Imperial College London

ProfessorGaryFrost

Faculty of MedicineDepartment of Medicine

Chair in Nutrition and Dietetics
 
 
 
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Contact

 

+44 (0)20 3313 8037g.frost Website

 
 
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Location

 

Commonwealth BiuldingHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fiamoncini:2017:10.1152/ajpgi.00157.2017,
author = {Fiamoncini, J and Yiorkas, AM and Gedrich, K and Rundle, M and Alsters, SI and Roeselers, G and van, den Broek TJ and Clavel, T and Lagkouvardos, I and Wopereis, S and Frost, G and van, Ommen B and Blakemore, AI and Daniel, H},
doi = {10.1152/ajpgi.00157.2017},
journal = {Am J Physiol Gastrointest Liver Physiol},
pages = {G300--G312},
title = {Determinants of postprandial plasma bile acid kinetics in human volunteers.},
url = {http://dx.doi.org/10.1152/ajpgi.00157.2017},
volume = {313},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Bile acids (BA) are signaling molecules with a wide range of biological effects, also identified among the most responsive plasma metabolites in the postprandial state. We here describe this response to different dietary challenges and report on key determinants linked to its interindividual variability. Healthy men and women (n = 72, 62 ± 8 yr, mean ± SE) were enrolled into a 12-wk weight loss intervention. All subjects underwent an oral glucose tolerance test and a mixed-meal tolerance test before and after the intervention. BA were quantified in plasma by liquid chromatography-tandem mass spectrometry combined with whole genome exome sequencing and fecal microbiota profiling. Considering the average response of all 72 subjects, no effect of the successful weight loss intervention was found on plasma BA profiles. Fasting and postprandial BA profiles revealed high interindividual variability, and three main patterns in postprandial BA response were identified using multivariate analysis. Although the women enrolled were postmenopausal, effects of sex difference in BA response were evident. Exome data revealed the contribution of preselected genes to the observed interindividual variability. In particular, a variant in the SLCO1A2 gene, encoding the small intestinal BA transporter organic anion-transporting polypeptide-1A2 (OATP1A2), was associated with delayed postprandial BA increases. Fecal microbiota analysis did not reveal evidence for a significant influence of bacterial diversity and/or composition on plasma BA profiles. The analysis of plasma BA profiles in response to two different dietary challenges revealed a high interindividual variability, which was mainly determined by genetics and sex difference of host with minimal effects of the microbiota.NEW & NOTEWORTHY Considering the average response of all 72 subjects, no effect of the successful weight loss intervention was found on plasma bile acid (BA) profiles. Despite high interindividu
AU - Fiamoncini,J
AU - Yiorkas,AM
AU - Gedrich,K
AU - Rundle,M
AU - Alsters,SI
AU - Roeselers,G
AU - van,den Broek TJ
AU - Clavel,T
AU - Lagkouvardos,I
AU - Wopereis,S
AU - Frost,G
AU - van,Ommen B
AU - Blakemore,AI
AU - Daniel,H
DO - 10.1152/ajpgi.00157.2017
EP - 312
PY - 2017///
SP - 300
TI - Determinants of postprandial plasma bile acid kinetics in human volunteers.
T2 - Am J Physiol Gastrointest Liver Physiol
UR - http://dx.doi.org/10.1152/ajpgi.00157.2017
UR - https://www.ncbi.nlm.nih.gov/pubmed/28663304
VL - 313
ER -