Imperial College London

DrGraemeBirdsey

Faculty of MedicineNational Heart & Lung Institute

Senior Lecturer in Vascular Science
 
 
 
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Contact

 

+44 (0)20 7594 8633g.birdsey Website

 
 
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Location

 

535ICTEM buildingHammersmith Campus

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Summary

 

Summary

Dr Birdsey's research focuses on the transcriptional and epigenetic regulation of endothelial cell gene expression during angiogenesis and lymphangiogenesis.

Dr Birdsey joined the National Heart and Lung Institute, Imperial College London, in 2004 as a Postdoctoral Research Associate in the group of Prof Anna Randi, before being promoted to Research Fellow in 2010. He was appointed to the position of Lecturer in Vascular Sciences in 2013 and Senior Lecturer in 2020.

BIOSKETCH

In 1994 Graeme Birdsey graduated with a BSc in Applied Biochemistry from Liverpool John Moores University and he then went on to obtain a PhD in Molecular Cell Biology from University College London. Dr Birdsey’s PhD thesis and postdoctoral research project in Prof Chris Danpure’s lab at UCL focused on the molecular evolution of the intracellular targeting of the metabolic enzyme alanine:glyoxylate aminotransferase, AGT.

Dr Birdsey continued his scientific training with a two-year postdoctoral position with Dr James Leiper in Prof Patrick Vallance’s group at UCL. The work focused on the regulation of nitric oxide (NO) synthesis by endogenously produced competitive inhibitors (asymmetric methylarginines) of NO synthase enzymes. These molecules have been the subject of considerable interest as elevated levels have been reported in numerous disease states including hypertension, heart failure, renal failure, atherosclerosis, pre-eclampsia and type 2 diabetes. 


  Endothelial cell stained with markers to the adhesion molecule vinculin (red) and the actin cytoskeleton (green)

Endothelial cell stained with markers to the adhesion molecule vinculin (red) and the actin cytoskeleton (green)

 

  Dividing endothelial cell. Acetylated microtubules in green and DNA/chromatinshown in purple.

Dividing endothelial cell. Acetylated microtubules in green and DNA/chromatinshown in purple.

Selected Publications

Journal Articles

Peghaire C, Dufton N, Lang M, et al., 2019, The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature, Nature Communications, Vol:10, ISSN:2041-1723

Kalna V, Yang Y, Peghaire C, et al., 2019, The transcription factor ERG regulates super-enhancers associated with an endothelial-specific gene expression program, Circulation Research, Vol:124, ISSN:0009-7330, Pages:1337-1349

Dufton NP, peghaire CR, Osuna-Almagro L, et al., 2017, Dynamic regulation of canonical TGFβ signaling by endothelial transcription factor ERG protects from liver fibrogenesis, Nature Communications, Vol:8, ISSN:2041-1723

Shah AV, Birdsey GM, Peghaire C, et al., 2017, The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability, Nature Communications, Vol:8, ISSN:2041-1723

Shah AV, Birdsey GM, Randi AM, 2016, Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG, Vascular Pharmacology, Vol:86, ISSN:1879-3649, Pages:3-13

Birdsey GM, Shah AV, Dufton N, et al., 2015, The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling., Developmental Cell, Vol:32, ISSN:1534-5807, Pages:82-96

Birdsey GM, Dryden NH, Shah AV, et al., 2012, The transcription factor Erg regulates expression of histone deacetylase 6 and multiple pathways involved in endothelial cell migration and angiogenesis, Blood, Vol:119, ISSN:0006-4971, Pages:894-903

Birdsey GM, Dryden NH, Amsellem V, et al., 2008, Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin, Blood, Vol:111, ISSN:0006-4971, Pages:3498-3506

More Publications