Research work in the Baldwin lab focuses on the development of synthetic biology approaches to facilitate the engineering of new biological systems for real-world applications. To this end we have developed foundational tools, like our BASIC DNA assembly method, that transform our ability to rapidly prototype new biological designs. We are also developing enhanced methods for accurate metrology to better understand and model the relationship between input design and phenotypic response. These fundamental developments are being applied across a broad range of projects that address gene circuit design; RNA feedback control; in vivo directed evolution for the generation of new protein specificity and functionality; engineering protein nanocages as vectors for targeted drug delivery.
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et al., 2015, BASIC: a new Biopart Assembly Standard for Idempotent Cloning provides accurate, single-tier DNA assembly for synthetic biology, Acs Synthetic Biology, Vol:4, ISSN:2161-5063, Pages:781-787
et al., 2015, Bricks and blueprints: methods and standards for DNA assembly, Nature Reviews Molecular Cell Biology, Vol:16, ISSN:1471-0080, Pages:568-576