Imperial College London

Dr Frédéric B. Piel

Faculty of MedicineSchool of Public Health

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3346f.piel

 
 
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Location

 

Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Premawardhena:2016:10.1111/bjh.14437,
author = {Premawardhena, A and Allen, A and Piel, FBJ and Fisher, C and Perera, L and Rodrigo, R and Goonathilaka, G and Ramees, L and Peto, T and Olivieri, N and Weatherall, DJ},
doi = {10.1111/bjh.14437},
journal = {British Journal of Haematology},
pages = {475--484},
title = {The evolutionary and clinical implilcations of the uneven distribution of the frequency of the inherited haemoglobin variants over short geographical distances},
url = {http://dx.doi.org/10.1111/bjh.14437},
volume = {176},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Studies of the frequency of heterozygous carriers for common inheriteddiseases of haemoglobin in over 7500 adolescent children in 25 districts inSri Lanka have disclosed a highly significant variation over very short geo-graphical distances. A further analysis of these findings, including theirrelationship to the past frequency and distribution of malaria, climatic vari-ation, altitude, ethnic origin and consanguinity rates, have provided evi-dence regarding the evolutionary basis for the variable distribution of theseconditions over short distances. It is likely that the complex interplaybetween malaria and the environment, together with related ethnic andsocial issues, exists in many countries across the tropical belt. Hence, theseobservations emphasise the importance of micromapping heterozygote dis-tributions in high-frequency countries in order to define their true burdenand the facilities required for the prevention and management of thehomozygous and compound heterozygous disorders that result from theirinteraction.
AU - Premawardhena,A
AU - Allen,A
AU - Piel,FBJ
AU - Fisher,C
AU - Perera,L
AU - Rodrigo,R
AU - Goonathilaka,G
AU - Ramees,L
AU - Peto,T
AU - Olivieri,N
AU - Weatherall,DJ
DO - 10.1111/bjh.14437
EP - 484
PY - 2016///
SN - 1365-2141
SP - 475
TI - The evolutionary and clinical implilcations of the uneven distribution of the frequency of the inherited haemoglobin variants over short geographical distances
T2 - British Journal of Haematology
UR - http://dx.doi.org/10.1111/bjh.14437
UR - http://hdl.handle.net/10044/1/43029
VL - 176
ER -