Imperial College London
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ProfessorGadFrankel

Faculty of Natural Sciences, Department of Life Sciences

Professor of Molecular Pathogenesis
 
 
 
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Contact

 

+44 (0)20 7594 5253g.frankel

 
 
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Location

 

1.46Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chatterjee:2021:10.1111/tra.12817,
author = {Chatterjee, S and Choi, A and Frankel, G},
doi = {10.1111/tra.12817},
journal = {Traffic},
pages = {412--424},
title = {A systematic review of Sec24 cargo interactome},
url = {http://dx.doi.org/10.1111/tra.12817},
volume = {22},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Endoplasmic reticulum (ER)-to-Golgi trafficking is an essential and highly conserved cellular process. The coat protein complex-II (COPII) arm of the trafficking machinery incorporates a wide array of cargo proteins into vesicles through direct or indirect interactions with Sec24, the principal subunit of the COPII coat. Approximately one-third of all mammalian proteins rely on the COPII mediated secretory pathway for membrane insertion or secretion. There are four mammalian Sec24 paralogs and three yeast Sec24 paralogs with emerging evidence of paralog-specific cargo interaction motifs. Furthermore, individual paralogs also differ in their affinity for a subset of sorting motifs present on cargo proteins. As with many aspects of protein trafficking, we lack a systematic and thorough understanding of the interaction of Sec24 with cargoes. This systematic review focuses on the current knowledge of cargo binding to both yeast and mammalian Sec24 paralogs and their ER export motifs. The analyses show that Sec24 paralog specificity of cargo (and cargo receptors) range from exclusive paralog dependence or preference to partial redundancy. Wealso discuss how the Sec24 secretion system is hijacked by viral (e.g., VSV-G, Hepatitis B envelope protein) and bacterial (e.g., the enteropathogenic E. coli type III secretion system effector NleA/EspI) pathogens.
AU  - Chatterjee,S
AU  - Choi,A
AU  - Frankel,G
DO  - 10.1111/tra.12817
EP  - 424
PY  - 2021///
SN  - 1398-9219
SP  - 412
TI  - A systematic review of Sec24 cargo interactome
T2  - Traffic
UR  - http://dx.doi.org/10.1111/tra.12817
UR  - https://onlinelibrary.wiley.com/doi/10.1111/tra.12817
UR  - http://hdl.handle.net/10044/1/92209
VL  - 22
ER  -
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