Summary
Dr Fu Siong Ng is a Reader in Cardiac Electrophysiology at Imperial College London, and a Consultant Cardiologist at Imperial College Healthcare NHS Trust and Chelsea and Westminster Hospital NHS Foundation Trust. He is a Clinician Scientist and currently leads a British Heart Foundation-funded programme of research into arrhythmogenic mechanisms alongside performing invasive ablation procedures and implanting pacemakers and defibrillators in patients with heart rhythm disorders. Dr Ng is also the Programme Director for the intercalated BSc in Cardiovascular Sciences at Imperial College London, and is the Divisional Research Lead for the Division of Emergency & Integrated Care at Chelsea and Westminster Hospital NHS Foundation Trust. Dr Ng is Theme Lead (Theme 4: Remote Monitoring) for the current BHF Centre of Research Excellence at Imperial renewal bid (2024-2029).
Dr Ng studied Medicine at St. George’s, University of London, where he was awarded a First Class (Honours) BSc degree in Medical Sciences & Clinical Pharmacology and achieved Distinctions at his Final MBBS Examinations. He received his post-graduate clinical training in Cardiology and Cardiac Electrophysiology at Hammersmith and St. Mary’s Hospitals. Dr Ng was awarded his PhD by Imperial College London for his work on the effects of gap junction modulation on the post-infarct arrhythmic substrate, funded by an MRC Clinical Research Training Fellowship. He then conducted post-doctoral research at Washington University in Saint Louis, funded by a BHF Travel Fellowship, investigating the arrhythmogenic remodelling in heart failure by performing optical mapping experiments on explanted human hearts, before returning to Imperial.
Dr Ng is accredited as a Cardiac Electrophysiology Specialist with the European Heart Rhythm Association and is a Fellow of the European Society of Cardiology (FESC), Fellow of the Heart Rhythm Society (FHRS), Fellow of the Royal College of Physicians (FRCP) and Senior Fellow of the Higher Education Academy (SFHEA).
Dr Ng leads a multidisciplinary research group that consists of clinicians, biologists, engineers, physicists, and AI-scientists. He currently supervises 3 post-doctoral research associates and 8 PhD students at Imperial. He has >110 peer-reviewed publications and 2 patents, and currently holds a 5-year British Heart Foundation Programme Grant (2022-2027, £1.2M) as PI. Dr Ng's main research interests include:
- Developing AI-ECG algorithms for diagnosis and risk stratification
- Developing novel fibrillation mapping tools to classify patients into different AF electrophenotypes to tailor treatments
- Understanding the link between obesity and arrhythmias
- Reducing health inequalities through AI algorithms
- Understanding the role of inflammation in arrhythmias
- Understanding the electrophysiological remodelling in pulmonary hypertension
Dr Ng and his research group July 2023
Dr Ng and his research group December 2023
Selected Publications
Journal Articles
Handa B, Li X, Baxan N, et al., 2021, Ventricular fibrillation mechanism and global fibrillatory organisation are determined by gap junction coupling and fibrosis pattern, Cardiovascular Research, Vol:117, ISSN:0008-6363, Pages:1078-1090
Handa B, Li X, Aras KK, et al., 2020, Granger causality-based analysis for classification of fibrillation mechanisms and localisation of rotational drivers, Circulation: Arrhythmia and Electrophysiology, Vol:12, ISSN:1941-3084, Pages:258-273
Li X, Roney C, Handa B, et al., 2019, Standardised framework for quantitative analysisof fibrillation dynamics, Scientific Reports, Vol:9, ISSN:2045-2322
Leong KMW, Ng FS, yao C, et al., 2017, ST-Elevation Magnitude Correlates With Right Ventricular Outflow Tract Conduction Delay in Type I Brugada ECG, Circulation: Arrhythmia and Electrophysiology, Vol:10, ISSN:1941-3084
Roney CH, Cantwell CD, Bayer JD, et al., 2017, Spatial resolution requirements for accurate identification of drivers of atrial fibrillation, Circulation-arrhythmia and Electrophysiology, Vol:10, ISSN:1941-3084, Pages:1-13
Ng FS, Kalindjian JM, Cooper SA, et al., 2016, Enhancement of Gap Junction Function During Acute Myocardial Infarction Modifies Healing and Reduces Late Ventricular Arrhythmia Susceptibility, Jacc. Clinical Electrophysiology, Vol:2, ISSN:2405-5018, Pages:574-582
Ng FS, Holzem KM, Koppel AC, et al., 2014, Adverse Remodeling of the Electrophysiological Response to Ischemia-Reperfusion in Human Heart Failure Is Associated With Remodeling of Metabolic Gene Expression, Circulation-Arrhythmia and Electrophysiology, Vol:7, ISSN:1941-3149, Pages:875-U234
Rutledge CA, Ng FS, Sulkin MS, et al., 2014, c-Src kinase inhibition reduces arrhythmia inducibility and connexin43 dysregulation after myocardial infarction, Journal of the American College of Cardiology, Vol:63, ISSN:0735-1097, Pages:928-934
Ng FS, Shadi IT, Peters NS, et al., 2013, Selective heart rate reduction with ivabradine slows ischaemia-induced electrophysiological changes and reduces ischaemia-reperfusion-induced ventricular arrhythmias, Journal of Molecular and Cellular Cardiology, Vol:59, ISSN:0022-2828, Pages:67-75
Laughner JI, Ng FS, Sulkin MS, et al., 2012, Processing and analysis of cardiac optical mapping data obtained with potentiometric dyes, American Journal of Physiology - Heart and Circulatory Physiology, Vol:303, ISSN:0363-6135, Pages:H753-H765