Imperial College London

ProfessorGaryFrost

Faculty of MedicineDepartment of Medicine

Chair in Nutrition and Dietetics
 
 
 
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Contact

 

+44 (0)20 7594 0959g.frost Website

 
 
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Location

 

Commonwealth BiuldingHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

355 results found

Trueman P, Haynes SM, Felicity Lyons G, Louise McCombie E, McQuigg MS, Mongia S, Noble PA, Quinn MF, Ross HM, Thompson F, Broom JI, Laws RA, Reckless JP, Kumar S, Lean ME, Frost GS, Finer N, Haslam DW, Morrison D, Sloan Bet al., 2010, Long-term cost-effectiveness of weight management in primary care, Vol: 64, Pages: 775-783, ISSN: 1742-1241

JOURNAL ARTICLE

Trueman P, Haynes SM, Lyons GF, McCombie EL, McQuigg MSA, Mongia S, Noble PA, Quinn MF, Ross HM, Thompson F, Broom JI, Laws RA, Reckless JPD, Kumar S, Lean MEJ, Frost GS, Finer N, Haslam DW, Morrison D, Sloan Bet al., 2010, Long-term cost-effectiveness of weight management in primary care, INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Vol: 64, Pages: 775-783, ISSN: 1368-5031

JOURNAL ARTICLE

Calder PC, Albers R, Antoine J-M, Blum S, Bourdet-Sicard R, Ferns GA, Folkerts G, Friedmann PS, Frost GS, Guarner F, Lovik M, Macfarlane S, Meyer PD, M'Rabet L, Serafini M, van Eden W, van Loo J, Dias WV, Vidry S, Winklhofer-Roob BM, Zhao Jet al., 2009, Inflammatory Disease Processes and Interactions with Nutrition, BRITISH JOURNAL OF NUTRITION, Vol: 101, Pages: S1-+, ISSN: 0007-1145

JOURNAL ARTICLE

Ceriello A, Lansink M, Rouws CHFC, van Laere KMJ, Frost GSet al., 2009, Administration of a new diabetes-specific enteral formula results in an improved 24 h glucose profile in type 2 diabetic patients, DIABETES RESEARCH AND CLINICAL PRACTICE, Vol: 84, Pages: 259-266, ISSN: 0168-8227

JOURNAL ARTICLE

Goldstone AP, de Hernandez CGP, Beaver JD, Muhammed K, Croese C, Bell G, Durighel G, Hughes E, Waldman AD, Frost G, Bell JDet al., 2009, Fasting biases brain reward systems towards high-calorie foods, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 30, Pages: 1625-1635, ISSN: 0953-816X

JOURNAL ARTICLE

Hickson M, Macqueen C, Frost G, 2009, Evaluation of attendance and weight loss in an intensive weight management clinic compared to standard dietetic care, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 22, Pages: 72-76, ISSN: 0952-3871

JOURNAL ARTICLE

Johnston JD, Frost G, Otway DT, 2009, Adipose tissue, adipocytes and the circadian timing system, OBESITY REVIEWS, Vol: 10, Pages: 52-60, ISSN: 1467-7881

JOURNAL ARTICLE

Kazempour Ardebili S, Lecamwasam VL, Dassanyake T, Frankel AH, Tam FWK, Dornhorst A, Frost G, Turner JJOet al., 2009, Assessing Glycemic Control in Maintenance Hemodialysis Patients With Type 2 Diabetes, Diabetes Care, Vol: 32, Pages: 1137-1142, ISSN: 1935-5548

JOURNAL ARTICLE

Kazempour-Ardebili S, Lecamwasam VL, Dassanyake T, Frankel AH, Tam FW, Dornhorst A, Frost G, Turner JJet al., 2009, Assessing glycemic control in maintenance hemodialysis patients with type 2 diabetes, Vol: 32, Pages: 1137-1142, ISSN: 1935-5548

JOURNAL ARTICLE

Kazempour-Ardebili S, Lecamwasam VL, Dassanyake T, Frankel AH, Tam FWK, Dorn-Horst A, Frost G, Turner JJOet al., 2009, Assessing Glycaemic Control in Maintenance Haemodialysis Patients with Type 2 Diabetes, DIABETES, Vol: 58, Pages: A106-A106, ISSN: 0012-1797

JOURNAL ARTICLE

Kazempour-Ardebili S, Lecamwasam VL, Dassanyake T, Frankel AH, Tam FWK, Dornhorst A, Frost G, Turner JJOet al., 2009, Assessing glycemic control in maintenance hemodialysis patients with type 2 diabetes: Response to Riveline and Hadjadj, Diabetes Care, Vol: 32, ISSN: 0149-5992

JOURNAL ARTICLE

Mead A, Jennings C, Jones J, Turner EL, Connolly SB, Kotseva K, De Backer G, De Bacquer D, Frost G, Wood Det al., 2009, Less weight gain and a healthier lifestyle after quitting smoking in EUROACTION: a family based preventive cardiology programme for coronary patients, EUROPEAN HEART JOURNAL, Vol: 30, Pages: 77-77, ISSN: 0195-668X

JOURNAL ARTICLE

Moore C, Gitau R, Goff L, Lewis FJ, Griffin MD, Chatfield MD, Jebb SA, Frost GS, Sanders TAB, Griffin BA, Lovegrove JAet al., 2009, Successful Manipulation of the Quality and Quantity of Fat and Carbohydrate Consumed by Free-Living Individuals Using a Food Exchange Model, JOURNAL OF NUTRITION, Vol: 139, Pages: 1534-1540, ISSN: 0022-3166

JOURNAL ARTICLE

Otway DT, Frost G, Johnston JD, 2009, CIRCADIAN RHYTHMICITY INMURINE PRE-ADIPOCYTE AND ADIPOCYTE CELLS, CHRONOBIOLOGY INTERNATIONAL, Vol: 26, Pages: 1340-1354, ISSN: 0742-0528

JOURNAL ARTICLE

Philippou E, Bovill-Taylor C, Rajkumar C, Vampa ML, Ntatsaki E, Brynes AE, Hickson M, Frost GSet al., 2009, Preliminary report: the effect of a 6-month dietary glycemic index manipulation in addition to healthy eating advice and weight loss on arterial compliance and 24-hour ambulatory blood pressure in men: a pilot study, METABOLISM-CLINICAL AND EXPERIMENTAL, Vol: 58, Pages: 1703-1708, ISSN: 0026-0495

JOURNAL ARTICLE

Philippou E, Bovill-Taylor C, Rajkumar C, Vampa ML, Ntatsaki E, Brynes AE, Hickson M, Frost GSet al., 2009, Preliminary report: the effect of a 6-month dietary glycemic index manipulation in addition to healthy eating advice and weight loss on arterial compliance and 24-hour ambulatory blood pressure in men: a pilot study, Vol: 58, Pages: 1703-1708, ISSN: 1532-8600

JOURNAL ARTICLE

Philippou E, Neary NM, Chaudhri O, Brynes AE, Dornhorst A, Leeds AR, Hickson M, Frost GSet al., 2009, The Effect of Dietary Glycemic Index on Weight Maintenance in Overweight Subjects: A Pilot Study, OBESITY, Vol: 17, Pages: 396-401, ISSN: 1930-7381

JOURNAL ARTICLE

Philippou E, Neary NM, Chaudhri O, Brynes AE, Dornhorst A, Leeds AR, Hickson M, Frost GSet al., 2009, The effect of dietary glycemic index on weight maintenance in overweight subjects: a pilot study, Vol: 17, Pages: 396-401, ISSN: 1930-7381

JOURNAL ARTICLE

Barratt R, Frost G, Millward DJ, Truby Het al., 2008, A randomised controlled trial investigating the effect of an intensive lifestyle intervention v. standard care in adults with type 2 diabetes immediately after initiating insulin therapy, BRITISH JOURNAL OF NUTRITION, Vol: 99, Pages: 1025-1031, ISSN: 0007-1145

JOURNAL ARTICLE

Barratt R, Frost G, O'Boyle A, Millward J, Truby Het al., 2008, Use of sibutramine to assist obese women with weight loss can be successful in dietitian-led clinics: another tool in the dietitian's toolbox, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 21, Pages: 248-255, ISSN: 0952-3871

JOURNAL ARTICLE

Barratt R, Frost G, O'Boyle A, Millward J, Truby Het al., 2008, Use of sibutramine to assist obese women with weight loss can be successful in dietitian-led clinics: another tool in the dietitian's toolbox (vol 21, pg 248, 2008), JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 21, Pages: 525-525, ISSN: 0952-3871

JOURNAL ARTICLE

Calder PC, Albers R, Antoine JM, Blum S, Bourdet-Sicard R, Ferns GA, Folkerts G, Friedmann PS, Frost GS, Guarner F, Løvik M, Macfarlane S, Meyer PD, M'Rabet L, Serafini M, Van Eden W, Van Loo J, Vas Dias W, Vidry S, Winklhofer-Roob BM, Zhao Jet al., 2008, Nutrition and inflammatory processes, Proceedings of the Nutrition Society, Vol: 67, ISSN: 0029-6651

JOURNAL ARTICLE

Counterweight Project Team, 2008, Evaluation of the Counterweight Programme for obesity management in primary care: a starting point for continuous improvement., Br J Gen Pract, Vol: 58, Pages: 548-554, ISSN: 0960-1643

BACKGROUND: Evaluation for obesity management in primary care is limited, and successful outcomes are from intensive clinical trials in hospital settings. AIM: To determine to what extent measures of success seen in intensive clinical trials can be achieved in routine primary care. Primary outcome measures were weight change and percentage of patients achieving >or=5% loss at 12 and 24 months. DESIGN OF STUDY: Prospective evaluation of a new continuous improvement model for weight management in primary care. SETTING: Primary care, UK. METHOD: Primary care practice nurses from 65 UK general practices delivered interventions to 1906 patients with body mass index (BMI)>or=30 kg/m2 or>or=28 kg/m2 with obesity-related comorbidities. RESULTS: Mean baseline weight was 101.2 kg (BMI 37.1 kg/m2); 25% of patients had BMI>or=40 kg/m2 and 74% had >or=1 major obesity-related comorbidity. At final data capture 1419 patients were in the programme for >or=12 months, and 825 for >or=24 months. Mean weight change in those who attended and had data at 12 months (n=642) was -3.0 kg (95% CI=-3.5 to -2.4 kg) and at 24 months (n=357) was -2.3 kg (95% CI=-3.2 to -1.4 kg). Among attenders at specific time-points, 30.7% had maintained weight loss of >or=5% at 12 months, and 31.9% at 24 months. A total of 761 (54%) of all 1419 patients who had been enrolled in the programme for >12 months provided data at or beyond 12 months. CONCLUSION: This intervention achieves and maintains clinically valuable weight loss within routine primary care.

JOURNAL ARTICLE

Jadin L, Wu X, Ding H, Frost GI, Onclinx C, Triggs-Raine B, Flamion Bet al., 2008, Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX?, FASEB J, Vol: 22, Pages: 4316-4326

The metabolism of hyaluronan (HA) relies on HA synthases and hyaluronidases, among which hyaluronidase-1 (HYAL1) and -2 (HYAL2) have been proposed as key actors. Congenital HYAL1 deficiency leads to mucopolysaccharidosis IX (MPS IX), a rare lysosomal storage disorder characterized by joint abnormalities. Knowledge of HYAL2 is limited. This protein displays weak in vitro hyaluronidase activity and acts as a receptor for oncogenic ovine retroviruses. We have generated HYAL2-deficient mice through a conditional Cre-lox system. Hyal2(-/-) mice are viable and fertile. They exhibit localized congenital defects in frontonasal and vertebral bone formation and suffer from mild thrombocytopenia and chronic, possibly intravascular, hemolysis. In addition, Hyal2(-/-) mice display 10-fold increases in plasma levels of HA and 2-fold increases in plasma hyaluronidase activity. Globally, there is no HA accumulation in tissues, including bones, but liver sinusoidal cells seem overloaded with undigested HA. Taken together, these elements demonstrate for the first time that murine HYAL2 has a physiological activity in vivo that is relevant for craniovertebral bone formation, maintenance of plasma HA concentrations, and erythrocyte and platelet homeostasis. In addition, the viability of HYAL2-deficient mice raises the possibility that a similar defect, defining a new MPS disorder, exists in humans.

JOURNAL ARTICLE

Lansink M, van Laere KM, Rouws CH, Frost Get al., 2008, Administration of a new diabetes-specific enteral formula significantly improves 24 hour glucose profile in diabetic patients, 67th Annual Meeting of the American-Diabetes-Association, Publisher: AMER DIABETES ASSOC, Pages: A468-A468, ISSN: 0012-1797

CONFERENCE PAPER

McQuigg M, Broom JI, Laws RA, Reckless JPD, Noble PA, Kumar S, McCombie EL, Lean MEJ, Lyons GF, Frost GS, Quinn MF, Barth JH, Haynes SM, Finer N, Haslam DW, Ross HMet al., 2008, Tricks and tools for the primary care provider - The Counterweight Programme: a continuous improvement methodology model of weight management in UK primary care, 16th European Congress on Obesity, Publisher: NATURE PUBLISHING GROUP, Pages: S6-S6, ISSN: 0307-0565

CONFERENCE PAPER

McQuigg M, Brown JE, Broom J, Laws RA, Reckless JPD, Noble PA, Kumar S, McCombie EL, Lean MEJ, Lyons FG, Frost GS, Quinn MF, Barth JH, Haynes SM, Finer N, Haslam DW, Ross HM, Hole DJ, Radziwonik Set al., 2008, The Counterweight programme: Prevalence of CVD risk factors by body mass index and the impact of 10% weight change, OBESITY RESEARCH & CLINICAL PRACTICE, Vol: 2, Pages: 15-27, ISSN: 1871-403X

JOURNAL ARTICLE

McQuigg M, Brown JE, Broom JI, Laws RA, Reckles JPD, Noble PA, Kumar S, McCombie EL, Lean MEJ, Lyons GF, Mongia S, Frost GS, Quinn MF, Barth JH, Haynes SM, Finer N, Haslam DW, Ross HM, Hole DJ, Radziwonik Set al., 2008, Engaging patients, clinicians and health funders in weight management: the Counterweight Programme, 5th Heelsum International Workshop, Publisher: OXFORD UNIV PRESS, Pages: I79-I86, ISSN: 0263-2136

CONFERENCE PAPER

McQuigg M, Brown JE, Broom JI, Laws RA, Reckless JP, Noble PA, Kumar S, McCombie EL, Lean ME, Lyons GF, Mongia S, Frost GS, Quinn MF, Barth JH, Haynes SM, Finer N, Haslam DW, Ross HM, Hole DJ, Radziwonik Set al., 2008, Engaging patients, clinicians and health funders in weight management: the Counterweight Programme, Vol: 25 Suppl 1, Pages: i79-i86, ISSN: 1460-2229

JOURNAL ARTICLE

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