351 results found
Ahmad A, Isherwood C, Fielding BA, et al., 2012, Individuals with moderately raised liver fat show a greater increase in liver fat in response to a high sugar diet, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 71, Pages: E31-E31, ISSN: 0029-6651
Anastasovska J, Arora T, Canon GJS, et al., 2012, Fermentable Carbohydrate Alters Hypothalamic Neuronal Activity and Protects Against the Obesogenic Environment, OBESITY, Vol: 20, Pages: 1016-1023, ISSN: 1930-7381
Arora T, Anastasovska J, Gibson G, et al., 2012, Effect of Lactobacillus acidophilus NCDC 13 supplementation on the progression of obesity in diet-induced obese mice, BRITISH JOURNAL OF NUTRITION, Vol: 108, Pages: 1382-1389, ISSN: 0007-1145
Arora T, Loo RL, Anastasovska J, et al., 2012, Differential Effects of Two Fermentable Carbohydrates on Central Appetite Regulation and Body Composition, PLOS ONE, Vol: 7, ISSN: 1932-6203
Backhouse K, Sarac I, Shojaee-Moradie F, et al., 2012, Fatty acid flux and oxidation are increased by rimonabant in obese women, METABOLISM-CLINICAL AND EXPERIMENTAL, Vol: 61, Pages: 1220-1223, ISSN: 0026-0495
Bell J, Frost G, Thomas E, et al., 2012, Liposome encapsulated acetate (Lita) for the treatment of metabolic and oncogenic diseases
Cellular metabolic deregulation is a central premise in the development of many chronic diseases including cancer. Recently, there has been renewed interest in the potential of metabolic engineering, through the use of small molecules, to achieve metabolic retransformation of abnormal cells and tissues. However, making sufficient and sustain metabolic impact though this methods can be difficult, as it requires both identification of suitable small molecule(s) and an appropriate mode of delivery. Here we present a unique approach to tackle metabolic deregulation in vivo by the use of short-chain fatty acids (SCFAs) encapsulated in a liposomal nanoparticle delivery system. We demonstrate that liposomal delivery of the SCFA acetate leads to improved metabolic fitness of several organs, including liver and adipose tissue. Furthermore, treatment of mice consuming a high fat diet resulted in a significant reduction in hepatic fat accumulation, a reduction in inflammatory markers and modulation in key genes associated with fat metabolism, including UCP2, ACOX1 and CPT1A. These phenotypic and molecular events were underpinned by modulations in the epigenetic regulation of the liver. Finally, significant antitumor effects were observed in a xenograft murine model, including significant inhibition of tumour growth, following treatment. Our results demonstrate that this delivery system, liposomal encapsulated SCFAs, can be utilised as a novel method for the treatment of malignant transformation and metabolic deregulation in vivo.
Bell-Higgs AE, Brosnahan NT, Clarke AM, et al., 2012, The implementation of the Counterweight Programme in Scotland, UK, FAMILY PRACTICE, Vol: 29, Pages: i139-i144, ISSN: 0263-2136
Bodinham CL, Smith L, Wright J, et al., 2012, Dietary Fibre Improves First-phase Insulin Secretion in Overweight Individuals, PLOS ONE, Vol: 7, ISSN: 1932-6203
Carter M, Alwan NA, Burley V, et al., 2012, Use of information and communication technology to improve dietary assessment and tackle obesity, Public Health Science: a national conference dedicated to new research in public health
Darzi J, Frost GS, Robertson MD, 2012, Effects of a novel propionate-rich sourdough bread on appetite and food intake, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 66, Pages: 789-794, ISSN: 0954-3007
Frost G, Dornhorst A, 2012, Glycemic Index, Encyclopedia of Human Nutrition, Pages: 393-398, ISBN: 9780123848857
© 2013 Elsevier Ltd. All rights reserved. In the past 10 years, a number of important epidemiological and experimental studies have linked glycemic index to postprandial glucose metabolism, insulin resistance, and cardiovascular risk factors. The World Health Organization and the Food and Agriculture Organization recommended that the physiological effects of dietary carbohydrates be classified according to their glycemic index. This review examines the historical and scientific background of the glycemic index.
Frost G, Wilkinson J, 2012, Compounds and their effects on appetite control and insulin sensitivity
Imperial innovations filed a UK priority patent application No1213629.7 entitled “compounds and their effects on appetite control and insulin sensitivity” in the name of Imperial Innovations and the University of Glasgow on the 31st of July 2012. We have filed a subsequent PCT application on the 31st of July 2013. The covers composition of matter and on a number of [novel prodrugs] or [propionate inulin esters] specifically designed to deliver short chain fatty acids to the gut. The patent also has claims directed to formulations and use in reduction of appetite/food intake/calorie intake. Claims are also directed and improving insulin sensitivity in a subject and for the treatment or prevention of diabetes or obesity.
Hill NE, Murphy KG, Brett S, et al., 2012, CAN THE GASTRIC HORMONE GHRELIN ATTENUATE CATABOLISM AND ENHANCE RECOVERY AND REHABILITATION IN A RODENT MODEL OF ZYMOSAN PERITONITIS?, INTENSIVE CARE MEDICINE, Vol: 38, Pages: S122-S122, ISSN: 0342-4642
Joosen AM, Clarke MM, Lodge JK, et al., 2012, Development of a biomarker for sucrose intake based on metabolomics, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 71, Pages: E188-E188, ISSN: 0029-6651
Liu J, Johns E, Atallah L, et al., 2012, An intelligent food-intake monitoring system using wearable sensors, Proceedings - BSN 2012: 9th International Workshop on Wearable and Implantable Body Sensor Networks, Pages: 154-160
The prevalence of obesity worldwide presents a great challenge to existing healthcare systems. There is a general need for pervasive monitoring of the dietary behaviour of those who are at risk of co-morbidities. Currently, however, there is no accurate method of assessing the nutritional intake of people in their home environment. Traditional methods require subjects to manually respond to questionnaires for analysis, which is subjective, prone to errors, and difficult to ensure consistency and compliance. In this paper, we present a wearable sensor platform that autonomously provides detailed information regarding a subject's dietary habits. The sensor consists of a microphone and a camera and is worn discretely on the ear. Sound features are extracted in real-time and if a chewing activity is classified, the camera captures a video sequence for further analysis. From this sequence, a number of key frames are extracted to represent important episodes during the course of a meal. Results show a high classification rate of chewing activities, and the visual log demonstrates a detailed overview of the subject's food intake that is difficult to quantify from manually-acquired food records. © 2012 IEEE.
Morgan LM, Shi J-W, Hampton SM, et al., 2012, Effect of meal timing and glycaemic index on glucose control and insulin secretion in healthy volunteers, BRITISH JOURNAL OF NUTRITION, Vol: 108, Pages: 1286-1291, ISSN: 0007-1145
Moss C, Dhillo WS, Frost G, et al., 2012, Gastrointestinal hormones: the regulation of appetite and the anorexia of ageing, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 25, Pages: 3-15, ISSN: 0952-3871
Thomas EL, Al Saud NB, Durighel G, et al., 2012, The effect of preterm birth on adiposity and metabolic pathways and the implications for later life, CLINICAL LIPIDOLOGY, Vol: 7, Pages: 275-288, ISSN: 1758-4299
Thomas EL, Frost G, Taylor-Robinson SD, et al., 2012, Excess body fat in obese and normal-weight subjects, NUTRITION RESEARCH REVIEWS, Vol: 25, Pages: 150-161, ISSN: 0954-4224
Thomas EL, Parkinson JR, Frost GS, et al., 2012, The Missing Risk: MRI and MRS Phenotyping of Abdominal Adiposity and Ectopic Fat, OBESITY, Vol: 20, Pages: 76-87, ISSN: 1930-7381
Walker CG, Loos RJF, Mander AP, et al., 2012, Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat, GENES AND NUTRITION, Vol: 7, Pages: 529-536, ISSN: 1555-8932
Ahmad A, Isherwood C, Bell JD, et al., 2011, Impact of liver fat on the response of plasma triacylglycerol to diets high and low in extrinsic sugars, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 70, Pages: E364-E364, ISSN: 0029-6651
Al-Mssallem MQ, Hampton SM, Frost GS, et al., 2011, A study of Hassawi rice (Oryza sativa L.) in terms of its carbohydrate hydrolysis (in vitro) and glycaemic and insulinaemic indices (in vivo), EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 65, Pages: 627-634, ISSN: 0954-3007
AlSaleh A, Frost GS, Griffin BA, et al., 2011, PPAR gamma 2 Gene Pro12Ala and PPAR alpha Gene Leu162Val Single Nucleotide Polymorphisms Interact with Dietary Intake of Fat in Determination of Plasma Lipid Concentrations, JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS, Vol: 4, Pages: 354-366, ISSN: 1661-6499
AlSaleh A, O'Dell SD, Frost GS, et al., 2011, Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 94, Pages: 262-269, ISSN: 0002-9165
AlSaleh A, O'Dell SD, Frost GS, et al., 2011, Interaction of PPARG Pro12Ala with dietary fat influences plasma lipids in subjects at cardiometabolic risk, JOURNAL OF LIPID RESEARCH, Vol: 52, Pages: 2298-2303, ISSN: 0022-2275
Arora T, Sharma R, Frost G, 2011, Propionate. Anti-obesity and satiety enhancing factor?, APPETITE, Vol: 56, Pages: 511-515, ISSN: 0195-6663
Bodinham CL, Hitchen KL, Youngman PJ, et al., 2011, Short-term effects of whole-grain wheat on appetite and food intake in healthy adults: a pilot study, BRITISH JOURNAL OF NUTRITION, Vol: 106, Pages: 327-330, ISSN: 0007-1145
Bodinham CL, Smith L, Wright JW, et al., 2011, The effects of resistant starch on appetite, food intake and insulin, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 70, Pages: E182-E182, ISSN: 0029-6651
Bottin J, Cropp E, Ford H, et al., 2011, Mycoprotein reduces insulinemia and improves insulin sensitivity, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 70, Pages: E372-E372, ISSN: 0029-6651
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