Imperial College London

Dr Frédéric B. Piel

Faculty of MedicineSchool of Public Health

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3346f.piel

 
 
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Location

 

Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hockham:2019:10.7554/eLife.40580,
author = {Hockham, C and Gupta, S and Penman, B and Bhatt, S and Piel, F},
doi = {10.7554/eLife.40580},
journal = {eLife},
title = {Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia},
url = {http://dx.doi.org/10.7554/eLife.40580},
volume = {8},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Severe forms of α-thalassaemia, haemoglobin H disease and haemoglobin Bart’s hydrops fetalis, are an important public health concern in Southeast Asia. Yet information on the prevalence, genetic diversity and health burden of α-thalassaemia in the region remains limited. We compiled a geodatabase of α-thalassaemia prevalence and genetic diversity surveys and, using geostatistical modelling methods, generated the first continuous maps of α-thalassaemia mutations in Thailand and sub-national estimates of the number of newborns with severe forms in 2020. We also summarised the current evidence-base for α-thalassaemia prevalence and diversity for the region. We estimate that 3595 (95% credible interval 1,717–6,199) newborns will be born with severe α-thalassaemia in Thailand in 2020, which is considerably higher than previous estimates. Accurate, fine-scale epidemiological data are necessary to guide sustainable national and regional health policies for α-thalassaemia management. Our maps and newborn estimates are an important first step towards this aim.
AU - Hockham,C
AU - Gupta,S
AU - Penman,B
AU - Bhatt,S
AU - Piel,F
DO - 10.7554/eLife.40580
PY - 2019///
SN - 2050-084X
TI - Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia
T2 - eLife
UR - http://dx.doi.org/10.7554/eLife.40580
UR - http://hdl.handle.net/10044/1/70410
VL - 8
ER -