Imperial College London
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ProfessorGadFrankel

Faculty of Natural Sciences, Department of Life Sciences

Professor of Molecular Pathogenesis
 
 
 
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Contact

 

+44 (0)20 7594 5253g.frankel

 
 
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Location

 

1.46Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Connolly:2018:10.1038/s41467-018-06701-4,
author = {Connolly, JPR and Slater, SL and O'Boyle, N and Goldstone, RJ and Crepin, VF and Gallego, DR and Herzyk, P and Smith, DGE and Douce, GR and Frankel, G and Roe, AJ},
doi = {10.1038/s41467-018-06701-4},
journal = {Nature Communications},
title = {Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion},
url = {http://dx.doi.org/10.1038/s41467-018-06701-4},
volume = {9},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Niche-adaptation of a bacterial pathogen hinges on the ability to recognize the complexity of signals from the environment and integrate that information with the regulation of genes critical for infection. Here we report the transcriptome of the attaching and effacing pathogen Citrobacter rodentium during infection of its natural murine host. Pathogen gene expression in vivo was heavily biased towards the virulence factor repertoire and was found to be co-ordinated uniquely in response to the host. Concordantly, we identified the host-specific induction of a metabolic pathway that overlapped with the regulation of virulence. The essential type 3 secretion system and an associated suite of distinct effectors were found to be modulated co-ordinately through a unique mechanism involving metabolism of microbiota-derived 1,2-propanediol, which dictated the ability to colonize the host effectively. This study provides novel insights into how host-specific metabolic adaptation acts as a cue to fine-tune virulence.
AU  - Connolly,JPR
AU  - Slater,SL
AU  - O'Boyle,N
AU  - Goldstone,RJ
AU  - Crepin,VF
AU  - Gallego,DR
AU  - Herzyk,P
AU  - Smith,DGE
AU  - Douce,GR
AU  - Frankel,G
AU  - Roe,AJ
DO  - 10.1038/s41467-018-06701-4
PY  - 2018///
SN  - 2041-1723
TI  - Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-018-06701-4
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000446846600006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/64832
VL  - 9
ER  -
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