Imperial College London

ProfessorGadFrankel

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Molecular Pathogenesis
 
 
 
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Contact

 

+44 (0)20 7594 5253g.frankel

 
 
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Location

 

1.46Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

224 results found

Ooka T, Vieira MAM, Ogura Y, Beutin L, La Ragione R, van Diemen PM, Stevens MP, Aktan I, Cawthraw S, Best A, Hernandes RT, Krause G, Gomes TAT, Hayashi T, Frankel Get al., 2007, Characterization of tccP2 carried by atypical enteropathogenic Escherichia coli, FEMS MICROBIOLOGY LETTERS, Vol: 271, Pages: 126-135, ISSN: 0378-1097

JOURNAL ARTICLE

Schuller S, Chong Y, Lewin J, Kenny B, Frankel G, Phillips ADet al., 2007, Tir phosphorylation and Nck/N-WASP recruitment by enteropathogenic and enterohaemorrhagic Escherichia coli during ex vivo colonization of human intestinal mucosa is different to cell culture models, CELLULAR MICROBIOLOGY, Vol: 9, Pages: 1352-1364, ISSN: 1462-5814

JOURNAL ARTICLE

Whale AD, Hernandes RT, Ooka T, Beutin L, Schuller S, Garmendia J, Crowther L, Vieira MAM, Ogura Y, Krause G, Illips ADP, Gomes TAT, Hayashi T, Frankel Get al., 2007, TccP2-mediated subversion of actin dynamics by EPEC 2 - a distinct evolutionary lineage of enteropathogenic Escherichia coli, MICROBIOLOGY-SGM, Vol: 153, Pages: 1743-1755, ISSN: 1350-0872

JOURNAL ARTICLE

Wiles S, Crepin VF, Childs G, Frankel G, Kerton Aet al., 2007, Use of biophotonic imaging as a training aid for administration of substances in laboratory rodents, LABORATORY ANIMALS, Vol: 41, Pages: 321-328, ISSN: 0023-6772

JOURNAL ARTICLE

van Diemen PM, Dziva F, Abu-Median A, Wallis TS, van den Bosch H, Dougan G, Chanter N, Frankel G, Stevens MPet al., 2007, Subunit vaccines based on intimin and Efa-1 polypeptides induce humoral immunity in cattle but do not protect against intestinal colonisation by enterohaemorrhagic Escherichia coli O157 : H7 or O26 : H-, VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol: 116, Pages: 47-58, ISSN: 0165-2427

JOURNAL ARTICLE

Caron E, Crepini VF, Simpson N, Knutton S, Garmendia J, Frankel Get al., 2006, Subversion of actin dynamics by EPEC and EHEC, CURRENT OPINION IN MICROBIOLOGY, Vol: 9, Pages: 40-45, ISSN: 1369-5274

JOURNAL ARTICLE

Fitzhenry R, Dahan S, Torres AG, Chong Y, Heuschkel R, Murch SH, Thomson M, Kaper JB, Frankel G, Phillips ADet al., 2006, Long polar fimbriae and tissue tropism in Escherichia coli O157 : H7, MICROBES AND INFECTION, Vol: 8, Pages: 1741-1749, ISSN: 1286-4579

JOURNAL ARTICLE

Garmendia J, Carlier M-F, Egile C, Didry D, Frankel Get al., 2006, Characterization of TccP-mediated N-WASP activation during enterohaemorrhagic Escherichia coli infection, CELLULAR MICROBIOLOGY, Vol: 8, Pages: 1444-1455, ISSN: 1462-5814

JOURNAL ARTICLE

Kelly M, Hart E, Mundy R, Marches O, Wiles S, Badea L, Luck S, Tauschek M, Frankel G, Robins-Browne RM, Hartland ELet al., 2006, Essential role of the type III secretion system effector NleB in colonization of mice by Citrobacter rodentium, INFECTION AND IMMUNITY, Vol: 74, Pages: 2328-2337, ISSN: 0019-9567

JOURNAL ARTICLE

Malfitano AM, Cahill R, Mitchell P, Frankel G, Dougan G, Bifulco M, Lombardi G, Lechler RI, Bamford KBet al., 2006, Helicobacter pylori has stimulatory effects on naive T cells, HELICOBACTER, Vol: 11, Pages: 21-30, ISSN: 1083-4389

JOURNAL ARTICLE

Marches O, Batchelor M, Shaw RK, Patel A, Cummings N, Nagai T, Sasakawa C, Carlsson SR, Lundmark R, Cougoule C, Caron E, Knutton S, Connerton I, Frankel Get al., 2006, EspF of enteropathogenic Escherichia coli binds sorting nexin 9, JOURNAL OF BACTERIOLOGY, Vol: 188, Pages: 3110-3115, ISSN: 0021-9193

JOURNAL ARTICLE

Mundy R, Girard F, FitzGerald AJ, Frankel Get al., 2006, Comparison of colonization dynamics and pathology of mice infected with enteropathogenic Escherichia coli, enterohaemorrhagic E-coli and Citrobacter rodentium, FEMS MICROBIOLOGY LETTERS, Vol: 265, Pages: 126-132, ISSN: 0378-1097

JOURNAL ARTICLE

Patel A, Cummings N, Batchelor M, Hill PJ, Dubois T, Mellits KH, Frankel G, Connerton Iet al., 2006, Host protein interactions with enteropathogenic Escherichia coli (EPEC): 14-3-3 tau binds Tir and has a role in EPEC-induced actin polymerization, CELLULAR MICROBIOLOGY, Vol: 8, Pages: 55-71, ISSN: 1462-5814

JOURNAL ARTICLE

Simpson N, Shaw R, Crepin VF, Mundy R, FitzGerald AJ, Cummings N, Straatman-Iwanowska A, Connerton I, Knutton S, Frankel Get al., 2006, The enteropathogenic Escherichia coli type III secretion system effector Map binds EBP50/NHERF1: implication for cell signalling and diarrhoea, MOLECULAR MICROBIOLOGY, Vol: 60, Pages: 349-363, ISSN: 0950-382X

JOURNAL ARTICLE

Smollett K, Shaw RK, Garmendia J, Knutton S, Frankel Get al., 2006, Function and distribution of EspG2, a type III secretion system effector of enteropathogenic Escherichia coli., Microbes Infect, Vol: 8, Pages: 2220-2227, ISSN: 1286-4579

The enteropathogenic Escherichia coli (EPEC) effector protein EspG, like the Shigella effector VirA, functions through disruption of the host cell microtubule network. Reports have differed as to whether the EspG homologue, EspG2, is also responsible for microtubule disruption. In this study we show that following translocation, EspG2 and VirA are localised under adherent bacteria and able to restore the microtubule disruption phenotype to an espG/espG2 double EPEC mutant. The espG/espG2 double mutant produced A/E lesions similar to wild-type EPEC on human intestinal in vitro organ cultures. Determining the distribution of espG and espG2 among clinical EPEC isolates revealed two different types of espG (espG alpha and espG beta) and espG2 (intact and pseudo genes), which were associated with specific EPEC serotypes and closely followed the EPEC lineage. This investigation has established a role for EspG2 in the disruption of the microtubule network and associated different espG and espG2 types with different groups of EPEC.

JOURNAL ARTICLE

Tatsuno I, Mundy R, Frankel G, Chong YW, Phillips AD, Torres AG, Kaper JBet al., 2006, The lpf gene cluster for long polar fimbriae is not involved in adherence of enteropathogenic Escherichia coli or virulence of Citrobacter rodentium, INFECTION AND IMMUNITY, Vol: 74, Pages: 265-272, ISSN: 0019-9567

JOURNAL ARTICLE

Tobe T, Beatson SA, Taniguchi H, Abe H, Bailey CM, Fivian A, Younis R, Matthews S, Marches O, Frankel G, Hayashi T, Pallen MJet al., 2006, An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 103, Pages: 14941-14946, ISSN: 0027-8424

JOURNAL ARTICLE

Vlisidou I, Dziva F, La Ragione RM, Best A, Garmendia J, Hawes P, Monaghan P, Cawthraw SA, Frankel G, Woodward MJ, Stevens MPet al., 2006, Role of intimin-Tir interactions and the Tir-cytoskeleton coupling protein in the colonization of calves and lambs by Escherichia coli O157 : H7, INFECTION AND IMMUNITY, Vol: 74, Pages: 758-764, ISSN: 0019-9567

JOURNAL ARTICLE

Vlisidou I, Marches O, Dziva F, Mundy R, Frankel G, Stevens MPet al., 2006, Identification and characterization of EspK, a type III secreted effector protein of enterohaemorrhagic Escherichia coli O157 : H7, FEMS MICROBIOLOGY LETTERS, Vol: 263, Pages: 32-40, ISSN: 0378-1097

JOURNAL ARTICLE

Whale AD, Garmendia J, Gomes TA, Frankel Get al., 2006, A novel category of enteropathogenic Escherichia coli simultaneously utilizes the Nck and TccP pathways to induce actin remodelling, CELLULAR MICROBIOLOGY, Vol: 8, Pages: 999-1008, ISSN: 1462-5814

JOURNAL ARTICLE

Wiles S, Hanage WP, Frankel G, Robertson Bet al., 2006, Modelling infectious disease - time to think outside the box?, NATURE REVIEWS MICROBIOLOGY, Vol: 4, Pages: 307-312, ISSN: 1740-1526

JOURNAL ARTICLE

Wiles S, Pickard KM, Peng K, MacDonald TT, Frankel Get al., 2006, In vivo bioluminescence imaging of the murine pathogen Citrobacter rodentium, INFECTION AND IMMUNITY, Vol: 74, Pages: 5391-5396, ISSN: 0019-9567

JOURNAL ARTICLE

Chen HD, Frankel G, 2005, Enteropathogenic Escherichia coli: unravelling pathogenesis, FEMS MICROBIOLOGY REVIEWS, Vol: 29, Pages: 83-98, ISSN: 0168-6445

JOURNAL ARTICLE

Crepin VF, Prasannan S, Shaw RK, Wilson RK, Creasey E, Abe CM, Knutton S, Frankel G, Matthews Set al., 2005, Structural and functional studies of the enteropathogenic Escherichia coli type III needle complex protein EscJ, MOLECULAR MICROBIOLOGY, Vol: 55, Pages: 1658-1670, ISSN: 0950-382X

JOURNAL ARTICLE

Crepin VF, Shaw R, Abe CM, Knutton S, Frankel Get al., 2005, Polarity of enteropathogenic Escherichia coli EspA filament assembly and protein secretion, JOURNAL OF BACTERIOLOGY, Vol: 187, Pages: 2881-2889, ISSN: 0021-9193

JOURNAL ARTICLE

Crepin VF, Shaw R, Knutton S, Frankel Get al., 2005, Molecular basis of antigenic polymorphism of EspA filaments: Development of a peptide display technology, JOURNAL OF MOLECULAR BIOLOGY, Vol: 350, Pages: 42-52, ISSN: 0022-2836

JOURNAL ARTICLE

Dahan S, Wiles S, La Ragione RM, Best A, Woodward MJ, Stevens MP, Shaw RK, Chong YW, Knutton S, Phillips A, Frankel Get al., 2005, EspJ is a prophage-carried type III effector protein of attaching and effacing pathogens that modulates infection dynamics, INFECTION AND IMMUNITY, Vol: 73, Pages: 679-686, ISSN: 0019-9567

JOURNAL ARTICLE

Delahay RM, Knutton S, Shaw RK, Hartland EL, Pallen MJ, Frankel Get al., 2005, The coiled-coil domain of EspA is essential for the assembly of the type III secretion translocon on the surface of enteropathogenic Escherichia coli (vol 274, pg 35969, 1999), JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 280, Pages: 19436-19436, ISSN: 0021-9258

JOURNAL ARTICLE

Garmendia J, Frankel G, 2005, Operon structure and gene expression of the espJ-tccP locus of enterohaernorrhagic Escherichia coli O157 : H7, FEMS MICROBIOLOGY LETTERS, Vol: 247, Pages: 137-145, ISSN: 0378-1097

JOURNAL ARTICLE

Garmendia J, Frankel G, Crepin VF, 2005, Enteropathogenic and enterohemorrhagic Escherichia coli infections: Translocation, translocation, translocation, INFECTION AND IMMUNITY, Vol: 73, Pages: 2573-2585, ISSN: 0019-9567

JOURNAL ARTICLE

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