Imperial College London
Alternate

Professor Francis Drobniewski

Faculty of Medicine, Department of Infectious Disease

Chair in Global Health and Tuberculosis
 
 
 
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Contact

 

f.drobniewski

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Merker:2015:10.1038/ng.3195,
author = {Merker, M and Blin, C and Mona, S and Duforet-Frebourg, N and Lecher, S and Willery, E and Blum, MGB and Ruech-Gerdes, S and Mokrousov, I and Aleksic, E and Allix-Beguec, C and Antierens, A and Augustynowicz-Kopec, E and Banff', M and Barletta, F and Beckr, HP and Barry, CE and Bonnet, M and Borroni, E and Campos-Herrero, I and Cirillo, D and Cox, H and Crowe, S and Crudu, V and Die, R and Drobniewski, F and Fauville-Dufaux, M and Gagneuxr, S and Ghebremichael, S and Hanekom, M and Hoffner, S and Jiao, W-W and Kalon, S and Kohl, TA and Kontsevaya, I and Lillebaek, T and Maeda, S and Nikolayevskyy, V and Rasmussen, M and Rastogi, N and Samper, S and Sanchez-Padilla, E and Savic, B and Shamputa, IC and Shen, A and Sng, L-H and Stakenas, P and Toit, K and Varaine, F and Vukovic, D and Wahl, C and Warren, R and Supply, P and Niemann, S and Wirth, T},
doi = {10.1038/ng.3195},
journal = {Nature Genetics},
pages = {242--249},
title = {Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage},
url = {http://dx.doi.org/10.1038/ng.3195},
volume = {47},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.
AU  - Merker,M
AU  - Blin,C
AU  - Mona,S
AU  - Duforet-Frebourg,N
AU  - Lecher,S
AU  - Willery,E
AU  - Blum,MGB
AU  - Ruech-Gerdes,S
AU  - Mokrousov,I
AU  - Aleksic,E
AU  - Allix-Beguec,C
AU  - Antierens,A
AU  - Augustynowicz-Kopec,E
AU  - Banff',M
AU  - Barletta,F
AU  - Beckr,HP
AU  - Barry,CE
AU  - Bonnet,M
AU  - Borroni,E
AU  - Campos-Herrero,I
AU  - Cirillo,D
AU  - Cox,H
AU  - Crowe,S
AU  - Crudu,V
AU  - Die,R
AU  - Drobniewski,F
AU  - Fauville-Dufaux,M
AU  - Gagneuxr,S
AU  - Ghebremichael,S
AU  - Hanekom,M
AU  - Hoffner,S
AU  - Jiao,W-W
AU  - Kalon,S
AU  - Kohl,TA
AU  - Kontsevaya,I
AU  - Lillebaek,T
AU  - Maeda,S
AU  - Nikolayevskyy,V
AU  - Rasmussen,M
AU  - Rastogi,N
AU  - Samper,S
AU  - Sanchez-Padilla,E
AU  - Savic,B
AU  - Shamputa,IC
AU  - Shen,A
AU  - Sng,L-H
AU  - Stakenas,P
AU  - Toit,K
AU  - Varaine,F
AU  - Vukovic,D
AU  - Wahl,C
AU  - Warren,R
AU  - Supply,P
AU  - Niemann,S
AU  - Wirth,T
DO  - 10.1038/ng.3195
EP  - 249
PY  - 2015///
SN  - 1061-4036
SP  - 242
TI  - Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage
T2  - Nature Genetics
UR  - http://dx.doi.org/10.1038/ng.3195
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000350327900014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/ng.3195
VL  - 47
ER  -
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