Imperial College London

ProfessorGaryFrost

Faculty of MedicineDepartment of Medicine

Chair in Nutrition and Dietetics
 
 
 
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Contact

 

+44 (0)20 3313 8037g.frost Website

 
 
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Location

 

Commonwealth BiuldingHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

342 results found

Otway DT, Frost G, Johnston JD, 2009, CIRCADIAN RHYTHMICITY INMURINE PRE-ADIPOCYTE AND ADIPOCYTE CELLS, CHRONOBIOLOGY INTERNATIONAL, Vol: 26, Pages: 1340-1354, ISSN: 0742-0528

JOURNAL ARTICLE

Philippou E, Bovill-Taylor C, Rajkumar C, Vampa ML, Ntatsaki E, Brynes AE, Hickson M, Frost GSet al., 2009, Preliminary report: the effect of a 6-month dietary glycemic index manipulation in addition to healthy eating advice and weight loss on arterial compliance and 24-hour ambulatory blood pressure in men: a pilot study, METABOLISM-CLINICAL AND EXPERIMENTAL, Vol: 58, Pages: 1703-1708, ISSN: 0026-0495

JOURNAL ARTICLE

Philippou E, Bovill-Taylor C, Rajkumar C, Vampa ML, Ntatsaki E, Brynes AE, Hickson M, Frost GSet al., 2009, Preliminary report: the effect of a 6-month dietary glycemic index manipulation in addition to healthy eating advice and weight loss on arterial compliance and 24-hour ambulatory blood pressure in men: a pilot study, Vol: 58, Pages: 1703-1708, ISSN: 1532-8600

JOURNAL ARTICLE

Philippou E, Neary NM, Chaudhri O, Brynes AE, Dornhorst A, Leeds AR, Hickson M, Frost GSet al., 2009, The Effect of Dietary Glycemic Index on Weight Maintenance in Overweight Subjects: A Pilot Study, OBESITY, Vol: 17, Pages: 396-401, ISSN: 1930-7381

JOURNAL ARTICLE

Philippou E, Neary NM, Chaudhri O, Brynes AE, Dornhorst A, Leeds AR, Hickson M, Frost GSet al., 2009, The effect of dietary glycemic index on weight maintenance in overweight subjects: a pilot study, Vol: 17, Pages: 396-401, ISSN: 1930-7381

JOURNAL ARTICLE

Barratt R, Frost G, Millward DJ, Truby Het al., 2008, A randomised controlled trial investigating the effect of an intensive lifestyle intervention v. standard care in adults with type 2 diabetes immediately after initiating insulin therapy, BRITISH JOURNAL OF NUTRITION, Vol: 99, Pages: 1025-1031, ISSN: 0007-1145

JOURNAL ARTICLE

Barratt R, Frost G, O'Boyle A, Millward J, Truby Het al., 2008, Use of sibutramine to assist obese women with weight loss can be successful in dietitian-led clinics: another tool in the dietitian's toolbox, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 21, Pages: 248-255, ISSN: 0952-3871

JOURNAL ARTICLE

Barratt R, Frost G, O'Boyle A, Millward J, Truby Het al., 2008, Use of sibutramine to assist obese women with weight loss can be successful in dietitian-led clinics: another tool in the dietitian's toolbox (vol 21, pg 248, 2008), JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 21, Pages: 525-525, ISSN: 0952-3871

JOURNAL ARTICLE

Calder PC, Albers R, Antoine JM, Blum S, Bourdet-Sicard R, Ferns GA, Folkerts G, Friedmann PS, Frost GS, Guarner F, Løvik M, Macfarlane S, Meyer PD, M'Rabet L, Serafini M, Van Eden W, Van Loo J, Vas Dias W, Vidry S, Winklhofer-Roob BM, Zhao Jet al., 2008, Nutrition and inflammatory processes, Proceedings of the Nutrition Society, Vol: 67, ISSN: 0029-6651

JOURNAL ARTICLE

Counterweight Project Team, 2008, Evaluation of the Counterweight Programme for obesity management in primary care: a starting point for continuous improvement., Br J Gen Pract, Vol: 58, Pages: 548-554, ISSN: 0960-1643

BACKGROUND: Evaluation for obesity management in primary care is limited, and successful outcomes are from intensive clinical trials in hospital settings. AIM: To determine to what extent measures of success seen in intensive clinical trials can be achieved in routine primary care. Primary outcome measures were weight change and percentage of patients achieving >or=5% loss at 12 and 24 months. DESIGN OF STUDY: Prospective evaluation of a new continuous improvement model for weight management in primary care. SETTING: Primary care, UK. METHOD: Primary care practice nurses from 65 UK general practices delivered interventions to 1906 patients with body mass index (BMI)>or=30 kg/m2 or>or=28 kg/m2 with obesity-related comorbidities. RESULTS: Mean baseline weight was 101.2 kg (BMI 37.1 kg/m2); 25% of patients had BMI>or=40 kg/m2 and 74% had >or=1 major obesity-related comorbidity. At final data capture 1419 patients were in the programme for >or=12 months, and 825 for >or=24 months. Mean weight change in those who attended and had data at 12 months (n=642) was -3.0 kg (95% CI=-3.5 to -2.4 kg) and at 24 months (n=357) was -2.3 kg (95% CI=-3.2 to -1.4 kg). Among attenders at specific time-points, 30.7% had maintained weight loss of >or=5% at 12 months, and 31.9% at 24 months. A total of 761 (54%) of all 1419 patients who had been enrolled in the programme for >12 months provided data at or beyond 12 months. CONCLUSION: This intervention achieves and maintains clinically valuable weight loss within routine primary care.

JOURNAL ARTICLE

Jadin L, Wu X, Ding H, Frost GI, Onclinx C, Triggs-Raine B, Flamion Bet al., 2008, Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX?, FASEB J, Vol: 22, Pages: 4316-4326

The metabolism of hyaluronan (HA) relies on HA synthases and hyaluronidases, among which hyaluronidase-1 (HYAL1) and -2 (HYAL2) have been proposed as key actors. Congenital HYAL1 deficiency leads to mucopolysaccharidosis IX (MPS IX), a rare lysosomal storage disorder characterized by joint abnormalities. Knowledge of HYAL2 is limited. This protein displays weak in vitro hyaluronidase activity and acts as a receptor for oncogenic ovine retroviruses. We have generated HYAL2-deficient mice through a conditional Cre-lox system. Hyal2(-/-) mice are viable and fertile. They exhibit localized congenital defects in frontonasal and vertebral bone formation and suffer from mild thrombocytopenia and chronic, possibly intravascular, hemolysis. In addition, Hyal2(-/-) mice display 10-fold increases in plasma levels of HA and 2-fold increases in plasma hyaluronidase activity. Globally, there is no HA accumulation in tissues, including bones, but liver sinusoidal cells seem overloaded with undigested HA. Taken together, these elements demonstrate for the first time that murine HYAL2 has a physiological activity in vivo that is relevant for craniovertebral bone formation, maintenance of plasma HA concentrations, and erythrocyte and platelet homeostasis. In addition, the viability of HYAL2-deficient mice raises the possibility that a similar defect, defining a new MPS disorder, exists in humans.

JOURNAL ARTICLE

Lansink M, van Laere KM, Rouws CH, Frost Get al., 2008, Administration of a new diabetes-specific enteral formula significantly improves 24 hour glucose profile in diabetic patients, 67th Annual Meeting of the American-Diabetes-Association, Publisher: AMER DIABETES ASSOC, Pages: A468-A468, ISSN: 0012-1797

CONFERENCE PAPER

McQuigg M, Broom JI, Laws RA, Reckless JPD, Noble PA, Kumar S, McCombie EL, Lean MEJ, Lyons GF, Frost GS, Quinn MF, Barth JH, Haynes SM, Finer N, Haslam DW, Ross HMet al., 2008, Tricks and tools for the primary care provider - The Counterweight Programme: a continuous improvement methodology model of weight management in UK primary care, 16th European Congress on Obesity, Publisher: NATURE PUBLISHING GROUP, Pages: S6-S6, ISSN: 0307-0565

CONFERENCE PAPER

McQuigg M, Brown JE, Broom J, Laws RA, Reckless JPD, Noble PA, Kumar S, McCombie EL, Lean MEJ, Lyons FG, Frost GS, Quinn MF, Barth JH, Haynes SM, Finer N, Haslam DW, Ross HM, Hole DJ, Radziwonik Set al., 2008, The Counterweight programme: Prevalence of CVD risk factors by body mass index and the impact of 10% weight change, OBESITY RESEARCH & CLINICAL PRACTICE, Vol: 2, Pages: 15-27, ISSN: 1871-403X

JOURNAL ARTICLE

McQuigg M, Brown JE, Broom JI, Laws RA, Reckles JPD, Noble PA, Kumar S, McCombie EL, Lean MEJ, Lyons GF, Mongia S, Frost GS, Quinn MF, Barth JH, Haynes SM, Finer N, Haslam DW, Ross HM, Hole DJ, Radziwonik Set al., 2008, Engaging patients, clinicians and health funders in weight management: the Counterweight Programme, 5th Heelsum International Workshop, Publisher: OXFORD UNIV PRESS, Pages: I79-I86, ISSN: 0263-2136

CONFERENCE PAPER

McQuigg M, Brown JE, Broom JI, Laws RA, Reckless JP, Noble PA, Kumar S, McCombie EL, Lean ME, Lyons GF, Mongia S, Frost GS, Quinn MF, Barth JH, Haynes SM, Finer N, Haslam DW, Ross HM, Hole DJ, Radziwonik Set al., 2008, Engaging patients, clinicians and health funders in weight management: the Counterweight Programme, Vol: 25 Suppl 1, Pages: i79-i86, ISSN: 1460-2229

JOURNAL ARTICLE

Mcgough C, Wedlake L, Baldwin C, Hackett C, Norman AR, Blake P, Harrington K, Tait D, Khoo V, Frost G, Andreyev HJNet al., 2008, Clinical trial: normal diet vs. partial replacement with oral E028 formula for the prevention of gastrointestinal toxicity in cancer patients undergoing pelvic radiotherapy, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 27, Pages: 1132-1139, ISSN: 0269-2813

JOURNAL ARTICLE

Moore C, Frost G, Griffin B, Lovegrove J, Sanders T, Jebb Set al., 2008, Impact of the Amount and Composition of Dietary Fat and Carbohydrate on Body Weight, Waist and Fat Measures, Annual Scientific Meeting of the Obesity-Society, Publisher: NATURE PUBLISHING GROUP, Pages: S300-S300, ISSN: 1930-7381

CONFERENCE PAPER

Philippou E, McGowan BMC, Brynes AE, Dornhorst A, Leeds AR, Frost GSet al., 2008, The effect of a 12-week low glycaemic index diet on heart disease risk factors and 24 h glycaemic response in healthy middle-aged volunteers at risk of heart disease: a pilot study, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 62, Pages: 145-149, ISSN: 0954-3007

JOURNAL ARTICLE

Wolever TMS, Brand-Miller JC, Abernethy J, Astrup A, Atkinson F, Axelsen M, Bjorck I, Brighenti F, Brown R, Brynes A, Casiraghi MC, Cazaubiel M, Dahlqvist L, Delport E, Denyer GS, Erba D, Frost G, Granfeldt Y, Hampton S, Hart VA, Hatonen KA, Henry CJ, Hertzler S, Hull S, Jerling J, Johnston KL, Lightowler H, Mann N, Morgan L, Panlasigui LN, Pelkman C, Perry T, Pfeiffer AFH, Pieters M, Ramdath DD, Ramsingh RT, Robert SD, Robinson C, Sarkkinen E, Scazzina F, Sison DCD, Sloth B, Staniforth J, Tapola N, Valsta LM, Verkooijen I, Weickert MO, Weseler AR, Wilkie P, Zhang Jet al., 2008, Measuring the glycemic index of foods: interlaboratory study, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 87, Pages: 247S-257S, ISSN: 0002-9165

JOURNAL ARTICLE

Wong MCY, Lee WTK, Wong JSY, Frost G, Lodge Jet al., 2008, An approach towards method development for untargeted urinary metabolite profiling in metabonomic research using UPLC/QToF MS, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, Vol: 871, Pages: 341-348, ISSN: 1570-0232

JOURNAL ARTICLE

, 2008, Influence of body mass index on prescribing costs and potential cost savings of a weight management programme in primary care, Journal of Health Services Research & Policy, Vol: 13, Pages: 158-166, ISSN: 1355-8196

JOURNAL ARTICLE

Brynes AE, Frost GS, 2007, Increased sucrose intake is not associated with a change in glucose or insulin sensitivity in people with type 2 diabetes, INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, Vol: 58, Pages: 644-651, ISSN: 0963-7486

JOURNAL ARTICLE

Frost G, Masters K, King C, Kelly M, Hasan U, Heavens P, White R, Stanford Jet al., 2007, A new method of energy prescription to improve weight loss, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 20, Pages: 152-156, ISSN: 0952-3871

JOURNAL ARTICLE

Grace C, Begum R, Subhani S, Frost G, Greenhalgh T, Kopelman Pet al., 2007, Understanding roadblocks to physical activity participation in a UK South Asian community: cultural and religious perspectives, 15th European Congress on Obesity, Publisher: NATURE PUBLISHING GROUP, Pages: S194-S194, ISSN: 0307-0565

CONFERENCE PAPER

Grace C, Begumt R, Subhani S, Frost G, Greenhalgh T, Kopelman Pet al., 2007, 'Fate depends on deeds': community and religious perspectives on diabetes prevention in a British Bangladeshi population, DIABETIC MEDICINE, Vol: 24, Pages: 27-27, ISSN: 0742-3071

JOURNAL ARTICLE

Jebb SA, Frost G, Griffin B, Lovegrove J, Moore C, Sanders T, Williams Cet al., 2007, The RISCK study: Testing the impact of the amount and type of dietary fat and carbohydrate on metabolic risk, Nutrition Bulletin, Vol: 32, Pages: 154-156, ISSN: 1471-9827

JOURNAL ARTICLE

Jesudason DR, Monteiro MP, McGowan BMC, Neary NM, Park AJ, Philippou E, Small CJ, Frost GS, Ghatei MA, Bloom SRet al., 2007, Low-dose pancreatic polypeptide inhibits food intake in man, BRITISH JOURNAL OF NUTRITION, Vol: 97, Pages: 426-429, ISSN: 0007-1145

JOURNAL ARTICLE

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