Imperial College London

DrGraemeBirdsey

Faculty of MedicineNational Heart & Lung Institute

Lecturer in Vascular Sciences
 
 
 
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Contact

 

+44 (0)20 7594 8633g.birdsey Website

 
 
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Location

 

525W5ICTEM buildingHammersmith Campus

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Summary

 

Summary

In 1994 Graeme Birdsey graduated with a BSc in Applied Biochemistry from Liverpool John Moores University and he then went on to obtain a PhD in Molecular Cell Biology from University College London. Dr Birdsey’s PhD thesis and postdoctoral research project in Prof Chris Danpure’s lab at UCL focused on the molecular evolution of the intracellular targeting of the metabolic enzyme alanine:glyoxylate aminotransferase, AGT.

Dr Birdsey continued his scientific training with a two-year postdoctoral position with Dr James Leiper in Prof Patrick Vallance’s group at UCL. The work focused on the regulation of nitric oxide (NO) synthesis by endogenously produced competitive inhibitors (asymmetric methylarginines) of NO synthase enzymes. These molecules have been the subject of considerable interest as elevated levels have been reported in numerous disease states including hypertension, heart failure, renal failure, atherosclerosis, pre-eclampsia and type 2 diabetes. 

In 2004, Dr Birdsey moved to NHLI Cardiovascular Sciences at Imperial College as a Research Fellow in the laboratory of Prof Anna Randi. Currently, he is a Lecturer in Vascular Sciences within the National Heart & Lung Institute, Imperial Centre for Translational and Experimental Medicine.

  Endothelial cell stained with markers to the adhesion molecule vinculin (red) and the actin cytoskeleton (green)

Endothelial cell stained with markers to the adhesion molecule vinculin (red) and the actin cytoskeleton (green)

 

  Dividing endothelial cell. Acetylated microtubules in green and DNA/chromatinshown in purple.

Dividing endothelial cell. Acetylated microtubules in green and DNA/chromatinshown in purple.

Selected Publications

Journal Articles

Shah AV, Birdsey GM, Peghaire C, et al., 2017, The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability, Nature Communications, Vol:8, ISSN:2041-1723

Shah AV, Birdsey GM, Randi AM, 2016, Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG, Vascular Pharmacology, Vol:86, ISSN:1537-1891, Pages:3-13

Birdsey GM, Shah AV, Randi AM, 2015, Regulation of vascular development and angiogenesis by the ETS transcription factor ERG, Acta Physiologica, Vol:215, ISSN:1748-1708, Pages:19-19

Birdsey GM, Shah AV, Dufton N, et al., 2015, The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling., Developmental Cell, Vol:32, ISSN:1534-5807, Pages:82-96

More Publications