Imperial College London

ProfessorGaryFrost

Faculty of MedicineDepartment of Medicine

Chair in Nutrition and Dietetics
 
 
 
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Contact

 

+44 (0)20 3313 8037g.frost Website

 
 
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Location

 

Commonwealth BiuldingHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

342 results found

Kelly SAM, Summerbell CD, Brynes A, Whittaker V, Frost Get al., 2007, Wholegrain cereals for coronary heart disease, COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN: 1469-493X

JOURNAL ARTICLE

Martin NM, Small CJ, Lee JL, Ellis S, Dhillo WS, Smith KL, Kong WM, Frost GS, Bloom SRet al., 2007, Low-dose oral tri-iodothyronine does not directly increase food intake in man, DIABETES OBESITY & METABOLISM, Vol: 9, Pages: 435-437, ISSN: 1462-8902

JOURNAL ARTICLE

McGough C, Baidwint C, Hackett C, Wedlake L, Norman A, Frost G, Blake P, Tai D, Khoo V, Harrington K, Andreyev HJNet al., 2007, A randomised controlled trial of elemental diet during pelvic radiotherapy, CLINICAL ONCOLOGY, Vol: 19, Pages: S11-S11, ISSN: 0936-6555

JOURNAL ARTICLE

McGough C, Wedlake L, Hackett C, Norman A, Frost G, Blake P, Tait D, Khoo V, Harrington K, Andreyev HJNet al., 2007, Use of simple biological markers to monitor gastrointestinal toxicity during pelvic radiotherapy, CLINICAL ONCOLOGY, Vol: 19, Pages: S39-S39, ISSN: 0936-6555

JOURNAL ARTICLE

Milton JE, Briche B, Brown IJ, Hickson M, Robertson CE, Frost GSet al., 2007, Relationship of glycaemic index with cardiovascular risk factors: analysis of the National Diet and Nutrition Survey for people aged 65 and older, PUBLIC HEALTH NUTRITION, Vol: 10, Pages: 1321-1335, ISSN: 1368-9800

JOURNAL ARTICLE

Milton JE, Sananthanan CS, Patterson M, Ghatei MA, Bloom SR, Frost GSet al., 2007, Glucagon-like peptide-1 (7-36) amide response to low versus high glycaemic index preloads in overweight subjects with and without type II diabetes mellitus, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 61, Pages: 1364-1372, ISSN: 0954-3007

JOURNAL ARTICLE

Moore C, Gitau R, Frost GS, Griffin BA, Jebb SA, Sanders TA, Lovegrove JAet al., 2007, Strategy to alter the amount and composition of dietary carbohydrate and fat in free-living individuals participating in the RISCK trial, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 66, Pages: 86A-86A, ISSN: 0029-6651

JOURNAL ARTICLE

Mosdol A, Witte DR, Frost G, Marmot MG, Brunner EJet al., 2007, Dietary glycemic index and glycemic load are associated with high-density-lipoprotein cholesterol at baseline but not with increased risk of diabetes in the Whitehall II study, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 86, Pages: 988-994, ISSN: 0002-9165

JOURNAL ARTICLE

Nematy M, Brynes AE, Hornick PI, Patterson M, Ghatei MA, Bloom SR, Brett SJ, Frost GSet al., 2007, Postprandial ghrelin suppression is exaggerated following major surgery; implications for nutritional recovery, Nutrition & Metabolism, Vol: 4, ISSN: 1743-7075

JOURNAL ARTICLE

Philippou E, Neary NM, Chaudhri OB, Brynes AE, Dornhorst A, Leeds AR, Hickson M, Frost GSet al., 2007, Modest improvements in weight maintenance on a low-glycaemic index (G1) diet following weight loss in overweight and obese subjects, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 66, Pages: 75A-75A, ISSN: 0029-6651

JOURNAL ARTICLE

So P-W, Yu W-S, Kuo Y-T, Wasserfall C, Goldstone AP, Bell JD, Frost Get al., 2007, Impact of Resistant Starch on Body Fat Patterning and Central Appetite Regulation, PLOS ONE, Vol: 2, ISSN: 1932-6203

JOURNAL ARTICLE

Wong MCY, Feldmann H, Frost G, Lodge Jet al., 2007, Nutritional metabonomics: optimisation for general serum metabolic profiling using ultraperformance liquid chromatography (UPLC) coupled with quadrupole orthogonal acceleration time-of-flight, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 66, Pages: 110A-110A, ISSN: 0029-6651

JOURNAL ARTICLE

Baldwin C, McGough C, Norman AR, Frost GS, Cunningham DC, Andreyev HJNet al., 2006, Failure of dietetic referral in patients with gastrointestinal cancer and weight loss, EUROPEAN JOURNAL OF CANCER, Vol: 42, Pages: 2504-2509, ISSN: 0959-8049

JOURNAL ARTICLE

McGough C, Baldwin C, Norman A, Frost G, Blake P, Tait D, Khoo V, Harrington K, Andreyev HJNet al., 2006, Is supplementation with elemental diet feasible in patients undergoing pelvic radiotherapy?, CLINICAL NUTRITION, Vol: 25, Pages: 109-116, ISSN: 0261-5614

JOURNAL ARTICLE

McGough C, Peacock N, Hackett C, Baldwin C, Norman A, Frost G, Blake P, Tait D, Khoo V, Harrington K, Whelan K, Andreyev HJNet al., 2006, Taste preferences for oral nutrition supplements in patients before and after pelvic radiotherapy: A double-blind controlled study, CLINICAL NUTRITION, Vol: 25, Pages: 906-912, ISSN: 0261-5614

JOURNAL ARTICLE

Mead A, Van Goor A, Keightley H, Fox K, Frost Get al., 2006, Dietary improvements and impact on weight reduction in patients attending a cardiac prevention and rehabilitation programme: A longitudinal study, Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: B M J PUBLISHING GROUP, Pages: A55-A56, ISSN: 1355-6037

CONFERENCE PAPER

Nematy M, Brynes AE, Hornick PI, Brett SJ, Frost GSet al., 2006, Postprandial ghrelin suppression is exaggerated following major surgery; implications for nutritional recovery., PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 65, Pages: 63A-63A, ISSN: 0029-6651

JOURNAL ARTICLE

Nematy M, Hickson M, Brynes AE, Charles PJ, Frost GSet al., 2006, Appetite controlling gut hormone release during acute exacerbation of chronic obstructive pulmonary disease, Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), Publisher: B M J PUBLISHING GROUP, Pages: II87-II87, ISSN: 0040-6376

CONFERENCE PAPER

Nematy M, Hickson M, Brynes AE, Ruxton CHS, Frost GSet al., 2006, Vulnerable patients with a fractured neck of femur: nutritional status and support in hospital, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 19, Pages: 209-218, ISSN: 0952-3871

JOURNAL ARTICLE

Nematy M, O'Flynn JE, Wandrag L, Brynes AE, Brett SJ, Patterson M, Ghatei MA, Bloom SR, Frost GSet al., 2006, Changes in appetite related gut hormones in intensive care unit patients: a pilot cohort study, CRITICAL CARE, Vol: 10, ISSN: 1466-609X

JOURNAL ARTICLE

Nematy M, O'Flynn JE, Wandrag L, Brynes AE, Brett SJ, Patterson M, Ghatei MA, Bloom SR, Frost GSet al., 2006, Changes in appetite related gut hormones in intensive care unit patients: a pilot cohort study, Critical care (London, England), Vol: 10

METHODS: Sixteen ICU patients (60 +/- 4.7 years, body mass index (BMI) 28.1 +/- 1.7 kg/m2 (mean +/- standard error of the mean)) underwent fasting blood sample collections on days 1, 3, 5, 14, 21 and 28 of their stay at Hammersmith and Charing Cross Hospitals. Changes in appetite and biochemical and anthropometric markers of nutritional status were recorded. A comparison was made to a group of 36 healthy volunteers matched for age and BMI (54.3 +/- 2.9 years, p = 0.3; BMI 25.8 +/- 0.8 kg/m2 p = 0.2). RESULTS: Compared to healthy subjects, ICU patients exhibited a significantly lower level of ghrelin (day one 297.8 +/- 76.3 versus 827.2 +/- 78.7 pmol/l, p < 0.001) during their stay in the ICU. This tended to rise to the normal level during the last three weeks of hospital stay. Conversely, ICU patients showed a significantly higher level of PYY (day one 31.5 +/- 9.6 versus 11.3 +/- 1.0 pmol/l, p < 0.05) throughout their stay in the ICU and on the ward, with a downward trend to the normal level during the last three weeks of stay. CONCLUSIONS: Results from our study show high levels of PYY and low levels of ghrelin in ICU patients compared to healthy controls. There appears to be a relationship between the level of these gut hormones and nutritional intake. INTRODUCTION: The nutritional status of patients in the intensive care unit (ICU) appears to decline not only during their stay in the ICU but also after discharge from the ICU. Recent evidence suggests that gut released peptides, such as ghrelin and peptide YY (PYY) regulate the initiation and termination of meals and could play a role in the altered eating behaviour of sick patients. The aim of this study was to assess the patterns of ghrelin and PYY levels during the stay of ICU patients in hospital.

JOURNAL ARTICLE

Nematy M, Powell CA, Brynes AE, Pearse M, Patterson M, Ghatei MA, Bloom SR, Frost GSet al., 2006, Peptide YY (PYY) is increased in elderly patients with femoral neck fractures: A prospective cohort study, JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, Vol: 30, Pages: 530-531, ISSN: 0148-6071

JOURNAL ARTICLE

Patel AD, Stanley SA, Murphy KG, Frost GS, Gardiner JV, Kent AS, White NE, Ghatei MA, Bloorn SRet al., 2006, Ghrelin stimulates insulin-induced glucose uptake in adipocytes, REGULATORY PEPTIDES, Vol: 134, Pages: 17-22, ISSN: 0167-0115

JOURNAL ARTICLE

Philippou E, McGowan B, Brynes AE, Dornhorst A, Frost GSet al., 2006, The effect of a 12-week low-glycaemic index diet on heart disease risk factors and 24 h glucose profile in healthy middle-aged volunteers at risk of heart disease: a pilot study., PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 65, Pages: 59A-59A, ISSN: 0029-6651

JOURNAL ARTICLE

Philippou E, Milton JE, Brynes AE, Frost GSet al., 2006, An exploration into the proportion of carbohydrate used in the calculation of diet glycaemic index (GI) for which GI values are published or estimated., PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 65, Pages: 59A-59A, ISSN: 0029-6651

JOURNAL ARTICLE

Thomas EL, Brynes AE, Hamilton G, Patel N, Spong A, Goldin RD, Frost G, Bell JD, Taylor-Robinson SDet al., 2006, Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease, WORLD JOURNAL OF GASTROENTEROLOGY, Vol: 12, Pages: 5813-5819, ISSN: 1007-9327

JOURNAL ARTICLE

Wright L, Hickson M, Frost G, 2006, Eating together is important: using a dining room in an acute elderly medical ward increases energy intake, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 19, Pages: 23-26, ISSN: 0952-3871

JOURNAL ARTICLE

Wynne K, Park AJ, Small CJ, Meeran K, Ghatei MA, Frost GS, Bloom SRet al., 2006, Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial, INTERNATIONAL JOURNAL OF OBESITY, Vol: 30, Pages: 1729-1736, ISSN: 0307-0565

JOURNAL ARTICLE

Barratt R, Millward J, Truby H, Frost Get al., 2005, Invesitgation into the effects of initiating insulin therapy in type 2 diabetes, 65th Annual Meeting of the American-Diabetes-Association, Publisher: AMER DIABETES ASSOC, Pages: A166-A166, ISSN: 0012-1797

CONFERENCE PAPER

Barratt R, Millward J, Truby H, Frost Get al., 2005, Comparison of weight loss rates in patients who are overweight or have type 2 diabetes treated with lifestyle intervention or sibutramine, 65th Annual Meeting of the American-Diabetes-Association, Publisher: AMER DIABETES ASSOC, Pages: A660-A660, ISSN: 0012-1797

CONFERENCE PAPER

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