Imperial College London

Dr Frédéric B. Piel

Faculty of MedicineSchool of Public Health

Senior Lecturer



+44 (0)20 7594 3346f.piel




Praed StreetSt Mary's Campus






BibTex format

author = {Hockham, C and Ekwattanakit, S and Bhatt, S and Penman, BS and Gupta, S and Viprakasit, V and Piel, FB},
doi = {10.1101/412718},
publisher = {Cold Spring Harbor Laboratory},
title = {Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia},
type = {Software},
url = {},
year = {2018}

RIS format (EndNote, RefMan)

AB - <jats:title>Abstract</jats:title><jats:p>Severe forms of α-thalassaemia, haemoglobin H disease and haemoglobin Bart’s hydrops fetalis, are an important public health concern in Southeast Asia. Yet information on the prevalence, genetic diversity and health burden of α-thalassaemia in the region remains limited. We compiled a geodatabase of α-thalassaemia prevalence and genetic diversity surveys and, using geostatistical modelling methods, generated the first continuous maps of α-thalassaemia mutations in Thailand and sub-national estimates of the number of newborns with severe forms in 2020. We also summarised the current evidence-base for α-thalassaemia prevalence and diversity for the region. We estimate that 3,595 (95% credible interval 1,717 – 6,199) newborns will be born with severe α-thalassaemia in Thailand in 2020, which is considerably higher than previous estimates. Accurate, fine-scale epidemiological data are necessary to guide sustainable national and regional health policies for α-thalassaemia control. Our maps and newborn estimates are an important first step towards this aim.</jats:p><jats:sec><jats:title>Funding</jats:title><jats:p>This work was supported by European Union’s Seventh Framework Programme (FP7//2007-2013)/European Research Council [268904 – DIVERSITY]</jats:p></jats:sec>
AU - Hockham,C
AU - Ekwattanakit,S
AU - Bhatt,S
AU - Penman,BS
AU - Gupta,S
AU - Viprakasit,V
AU - Piel,FB
DO - 10.1101/412718
PB - Cold Spring Harbor Laboratory
PY - 2018///
TI - Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia
UR -
ER -