Imperial College London
Alternate

Professor Francis Drobniewski

Faculty of Medicine, Department of Infectious Disease

Chair in Global Health and Tuberculosis
 
 
 
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Contact

 

f.drobniewski

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vella:2018:10.1016/j.tube.2017.10.006,
author = {Vella, V and Broda, A and Drobniewski, F},
doi = {10.1016/j.tube.2017.10.006},
journal = {Tuberculosis},
pages = {112--120},
title = {Should all suspected tuberculosis cases in high income countries be tested with GeneXpert?},
url = {http://dx.doi.org/10.1016/j.tube.2017.10.006},
volume = {110},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In countries with a low incidence of multidrug-resistant tuberculosis (MDR-TB), universal testing with GeneXpert might not be always cost-effective. This study provides hospital managers in low MDR-TB incidence countries with criteria on when decentralised universal GeneXpert testing would make sense. The alternatives taken into consideration include: universal microbiological culture and drug susceptibility testing (DST) only (comparator); as above but with concurrent centralized GeneXpert in a referral laboratory vs a decentralized GeneXpert system in every hospital to test smear-positive cases only; as above but testing all samples with GeneXpert regardless of smear status. The parameters were from the national TB statistics for England and from a systematic review. Decentralised GeneXpert to test any suspected TB case was the most cost-effective option when 6% or more TB patients belonged to the high-risk group, defined as previous TB diagnosis and or being born in countries with a high MDR-TB incidence. Hospital managers in England and other low MDR-TB incidence countries could use these findings to decide when to invest in GeneXpert or other molecular diagnostics with similar performance criteria for TB diagnostics.
AU  - Vella,V
AU  - Broda,A
AU  - Drobniewski,F
DO  - 10.1016/j.tube.2017.10.006
EP  - 120
PY  - 2018///
SN  - 1472-9792
SP  - 112
TI  - Should all suspected tuberculosis cases in high income countries be tested with GeneXpert?
T2  - Tuberculosis
UR  - http://dx.doi.org/10.1016/j.tube.2017.10.006
UR  - http://hdl.handle.net/10044/1/57219
VL  - 110
ER  -
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