Imperial College London
Portrait Picture

Professor Guido Franzoso

Faculty of Medicine, Department of Immunology and Inflammation

Chair in Inflammation and Signal Transduction
 
 
 
//

Contact

 

+44 (0)20 3313 8421g.franzoso Website

 
 
//

Assistant

 

Miss Anjli Jagpal +44 (0)20 3313 3152

 
//

Location

 

5N1Commonwealth BuildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Bennett:2018:10.1016/j.biocel.2017.12.020,
author = {Bennett, J and Capece, D and Begalli, F and Verzella, D and D'Andrea, D and Tornatore, L and Franzoso, G},
doi = {10.1016/j.biocel.2017.12.020},
journal = {Int J Biochem Cell Biol},
pages = {108--112},
title = {NF-κB in the crosshairs: Rethinking an old riddle.},
url = {http://dx.doi.org/10.1016/j.biocel.2017.12.020},
volume = {95},
year = {2018}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Constitutive NF-κB signalling has been implicated in the pathogenesis of most human malignancies and virtually all non-malignant pathologies. Accordingly, the NF-κB pathway has been aggressively pursued as an attractive therapeutic target for drug discovery. However, the severe on-target toxicities associated with systemic NF-κB inhibition have thus far precluded the development of a clinically useful, NF-κB-targeting medicine as a way to treat patients with either oncological or non-oncological diseases. This minireview discusses some of the more promising approaches currently being developed to circumvent the preclusive safety liabilities of global NF-κB blockade by selectively targeting pathogenic NF-κB signalling in cancer, while preserving the multiple physiological functions of NF-κB in host defence responses and tissue homeostasis.
AU  - Bennett,J
AU  - Capece,D
AU  - Begalli,F
AU  - Verzella,D
AU  - D'Andrea,D
AU  - Tornatore,L
AU  - Franzoso,G
DO  - 10.1016/j.biocel.2017.12.020
EP  - 112
PY  - 2018///
SP  - 108
TI  - NF-κB in the crosshairs: Rethinking an old riddle.
T2  - Int J Biochem Cell Biol
UR  - http://dx.doi.org/10.1016/j.biocel.2017.12.020
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29277662
UR  - http://hdl.handle.net/10044/1/55697
VL  - 95
ER  -
Download