Imperial College London
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Dr Fu Siong Ng

Faculty of Medicine, National Heart & Lung Institute

Reader in Cardiac Electrophysiology
 
 
 
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Contact

 

+44 (0)20 7594 3614f.ng Website

 
 
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Location

 

430ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Qureshi:2019:10.1016/j.hrthm.2019.05.032,
author = {Qureshi, N and Kim, S and Cantwell, C and Afonso, V and Bai, WJ and Ali, R and Shun-Shin, M and Louisa, M-L and Luther, V and Leong, K and Lim, E and Wright, I and Nagy, S and Hayat, S and Ng, FS and Koa-Wing, M and Linton, N and Lefroy, D and Whinnett, Z and Davies, DW and Kanagaratnam, P and Peters, N and Lim, PB},
doi = {10.1016/j.hrthm.2019.05.032},
journal = {Heart Rhythm},
pages = {1357--1367},
title = {Voltage during atrial fibrillation is superior to voltage during sinus rhythm in localizing areas of delayed enhancement on magnetic resonance imaging: An assessment of the posterior left atrium in patients with persistent atrial fibrillation},
url = {http://dx.doi.org/10.1016/j.hrthm.2019.05.032},
volume = {16},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundBipolar electrogram voltage during sinus rhythm (VSR) has been used as a surrogate for atrial fibrosis in guiding catheter ablation of persistent AF, but the fixed rate and wavefront characteristics present during sinus rhythm may not accurately reflect underlying functional vulnerabilities responsible for AF maintenance.ObjectivesWe hypothesized that given adequate temporal sampling, the spatial distribution of mean AF voltage (VmAF) should better correlate with delayed-enhancement MRI (MRI-DE) detected atrial fibrosis than VSR.MethodsAF was mapped (8s) during index ablation for persistent AF (20 patients) using a 20-pole catheter (660±28 points/map). Following cardioversion, VSR was mapped (557±326 points/map). Electroanatomic and MRI-DE maps were co-registered in 14 patients.Results(i) The time course of VmAF was assessed from 1-40 AF-cycles (∼8s) at 1113 locations. VmAF stabilized with sampling >4s (mean voltage error=0.05mV). (ii) Paired point analysis of VmAF from segments acquired 30s apart (3,667-sites, 15-patients), showed strong correlation (r=0.95, p<0.001). (iii) Delayed-enhancement (DE) was assessed across the posterior left atrial (LA) wall, occupying 33±13%. VmAF distributions (median[IQR]) were 0.21[0.14-0.35]mV in DE vs. 0.52[0.34-0.77]mV in Non-DE regions. VSR distributions were 1.34[0.65-2.48]mV in DE vs. 2.37[1.27-3.97]mV in Non-DE. A VmAF threshold of 0.35mV yielded sensitivity/specificity 75%/79% in detecting MRI-DE, compared with 63%/67% for VSR (1.8mV threshold).ConclusionThe correlation between low-voltage and posterior LA MRI-DE is significantly improved when acquired during AF vs. sinus rhythm. With adequate sampling, mean AF voltage is a reproducible marker reflecting the functional response to the underlying persistent AF substrate.
AU  - Qureshi,N
AU  - Kim,S
AU  - Cantwell,C
AU  - Afonso,V
AU  - Bai,WJ
AU  - Ali,R
AU  - Shun-Shin,M
AU  - Louisa,M-L
AU  - Luther,V
AU  - Leong,K
AU  - Lim,E
AU  - Wright,I
AU  - Nagy,S
AU  - Hayat,S
AU  - Ng,FS
AU  - Koa-Wing,M
AU  - Linton,N
AU  - Lefroy,D
AU  - Whinnett,Z
AU  - Davies,DW
AU  - Kanagaratnam,P
AU  - Peters,N
AU  - Lim,PB
DO  - 10.1016/j.hrthm.2019.05.032
EP  - 1367
PY  - 2019///
SN  - 1547-5271
SP  - 1357
TI  - Voltage during atrial fibrillation is superior to voltage during sinus rhythm in localizing areas of delayed enhancement on magnetic resonance imaging: An assessment of the posterior left atrium in patients with persistent atrial fibrillation
T2  - Heart Rhythm
UR  - http://dx.doi.org/10.1016/j.hrthm.2019.05.032
UR  - http://hdl.handle.net/10044/1/70699
VL  - 16
ER  -
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