Imperial College London


Faculty of MedicineDepartment of Medicine

Chair in Nutrition and Dietetics



+44 (0)20 3313 8037g.frost Website




Commonwealth BiuldingHammersmith HospitalHammersmith Campus





I qualified as a dietitian in 1982 and have always maintained a clinical input throughout my career.  Was appointed to Professor of Nutrition and Dietetics at Imperial College Jan 2008.  Prior to this, for 18 years Gary had work at Hammersmith Hospital.  Over his time at Hammersmith he gained his PhD in Nutrition and was appointed Honorary Reader in Nutrition at Imperial College, then joined the University of Surrey as Professor of Nutrition and Dietetics in 2005.  My research interests are very diverse and some are listed below:

Dietary Carbohydrates: Are a major focus of my work has been on the role of dietary carbohydrates on appetite regulation, insulin resistances and lipid metabolism in particular the glycaemic index as a model of the physiological effects of carbohydrates.  We were the first to demonstrate the impact of low glycaemic diets on adipocyte metabolism.  More recently in partnership with Professor Jimmy Bell we are using, MRI, MRS and fMRI to take an integrative physiological approach to investigating the role of dietary carbohydrates on body composition and appetite regulation.  Some of this work has been presented in abstract form and demonstrates for the first time central effects of fermentable carbohydrates on appetite centres in the hypothalamus.

Obesity Management:  Our work in the practical management of obesity has be sited widely including current management guidelines.  More recently we have demonstrated the efficacy of an intensive weight management system based on behavioural change on long term weight loss.  We have a major interest in understanding how nutrients and eating patterns effect.  The group is part of Investigative Medicine which is headed by Professor Bloom.  We have been part of the team that has demonstrated the importance of a number of gut petites in appetite regulation peptides in appetite regulation.  We also have an on going project investigating the role of nutrients in the secretion of appetite regulating peptides and a major interest in the basic nutritional physiology involved in energy balance.

Nutrition in the Elderly and hospitalized patient:  Over the last 10 years I have built up a reputation for undertaking clinical trials aimed at reducing the risk of malnutrition in this vulnerable group.  Our current interests include understanding changes in appetite regulation as we age.


Stradling C, Thomas GN, Hemming K, et al., 2016, Randomised controlled pilot study to assess the feasibility of a Mediterranean Portfolio dietary intervention for cardiovascular risk reduction in HIV dyslipidaemia: a study protocol, Bmj Open, Vol:6, ISSN:2044-6055

Guess ND, Dornhorst A, Oliver N, et al., 2016, A Randomised Crossover Trial: The Effect of Inulin on Glucose Homeostasis in Subtypes of Prediabetes, Annals of Nutrition and Metabolism, Vol:68, ISSN:0250-6807, Pages:26-34

Brown AC, Taheri S, Dornhorst A, et al., 2016, Using a low energy formula diet in obese patients with long-standing insulin-treated Type 2 diabetes produces significantly greater weight loss, improvement in glucose control and insulin reductions compared to gold standard clinical care over a 12 week period, Diabetic Medicine, Vol:33, ISSN:0742-3071, Pages:69-69

Bottin JH, Swann JR, Cropp E, et al., 2016, Mycoprotein reduces energy intake and postprandial insulin release without altering glucagon-like peptide-1 and peptide tyrosine-tyrosine concentrations in healthy overweight and obese adults: a randomised-controlled trial, British Journal of Nutrition, Vol:116, ISSN:0007-1145, Pages:360-374

Byrne CS, Chambers E, Alhabeeb H, et al., 2016, Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods, American Journal of Clinical Nutrition, ISSN:1938-3207

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