Imperial College London

ProfessorGaryFrost

Faculty of MedicineDepartment of Medicine

Chair in Nutrition and Dietetics
 
 
 
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Contact

 

+44 (0)20 3313 8037g.frost Website

 
 
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Location

 

Commonwealth BiuldingHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

345 results found

Bell J, Frost G, Thomas E, Brody L, Arisoylu M, Miller Aet al., 2012, Liposome encapsulated acetate (Lita) for the treatment of metabolic and oncogenic diseases

Cellular metabolic deregulation is a central premise in the development of many chronic diseases including cancer. Recently, there has been renewed interest in the potential of metabolic engineering, through the use of small molecules, to achieve metabolic retransformation of abnormal cells and tissues. However, making sufficient and sustain metabolic impact though this methods can be difficult, as it requires both identification of suitable small molecule(s) and an appropriate mode of delivery. Here we present a unique approach to tackle metabolic deregulation in vivo by the use of short-chain fatty acids (SCFAs) encapsulated in a liposomal nanoparticle delivery system. We demonstrate that liposomal delivery of the SCFA acetate leads to improved metabolic fitness of several organs, including liver and adipose tissue. Furthermore, treatment of mice consuming a high fat diet resulted in a significant reduction in hepatic fat accumulation, a reduction in inflammatory markers and modulation in key genes associated with fat metabolism, including UCP2, ACOX1 and CPT1A. These phenotypic and molecular events were underpinned by modulations in the epigenetic regulation of the liver. Finally, significant antitumor effects were observed in a xenograft murine model, including significant inhibition of tumour growth, following treatment. Our results demonstrate that this delivery system, liposomal encapsulated SCFAs, can be utilised as a novel method for the treatment of malignant transformation and metabolic deregulation in vivo.

PATENT

Bell-Higgs AE, Brosnahan NT, Clarke AM, Dow MSA, Haynes SM, Lyons GF, McCombie E, Mongia S, Noble PA, Quinn MF, Regan PJ, Ross HM, Thompson FE, Vermeulen A, Broom JI, Reckless JPD, Kumar S, Lean MEJ, Frost GS, Finer N, Haslam DW, Morrison D, Sloan B, McLoone Pet al., 2012, The implementation of the Counterweight Programme in Scotland, UK, FAMILY PRACTICE, Vol: 29, Pages: i139-i144, ISSN: 0263-2136

JOURNAL ARTICLE

Bodinham CL, Smith L, Wright J, Frost GS, Robertson MDet al., 2012, Dietary Fibre Improves First-phase Insulin Secretion in Overweight Individuals, PLOS ONE, Vol: 7, ISSN: 1932-6203

JOURNAL ARTICLE

Carter M, Alwan NA, Burley V, Wark PA, Evans CE, Greenwood DC, Hardie LJ, Frost G, Cade JEet al., 2012, Use of information and communication technology to improve dietary assessment and tackle obesity, Public Health Science: a national conference dedicated to new research in public health

CONFERENCE PAPER

Darzi J, Frost GS, Robertson MD, 2012, Effects of a novel propionate-rich sourdough bread on appetite and food intake, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 66, Pages: 789-794, ISSN: 0954-3007

JOURNAL ARTICLE

Frost G, Wilkinson J, 2012, Compounds and their effects on appetite control and insulin sensitivity

Imperial innovations filed a UK priority patent application No1213629.7 entitled “compounds and their effects on appetite control and insulin sensitivity” in the name of Imperial Innovations and the University of Glasgow on the 31st of July 2012. We have filed a subsequent PCT application on the 31st of July 2013. The covers composition of matter and on a number of [novel prodrugs] or [propionate inulin esters] specifically designed to deliver short chain fatty acids to the gut. The patent also has claims directed to formulations and use in reduction of appetite/food intake/calorie intake. Claims are also directed and improving insulin sensitivity in a subject and for the treatment or prevention of diabetes or obesity.

PATENT

Hill NE, Murphy KG, Brett S, Wilson DR, Frost G, Dhillo W, Bloom SR, Singer Met al., 2012, CAN THE GASTRIC HORMONE GHRELIN ATTENUATE CATABOLISM AND ENHANCE RECOVERY AND REHABILITATION IN A RODENT MODEL OF ZYMOSAN PERITONITIS?, INTENSIVE CARE MEDICINE, Vol: 38, Pages: S122-S122, ISSN: 0342-4642

JOURNAL ARTICLE

Joosen AM, Clarke MM, Lodge JK, Mugridge O, Frost G, Engel B, Taillart K, Lloyd AJ, Beckmann M, Draper Jet al., 2012, Development of a biomarker for sucrose intake based on metabolomics, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 71, Pages: E188-E188, ISSN: 0029-6651

JOURNAL ARTICLE

Liu J, Johns E, Atallah L, Pettitt C, Lo B, Frost G, Yang GZet al., 2012, An intelligent food-intake monitoring system using wearable sensors, Proceedings - BSN 2012: 9th International Workshop on Wearable and Implantable Body Sensor Networks, Pages: 154-160

The prevalence of obesity worldwide presents a great challenge to existing healthcare systems. There is a general need for pervasive monitoring of the dietary behaviour of those who are at risk of co-morbidities. Currently, however, there is no accurate method of assessing the nutritional intake of people in their home environment. Traditional methods require subjects to manually respond to questionnaires for analysis, which is subjective, prone to errors, and difficult to ensure consistency and compliance. In this paper, we present a wearable sensor platform that autonomously provides detailed information regarding a subject's dietary habits. The sensor consists of a microphone and a camera and is worn discretely on the ear. Sound features are extracted in real-time and if a chewing activity is classified, the camera captures a video sequence for further analysis. From this sequence, a number of key frames are extracted to represent important episodes during the course of a meal. Results show a high classification rate of chewing activities, and the visual log demonstrates a detailed overview of the subject's food intake that is difficult to quantify from manually-acquired food records. © 2012 IEEE.

JOURNAL ARTICLE

Morgan LM, Shi J-W, Hampton SM, Frost Get al., 2012, Effect of meal timing and glycaemic index on glucose control and insulin secretion in healthy volunteers, BRITISH JOURNAL OF NUTRITION, Vol: 108, Pages: 1286-1291, ISSN: 0007-1145

JOURNAL ARTICLE

Moss C, Dhillo WS, Frost G, Hickson Met al., 2012, Gastrointestinal hormones: the regulation of appetite and the anorexia of ageing, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 25, Pages: 3-15, ISSN: 0952-3871

JOURNAL ARTICLE

Thomas EL, Al Saud NB, Durighel G, Frost G, Bell JDet al., 2012, The effect of preterm birth on adiposity and metabolic pathways and the implications for later life, CLINICAL LIPIDOLOGY, Vol: 7, Pages: 275-288, ISSN: 1758-4299

JOURNAL ARTICLE

Thomas EL, Frost G, Taylor-Robinson SD, Bell JDet al., 2012, Excess body fat in obese and normal-weight subjects, NUTRITION RESEARCH REVIEWS, Vol: 25, Pages: 150-161, ISSN: 0954-4224

JOURNAL ARTICLE

Thomas EL, Parkinson JR, Frost GS, Goldstone AP, Dore CJ, McCarthy JP, Collins AL, Fitzpatrick JA, Durighel G, Taylor-Robinson SD, Bell JDet al., 2012, The Missing Risk: MRI and MRS Phenotyping of Abdominal Adiposity and Ectopic Fat, OBESITY, Vol: 20, Pages: 76-87, ISSN: 1930-7381

JOURNAL ARTICLE

Walker CG, Loos RJF, Mander AP, Jebb SA, Frost GS, Griffin BA, Lovegrove JA, Sanders TAB, Bluck LJet al., 2012, Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat, GENES AND NUTRITION, Vol: 7, Pages: 529-536, ISSN: 1555-8932

JOURNAL ARTICLE

Ahmad A, Isherwood C, Bell JD, Thomas EL, Frost G, Umpleby M, Griffin BAet al., 2011, Impact of liver fat on the response of plasma triacylglycerol to diets high and low in extrinsic sugars, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 70, Pages: E364-E364, ISSN: 0029-6651

JOURNAL ARTICLE

Al-Mssallem MQ, Hampton SM, Frost GS, Brown JEet al., 2011, A study of Hassawi rice (Oryza sativa L.) in terms of its carbohydrate hydrolysis (in vitro) and glycaemic and insulinaemic indices (in vivo), EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 65, Pages: 627-634, ISSN: 0954-3007

JOURNAL ARTICLE

AlSaleh A, Frost GS, Griffin BA, Lovegrove JA, Jebb SA, Sanders TAB, O'Dell SDet al., 2011, PPAR gamma 2 Gene Pro12Ala and PPAR alpha Gene Leu162Val Single Nucleotide Polymorphisms Interact with Dietary Intake of Fat in Determination of Plasma Lipid Concentrations, JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS, Vol: 4, Pages: 354-366, ISSN: 1661-6499

JOURNAL ARTICLE

AlSaleh A, O'Dell SD, Frost GS, Griffin BA, Lovegrove JA, Jebb SA, Sanders TABet al., 2011, Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 94, Pages: 262-269, ISSN: 0002-9165

JOURNAL ARTICLE

AlSaleh A, O'Dell SD, Frost GS, Griffin BA, Lovegrove JA, Jebb SA, Sanders TABet al., 2011, Interaction of PPARG Pro12Ala with dietary fat influences plasma lipids in subjects at cardiometabolic risk, JOURNAL OF LIPID RESEARCH, Vol: 52, Pages: 2298-2303, ISSN: 0022-2275

JOURNAL ARTICLE

Arora T, Sharma R, Frost G, 2011, Propionate. Anti-obesity and satiety enhancing factor?, APPETITE, Vol: 56, Pages: 511-515, ISSN: 0195-6663

JOURNAL ARTICLE

Bodinham CL, Hitchen KL, Youngman PJ, Frost GS, Robertson MDet al., 2011, Short-term effects of whole-grain wheat on appetite and food intake in healthy adults: a pilot study, BRITISH JOURNAL OF NUTRITION, Vol: 106, Pages: 327-330, ISSN: 0007-1145

JOURNAL ARTICLE

Bodinham CL, Smith L, Wright JW, Frost GS, Robertson MDet al., 2011, The effects of resistant starch on appetite, food intake and insulin, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 70, Pages: E182-E182, ISSN: 0029-6651

JOURNAL ARTICLE

Bottin J, Cropp E, Ford H, Betremieux L, Finnigan T, Frost Get al., 2011, Mycoprotein reduces insulinemia and improves insulin sensitivity, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 70, Pages: E372-E372, ISSN: 0029-6651

JOURNAL ARTICLE

Darzi J, Frost GS, Robertson MD, 2011, Postgraduate Symposium Do SCFA have a role in appetite regulation?, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 70, Pages: 119-128, ISSN: 0029-6651

JOURNAL ARTICLE

Daud NM, Ismail N, Thomas EL, Scholtz S, Durighel G, Fitzpatrick JA, Goldstone AP, Bell JD, Bech PR, Chambers E, Chhina N, Ghatei MA, Pedersen C, Frost GSet al., 2011, Effects of 8 weeks oligofructose supplementation on appetite and body weight in overweight and obese adults, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 70, Pages: E374-E374, ISSN: 0029-6651

JOURNAL ARTICLE

Dickin E, Steele K, Frost G, Edwards-Jones G, Wright Det al., 2011, Effect of genotype, environment and agronomic management on beta-glucan concentration of naked barley grain intended for health food use, JOURNAL OF CEREAL SCIENCE, Vol: 54, Pages: 44-52, ISSN: 0733-5210

JOURNAL ARTICLE

Dyson PA, Kelly T, Deakin T, Duncan A, Frost G, Harrison Z, Khatri D, Kunka D, McArdle P, Mellor D, Oliver L, Worth Jet al., 2011, Diabetes UK evidence-based nutrition guidelines for the prevention and management of diabetes, DIABETIC MEDICINE, Vol: 28, Pages: 1282-1288, ISSN: 0742-3071

JOURNAL ARTICLE

Ford HE, Peters V, Martin NM, Sleeth ML, Ghatei MA, Frost GS, Bloom SRet al., 2011, Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 65, Pages: 508-513, ISSN: 0954-3007

JOURNAL ARTICLE

Isherwood C, Ahmad A, Lovegrove JA, Frost GS, Umpleby AM, Griffin BAet al., 2011, Dietary exchange model to investigate the metabolic effects of extrinsic sugars on an atherogenic lipoprotein phenotype, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 70, Pages: E221-E221, ISSN: 0029-6651

JOURNAL ARTICLE

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