Imperial College London
Portrait Picture

ProfessorGadFrankel

Faculty of Natural Sciences, Department of Life Sciences

Professor of Molecular Pathogenesis
 
 
 
//

Contact

 

+44 (0)20 7594 5253g.frankel

 
 
//

Location

 

1.46Flowers buildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Ale:2016:10.1128/IAI.00606-16,
author = {Ale, A and Crepin, VF and Collins and Constantinou, N and Habibzay and Babtie, AC and Frankel, G and Stumpf, MP},
doi = {10.1128/IAI.00606-16},
journal = {Infection and Immunity},
title = {Model of host-pathogen Interaction dynamics links In vivo optical imaging and immune responses},
url = {http://dx.doi.org/10.1128/IAI.00606-16},
volume = {85},
year = {2016}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Tracking disease progression in vivo is essential for the development of treatments against bacterial infection. Optical imaging has become a central tool for in vivo tracking of bacterial population development and therapeutic response. For a precise understanding of in vivo imaging results in terms of disease mechanisms derived from detailed postmortem observations, however, a link between the two is needed. Here, we develop a model that provides that link for the investigation of Citrobacter rodentium infection, a mouse model for enteropathogenic Escherichia coli (EPEC). We connect in vivo disease progression of C57BL/6 mice infected with bioluminescent bacteria, imaged using optical tomography and X-ray computed tomography, to postmortem measurements of colonic immune cell infiltration. We use the model to explore changes to both the host immune response and the bacteria and to evaluate the response to antibiotic treatment. The developed model serves as a novel tool for the identification and development of new therapeutic interventions.
AU  - Ale,A
AU  - Crepin,VF
AU  - Collins
AU  - Constantinou,N
AU  - Habibzay
AU  - Babtie,AC
AU  - Frankel,G
AU  - Stumpf,MP
DO  - 10.1128/IAI.00606-16
PY  - 2016///
SN  - 1098-5522
TI  - Model of host-pathogen Interaction dynamics links In vivo optical imaging and immune responses
T2  - Infection and Immunity
UR  - http://dx.doi.org/10.1128/IAI.00606-16
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27821583
UR  - http://hdl.handle.net/10044/1/44372
VL  - 85
ER  -
Download