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@article{Petty:2009:10.1128/JB.01144-09,
author = {Petty, NK and Bulgin, R and Crepin, VF and Cerdeno-Tarraga, AM and Schroeder, GN and Quail, MA and Lennard, N and Corton, C and Barron, A and Clark, L and Toribio, AL and Parkhill, J and Dougan, G and Frankel, G and Thomson, NR},
doi = {10.1128/JB.01144-09},
journal = {Journal of Bacteriology},
pages = {525--538},
title = {The Citrobacter rodentium Genome Sequence Reveals Convergent Evolution with Human Pathogenic Escherichia coli},
url = {http://dx.doi.org/10.1128/JB.01144-09},
volume = {192},
year = {2009}
}

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TY  - JOUR
AB  - Citrobacter rodentium (formally Citrobacter freundii biotype 4280) is a highly infectious pathogen that causes colitis and transmissible colonic hyperplasia in mice. In common with enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC, respectively), C. rodentium exploits a type III secretion system (T3SS) to induce attaching and effacing (A/E) lesions that are essential for virulence. Here, we report the fully annotated genome sequence of the 5.3-Mb chromosome and four plasmids harbored by C. rodentium strain ICC168. The genome sequence revealed key information about the phylogeny of C. rodentium and identified 1,585 C. rodentium-specific (without orthologues in EPEC or EHEC) coding sequences, 10 prophage-like regions, and 17 genomic islands, including the locus for enterocyte effacement (LEE) region, which encodes a T3SS and effector proteins. Among the 29 T3SS effectors found in C. rodentium are all 22 of the core effectors of EPEC strain E2348/69. In addition, we identified a novel C. rodentium effector, named EspS. C. rodentium harbors two type VI secretion systems (T6SS) (CTS1 and CTS2), while EHEC contains only one T6SS (EHS). Our analysis suggests that C. rodentium and EPEC/EHEC have converged on a common host infection strategy through access to a common pool of mobile DNA and that C. rodentium has lost gene functions associated with a previous pathogenic niche.
AU  - Petty,NK
AU  - Bulgin,R
AU  - Crepin,VF
AU  - Cerdeno-Tarraga,AM
AU  - Schroeder,GN
AU  - Quail,MA
AU  - Lennard,N
AU  - Corton,C
AU  - Barron,A
AU  - Clark,L
AU  - Toribio,AL
AU  - Parkhill,J
AU  - Dougan,G
AU  - Frankel,G
AU  - Thomson,NR
DO  - 10.1128/JB.01144-09
EP  - 538
PY  - 2009///
SN  - 1098-5530
SP  - 525
TI  - The Citrobacter rodentium Genome Sequence Reveals Convergent Evolution with Human Pathogenic Escherichia coli
T2  - Journal of Bacteriology
UR  - http://dx.doi.org/10.1128/JB.01144-09
UR  - http://hdl.handle.net/10044/1/41829
VL  - 192
ER  -

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