly polymorphic and therefore recommended for use in screening. It could be performed by manual electrophoresid, provided that automated sequencing is not available.

Journal article

van Altena R, van Soolingen D, van der Werf TS, 2004, Isoniazid resistant TB and non-compliance., Thorax, Vol: 59, ISSN: 0040-6376

Journal article

Conaty SJ, Hayward AC, Story A, Glynn JR, Drobniewski FA, Watson JMet al., 2004, Explaining risk factors for drug-resistant tuberculosis in England and Wales: contribution of primary and secondary drug resistance, EPIDEMIOLOGY AND INFECTION, Vol: 132, Pages: 1099-1108, ISSN: 0950-2688

Journal article

Easterbrook PJ, Gibson A, Murad S, Lamprecht D, Ives N, Ferguson A, Lowe O, Mason P, Ndudzo A, Taziwa A, Makombe R, Mbengeranwa L, Sola C, Rastogi N, Drobniewski Fet al., 2004, High rates of clustering of strains causing tuberculosis in Harare, Zimbabwe: a molecular epidemiological study (vol 42, pg 4536, 2004), JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 42, Pages: 5965-5965, ISSN: 0095-1137

Journal article

Ruddy MC, Yates MD, Drobniewski FA, Davies AP, Drabu Y, Patel B, Yates S, Lozewicz S, Sen S, Bahl M, James E, Lipman M, Balasegaram S, Duckworth G, Watson JM, Piper M, Maguire Het al., 2004, Isoniazid resistant TB and non-compliance - Authors' reply, THORAX, Vol: 59, Pages: 1098-1099, ISSN: 0040-6376

Journal article

Easterbrook PJ, Gibson A, Murad S, Lamprecht D, Ives N, Ferguson A, Lowe O, Mason P, Ndudzo A, Taziwa A, Makombe R, Mbengeranwa L, Sola C, Rostogi N, Drobniewski Fet al., 2004, High rates of clustering of strains causing tuberculosis in harare, Zimbabwe: A molecular epidemiological study, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 42, Pages: 4536-4544, ISSN: 0095-1137

Journal article

Drobniewski FA, Atun R, Fedorin I, Bikov A, Coker Ret al., 2004, The 'bear trap': the colliding epidemics of tuberculosis and HIV in Russia, INTERNATIONAL JOURNAL OF STD & AIDS, Vol: 15, Pages: 641-646, ISSN: 0956-4624

Journal article

Nikolayevsky V, Brown T, Balabanova Y, Ruddy M, Fedorin I, Drobniewski Fet al., 2004, Detection of mutations associated with isoniazid and rifampin resistance in <i>Mycobacterium tuberculosis</i> isolates from Samara region, Russian Federation, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 42, Pages: 4498-4502, ISSN: 0095-1137

Journal article

Glynn JR, Yates MD, Crampin AC, Ngwira BM, Mwaungulu FD, Black GF, Chaguluka SD, Mwafulirwa DT, Floyd S, Murphy C, Drobniewski FA, Fine PEMet al., 2004, DNA fingerprint changes in tuberculosis: Reinfection, evolution, or laboratory error?, JOURNAL OF INFECTIOUS DISEASES, Vol: 190, Pages: 1158-1166, ISSN: 0022-1899

Journal article

Baker LV, Brown T, Maiden MCJM, Drobniewski FAet al., 2004, Silent nucleotide polymorphisms and a phylogeny for Mycobacterium tuberculosis, Emerging Infectious Diseases, Vol: 10, Pages: 1568-1577, ISSN: 1080-6059

Much remains unknown of the phylogeny and evolution of Mycobacterium tuberculosis, an organism that kills 2 million people annually. Using a population-based approach that analyzes multiple loci around the chromosome, we demonstrate that neutral genetic variation in genes associated with antimicrobial drug resistance has sufficient variation to construct a robust phylogenetic tree for M. tuberculosis. The data describe a clonal population with a minimum of four distinct M. tuberculosis lineages, closely related to M. bovis. The lineages are strongly geographically associated. Nucleotide substitutions proven to cause drug resistance are distributed throughout the tree, whereas nonsynonymous base substitutions unrelated to drug resistance have a restricted distribution. The phylogenetic structure is concordant with all the previously described genotypic and phenotypic groupings of M. tuberculosis strains and provides a unifying framework for both epidemiologic and evolutionary analysis of M. tuberculosis populations.

Journal article

RA Atun, N Lennox-Chhugani, F Drobniewski, YA Samyshkin, RJ Cokeret al., 2004, A framework and toolkit for capturing the communicable disease programmes within health systems - Tuberculosis control as an illustrative example., European Journal of Public Health, Vol: 14, Pages: 267-273, ISSN: 1101-1262

Journal article

Balabanova Y, Fedorin I, Kuznetsov S, Graham C, Ruddy M, Atun R, Coker R, Drobniewski Fet al., 2004, Antimicrobial prescribing patterns for respiratory diseases including tuberculosis in Russia: a possible role in drug resistance?, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol: 54, Pages: 673-679, ISSN: 0305-7453

Journal article

Drobniewski F, Balabanova Y, Coker R, 2004, Clinical features, diagnosis, and management of multiple drug-resistant tuberculosis since 2002, CURRENT OPINION IN PULMONARY MEDICINE, Vol: 10, Pages: 211-217, ISSN: 1070-5287

Journal article

Ruddy MC, Davies AP, Yates MD, Yates S, Balasegaram S, Drabu Y, Patel B, Lozewicz S, Sen S, Bahl M, James E, Lipman M, Duckworth G, Watson JM, Piper M, Drobniewski FA, Maguire Het al., 2004, Outbreak of isoniazid resistant tuberculosis in north London, THORAX, Vol: 59, Pages: 279-285, ISSN: 0040-6376

Journal article

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