Imperial College London

ProfessorGaryFrost

Faculty of MedicineDepartment of Medicine

Chair in Nutrition and Dietetics
 
 
 
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Contact

 

+44 (0)20 3313 8037g.frost Website

 
 
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Location

 

Commonwealth BiuldingHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

342 results found

Johns IM, Frost GS, Dornhorst A, 2014, Plasma free fatty acids do not provide the link between obesity and insulin resistance or beta cell dysfunction: results of the RISCK study, DIABETIC MEDICINE, Vol: 31, Pages: 31-31, ISSN: 0742-3071

JOURNAL ARTICLE

Koivula RW, Heggie A, Barnett A, Cederberg H, Hansen TH, Koopman AD, Ridderstrale M, Rutters F, Vestergaard H, Gupta R, Herrgard S, Heymans MW, Perry MH, Rauh S, Siloaho M, Teare HJA, Thorand B, Bell J, Brunak S, Frost G, Jablonka B, Mari A, McDonald TJ, Dekker JM, Hansen T, Hattersley A, Laakso M, Pedersen O, Koivisto V, Ruetten H, Walker M, Pearson E, Franks PWet al., 2014, Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium, DIABETOLOGIA, Vol: 57, Pages: 1132-1142, ISSN: 0012-186X

JOURNAL ARTICLE

Psichas A, Sleeth ML, Murphy KG, Brooks L, Bewick GA, Hanyaloglu AC, Ghatei MA, Bloom SR, Frost Get al., 2014, The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents, International Journal of Obesity, Vol: 39, Pages: 424-429, ISSN: 1476-5497

JOURNAL ARTICLE

Scholtz S, Miras AD, Chhina N, Prechtl CG, Sleeth ML, Daud NM, Ismail NA, Durighel G, Ahmed AR, Olbers T, Vincent RP, Alaghband-Zadeh J, Ghatei MA, Waldman AD, Frost GS, Bell JD, le Roux CW, Goldstone APet al., 2014, Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding, GUT, Vol: 63, Pages: 891-902, ISSN: 0017-5749

JOURNAL ARTICLE

Scholtz S, Miras AD, Chhina N, Prechtl CG, Sleeth ML, Daud NM, Ismail NA, Durighel G, Ahmed AR, Olbers T, Vincent RP, Alaghband-Zadeh J, Ghatei MA, Waldman AD, Frost GS, Bell JD, le Roux CW, Goldstone APet al., 2014, Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding, GUT, Vol: 63, Pages: 891-902, ISSN: 0017-5749

JOURNAL ARTICLE

Thangarajah D, Chappell KE, Gale C, Parkinson JR, Epstein J, Hyer W, Soondrum K, Frost G, Fell JMet al., 2014, MRI assessment of body composition in paediatric Crohn's disease; intra-abdominal adipose tissue association with disease severity, JOURNAL OF CROHNS & COLITIS, Vol: 8, Pages: S239-S239, ISSN: 1873-9946

JOURNAL ARTICLE

Tripkovic L, Hart KH, Frost GS, Lodge JKet al., 2014, Interindividual and intraindividual variation in pulse wave velocity measurements in a male population, BLOOD PRESSURE MONITORING, Vol: 19, Pages: 233-241, ISSN: 1359-5237

JOURNAL ARTICLE

Aljuraiban GS, Chan Q, Griep LO, Stamler J, Van Horn L, Daviglus ML, Steffen LM, Miura K, Zhao L, Elliott P, Frost Get al., 2013, Relation of Nutrient-rich Diet to Blood Pressure and BMI: The INTERMAP Study, Scientific Sessions of the American-Heart-Association on Epidemiology and Prevention/Physical Activity, Nutrition and Metabolism, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322

CONFERENCE PAPER

Behary P, Frost G, Baynes K, 2013, Relationship between eating behaviour pattern and glycaemic control in patients with Type 2 diabetes, DIABETIC MEDICINE, Vol: 30, Pages: 177-177, ISSN: 0742-3071

JOURNAL ARTICLE

Dogan M, Brooks L, Bowe JE, Bewick GA, Frost G, Jones PM, Persaud SJet al., 2013, Expression and function of GPR43 in islets of Langerhans, DIABETIC MEDICINE, Vol: 30, Pages: 35-35, ISSN: 0742-3071

JOURNAL ARTICLE

Goff LM, Cowland DE, Hooper L, Frost GSet al., 2013, Low glycaemic index diets and blood lipids: A systematic review and meta-analysis of randomised controlled trials, NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, Vol: 23, Pages: 1-10, ISSN: 0939-4753

JOURNAL ARTICLE

Goff LM, Griffin BA, Lovegrove JA, Sanders TA, Jebb SA, Bluck LJ, Frost GSet al., 2013, Ethnic differences in beta-cell function, dietary intake and expression of the metabolic syndrome among UK adults of South Asian, black African-Caribbean and white-European origin at high risk of metabolic syndrome, DIABETES & VASCULAR DISEASE RESEARCH, Vol: 10, Pages: 315-323, ISSN: 1479-1641

JOURNAL ARTICLE

Guess ND, Dornhorst A, Frost GS, 2013, Fermentable Carbohydrate Decreases Food Intake and Promotes Weight Loss in Overweight Subjects with Prediabetes, DIABETIC MEDICINE, Vol: 30, Pages: 77-77, ISSN: 0742-3071

JOURNAL ARTICLE

Ismail NA, Posma JM, Frost G, Holmes E, Garcia-Perez Iet al., 2013, The role of metabonomics as a tool for augmenting nutritional information in epidemiological studies, ELECTROPHORESIS, Vol: 34, Pages: 2776-2786, ISSN: 0173-0835

JOURNAL ARTICLE

Jensen MG, Pedersen C, Kristensen M, Frost G, Astrup Aet al., 2013, Review: efficacy of alginate supplementation in relation to appetite regulation and metabolic risk factors: evidence from animal and human studies, OBESITY REVIEWS, Vol: 14, Pages: 129-144, ISSN: 1467-7881

JOURNAL ARTICLE

Jones J, Barr S, Jennings C, Grove T, Kotseva K, Connolly S, Dornhorst A, Frost G, Bassett P, Wood DAet al., 2013, Training opportunities in preventive cardiology: MSc, Diploma and Certificate in Preventive Cardiology, British Journal of Cardiology, Vol: 20, ISSN: 0969-6113

JOURNAL ARTICLE

Pedersen C, Lefevre S, Peters V, Patterson M, Ghatei MA, Morgan LM, Frost GSet al., 2013, Gut hormone release and appetite regulation in healthy non-obese participants following oligofructose intake. A dose-escalation study, APPETITE, Vol: 66, Pages: 44-53, ISSN: 0195-6663

JOURNAL ARTICLE

Sam A, Busbridge M, Amin A, Webber L, White D, Franks S, Martin NM, Sleeth M, Ismail NA, Daud NM, Papamargaritis D, Le Roux CW, Chapman RS, Frost G, Bloom SR, Murphy KGet al., 2013, Hepcidin levels in diabetes mellitus and polycystic ovary syndrome, Diabetic Medicine, Vol: 30, Pages: 1495-1499, ISSN: 0742-3071

JOURNAL ARTICLE

Sleeth M, Psichas A, Frost G, 2013, Weight gain and insulin sensitivity: a role for the glycaemic index and dietary fibre?, BRITISH JOURNAL OF NUTRITION, Vol: 109, Pages: 1539-1541, ISSN: 0007-1145

JOURNAL ARTICLE

Steele K, Dickin E, Keerio MD, Samad S, Kambona C, Brook R, Thomas W, Frost Get al., 2013, Breeding low-glycemic index barley for functional food, FIELD CROPS RESEARCH, Vol: 154, Pages: 31-39, ISSN: 0378-4290

JOURNAL ARTICLE

Tan S-T, Rai B, Boustead L, Badii F, Howell N, Frost G, Scott J, Elliott P, Chambers JC, Koner JSet al., 2013, Assessing the Contribution of Dietary Factors to the Increased Prevalence of Insulin Resistance Amongst Uk Indian Asians Compared to Europeans, Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322

CONFERENCE PAPER

Tan TM, Field BCT, McCullough KA, Troke RC, Chambers ES, Salem V, Maffe JG, Baynes KCR, De Silva A, Viardot A, Alsafi A, Frost GS, Ghatei MA, Bloom SRet al., 2013, Coadministration of Glucagon-Like Peptide-1 During Glucagon Infusion in Humans Results in Increased Energy Expenditure and Amelioration of Hyperglycemia, DIABETES, Vol: 62, Pages: 1131-1138, ISSN: 0012-1797

JOURNAL ARTICLE

Ahmad A, Isherwood C, Fielding BA, Bell JD, Thomas EL, Frost G, Shojaee-Moradie F, Umpleby M, Griffin BAet al., 2012, Individuals with moderately raised liver fat show a greater increase in liver fat in response to a high sugar diet, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 71, Pages: E31-E31, ISSN: 0029-6651

JOURNAL ARTICLE

Anastasovska J, Arora T, Canon GJS, Parkinson JRC, Touhy K, Gibson GR, Nadkarni NA, So P-W, Goldstone AP, Thomas EL, Hankir MK, Van Loo J, Modi N, Bell JD, Frost Get al., 2012, Fermentable Carbohydrate Alters Hypothalamic Neuronal Activity and Protects Against the Obesogenic Environment, OBESITY, Vol: 20, Pages: 1016-1023, ISSN: 1930-7381

JOURNAL ARTICLE

Arora T, Anastasovska J, Gibson G, Tuohy K, Sharma RK, Bell J, Frost Get al., 2012, Effect of Lactobacillus acidophilus NCDC 13 supplementation on the progression of obesity in diet-induced obese mice, BRITISH JOURNAL OF NUTRITION, Vol: 108, Pages: 1382-1389, ISSN: 0007-1145

JOURNAL ARTICLE

Arora T, Loo RL, Anastasovska J, Gibson GR, Tuohy KM, Sharma RK, Swann JR, Deaville ER, Sleeth ML, Thomas EL, Holmes E, Bell JD, Frost Get al., 2012, Differential Effects of Two Fermentable Carbohydrates on Central Appetite Regulation and Body Composition, PLOS ONE, Vol: 7, ISSN: 1932-6203

JOURNAL ARTICLE

Backhouse K, Sarac I, Shojaee-Moradie F, Stolinski M, Robertson MD, Frost GS, Bell JD, Thomas EL, Wright J, Russell-Jones D, Umpleby AMet al., 2012, Fatty acid flux and oxidation are increased by rimonabant in obese women, METABOLISM-CLINICAL AND EXPERIMENTAL, Vol: 61, Pages: 1220-1223, ISSN: 0026-0495

JOURNAL ARTICLE

Bell J, Frost G, Thomas E, Brody L, Arisoylu M, Miller Aet al., 2012, Liposome encapsulated acetate (Lita) for the treatment of metabolic and oncogenic diseases

Cellular metabolic deregulation is a central premise in the development of many chronic diseases including cancer. Recently, there has been renewed interest in the potential of metabolic engineering, through the use of small molecules, to achieve metabolic retransformation of abnormal cells and tissues. However, making sufficient and sustain metabolic impact though this methods can be difficult, as it requires both identification of suitable small molecule(s) and an appropriate mode of delivery. Here we present a unique approach to tackle metabolic deregulation in vivo by the use of short-chain fatty acids (SCFAs) encapsulated in a liposomal nanoparticle delivery system. We demonstrate that liposomal delivery of the SCFA acetate leads to improved metabolic fitness of several organs, including liver and adipose tissue. Furthermore, treatment of mice consuming a high fat diet resulted in a significant reduction in hepatic fat accumulation, a reduction in inflammatory markers and modulation in key genes associated with fat metabolism, including UCP2, ACOX1 and CPT1A. These phenotypic and molecular events were underpinned by modulations in the epigenetic regulation of the liver. Finally, significant antitumor effects were observed in a xenograft murine model, including significant inhibition of tumour growth, following treatment. Our results demonstrate that this delivery system, liposomal encapsulated SCFAs, can be utilised as a novel method for the treatment of malignant transformation and metabolic deregulation in vivo.

PATENT

Bell-Higgs AE, Brosnahan NT, Clarke AM, Dow MSA, Haynes SM, Lyons GF, McCombie E, Mongia S, Noble PA, Quinn MF, Regan PJ, Ross HM, Thompson FE, Vermeulen A, Broom JI, Reckless JPD, Kumar S, Lean MEJ, Frost GS, Finer N, Haslam DW, Morrison D, Sloan B, McLoone Pet al., 2012, The implementation of the Counterweight Programme in Scotland, UK, FAMILY PRACTICE, Vol: 29, Pages: i139-i144, ISSN: 0263-2136

JOURNAL ARTICLE

Bodinham CL, Smith L, Wright J, Frost GS, Robertson MDet al., 2012, Dietary Fibre Improves First-phase Insulin Secretion in Overweight Individuals, PLOS ONE, Vol: 7, ISSN: 1932-6203

JOURNAL ARTICLE

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