Imperial College London

ProfessorGeorgeHanna

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Surgical Sciences and Head of Division
 
 
 
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Contact

 

+44 (0)20 3312 2125g.hanna

 
 
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Assistant

 

Ms Caroline Hurley +44 (0)20 3312 2124

 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

386 results found

Harris-Birtill D, Singh M, Zhou YU, Shah A, Gallina M, Cass A, Bamber J, Hanna G, Elson DSet al., Gold Nanorod Reshaping using a Continuous Wave Laser, Bio-Nano-Photonics Symposium

CONFERENCE PAPER

Nabavi E, Singh M, Zhou Y, Gallina M, Zhao H, Ma D, Cass A, Hanna G, Elson DSet al., Preliminary studies of targeted NIR photothermal therapy of human oesophageal adenocarcinoma in mice using multifunctional GNRs, British Medical Laser Association Conference

CONFERENCE PAPER

Singh M, Harris-Birtill D, Gallina M, Hanna G, Elson DSet al., Application of Gold Nanorods for Photothermal Effect in Upper Gastrointestinal Cancer Tissue, International Surgical Congress of the Association of Surgeons of Great Britain and Ireland

CONFERENCE PAPER

Singh M, Nabavi E, Zhou Y, Gallina M, Zhao H, Ma D, Cass A, Hanna G, Elson DSet al., Application of Gold Nanoparticles for Photothermal Therapy of Upper Gastrointestinal Adenocarcinoma, Bio-Nano-Photonics Symposium

CONFERENCE PAPER

Singh M, Nabavi E, Zhou Y, Zhao H, Ma D, Cass A, Hanna G, Elson DSet al., Application of Gold Nanorods in Cancer Theranostics (plenary presentation winner), Society for Surgery of the Alimentary Tract Annual Meeting, 31st Annual SSAT Residents and Fellows Research Conference

CONFERENCE PAPER

Acharya A, Markar SR, Ni M, Hanna GBet al., 2017, Biomarkers of acute appendicitis: systematic review and cost-benefit trade-off analysis, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol: 31, Pages: 1022-1031, ISSN: 0930-2794

JOURNAL ARTICLE

Boshier PR, Huddy JR, Zaninotto G, Hanna GBet al., 2017, Dumping syndrome after esophagectomy: a systematic review of the literature, DISEASES OF THE ESOPHAGUS, Vol: 30, ISSN: 1442-2050

JOURNAL ARTICLE

Bouras G, Markar SR, Burns EM, Huddy JR, Bottle A, Athanasiou T, Darzi A, Hanna GBet al., 2017, The psychological impact of symptoms related to esophagogastric cancer resection presenting in primary care: A national linked database study, EJSO, Vol: 43, Pages: 454-460, ISSN: 0748-7983

JOURNAL ARTICLE

Faiz O, Hanna GB, 2017, Understanding Administrative Data, ANNALS OF SURGERY, Vol: 265, Pages: E29-E29, ISSN: 0003-4932

JOURNAL ARTICLE

Faiz O, Hanna GB, 2017, Understanding Administrative Data., Ann Surg, Vol: 265

JOURNAL ARTICLE

Markar SR, Mackenzie H, Mikhail S, Mughal M, Preston SR, Maynard ND, Faiz O, Hanna GBet al., 2017, Surgical resection of hepatic metastases from gastric cancer: outcomes from national series in England, GASTRIC CANCER, Vol: 20, Pages: 379-386, ISSN: 1436-3291

JOURNAL ARTICLE

Markar SR, Noordman BJ, Mackenzie H, Findlay JM, Boshier PR, Ni M, Steyerberg EW, van der Gaast A, Hulshof MCCM, Maynard N, Henegouwen MIVB, Wijnhoven BPL, Reynolds JV, Van Lanschot JJB, Hanna GBet al., 2017, Multimodality treatment for esophageal adenocarcinoma: multi-center propensity-score matched study, ANNALS OF ONCOLOGY, Vol: 28, Pages: 519-527, ISSN: 0923-7534

JOURNAL ARTICLE

Penna M, Hompes R, Arnold S, Wynn G, Austin R, Warusavitarne J, Moran B, Hanna GB, Mortensen NJ, Tekkis PPet al., 2017, Transanal Total Mesorectal Excision International Registry Results of the First 720 Cases, ANNALS OF SURGERY, Vol: 266, Pages: 111-117, ISSN: 0003-4932

JOURNAL ARTICLE

Abbassi-Ghadi N, Golf O, Kumar S, Antonowicz S, McKenzie JS, Huang J, Strittmatter N, Kudo H, Jones EA, Veselkov K, Goldin R, Takats Z, Hanna GBet al., 2016, Imaging of Esophageal Lymph Node Metastases by Desorption Electrospray Ionization Mass Spectrometry, CANCER RESEARCH, Vol: 76, Pages: 5647-5656, ISSN: 0008-5472

JOURNAL ARTICLE

Abbassi-Ghadi N, Jones EA, Gomez-Romero M, Golf O, Kumar S, Huang J, Kudo H, Goldin RD, Hanna GB, Takats Zet al., 2016, A Comparison of DESI-MS and LC-MS for the Lipidomic Profiling of Human Cancer Tissue, JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol: 27, Pages: 255-264, ISSN: 1044-0305

JOURNAL ARTICLE

Acharya A, Markar S, Matar M, Ni M, Hanna Get al., 2016, Use of Tumour Markers in Oesophago-Gastric Cancers: Surgeon Perceptions and Cost-Benefit Trade-off Analysis, BRITISH JOURNAL OF SURGERY, Vol: 103, Pages: 52-52, ISSN: 0007-1323

JOURNAL ARTICLE

Acharya A, Markar SR, Wiggins H, Wiggins T, Huddy J, Hanna GBet al., 2016, Is surgical preadmission an underused opportunity in HIV?, LANCET HIV, Vol: 3, Pages: E459-E460, ISSN: 2352-3018

JOURNAL ARTICLE

Anderson O, Carr R, Harbinson M, Hanna GBet al., 2016, Development and validation of a lipase nasogastric tube position test, BMJ OPEN GASTROENTEROLOGY, Vol: 3, ISSN: 2054-4774

JOURNAL ARTICLE

Anderson O, Hanna GB, 2016, Effectiveness of the CareCentre (R) at improving contact precautions: randomized simulation and clinical evaluations, JOURNAL OF HOSPITAL INFECTION, Vol: 92, Pages: 332-336, ISSN: 0195-6701

JOURNAL ARTICLE

Antonowicz S, Kumar S, Wiggins T, Markar SR, Hanna GBet al., 2016, Diagnostic Metabolomic Blood Tests for Endoluminal Gastrointestinal Cancer-A Systematic Review and Assessment of Quality, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 25, Pages: 6-15, ISSN: 1055-9965

JOURNAL ARTICLE

Borsci S, Buckle P, Hanna GB, 2016, Why you need to include human factors in clinical and empirical studies of in vitro point of care devices? Review and future perspectives, EXPERT REVIEW OF MEDICAL DEVICES, Vol: 13, Pages: 405-416, ISSN: 1743-4440

JOURNAL ARTICLE

Bouras G, Markar SR, Burns EM, Mackenzie HA, Bottle A, Athanasiou T, Hanna GB, Darzi Aet al., 2016, Linked Hospital and Primary Care Database Analysis of the Incidence and Impact of Psychiatric Morbidity Following Gastrointestinal Cancer Surgery in England, ANNALS OF SURGERY, Vol: 264, Pages: 93-99, ISSN: 0003-4932

JOURNAL ARTICLE

Chadwick G, Riley S, Hardwick RH, Crosby T, Hoare J, Hanna G, Greenaway K, Varagunam M, Cromwell DA, Groene Oet al., 2016, Population-based cohort study of the management and survival of patients with early-stage oesophageal adenocarcinoma in England, BRITISH JOURNAL OF SURGERY, Vol: 103, Pages: 544-552, ISSN: 0007-1323

JOURNAL ARTICLE

Clancy NT, Teare J, Hanna GB, Elson DSet al., 2016, Flexible multimode endoscope for tissue reflectance and autofluorescence hyperspectral imaging

© OSA 2016. A dual reflectance and autofluorescence spectral imaging probe compatible with the biopsy channels of standard flexible endoscopes is demonstrated. Spatially-resolved haemoglobin and autofluorescent signals from porcine bowel were obtained in vivo.

CONFERENCE PAPER

Deijen CL, Velthuis S, Tsai A, Mavroveli S, de Lange-de Klerk ESM, Sietses C, Tuynman JB, Lacy AM, Hanna GB, Bonjer HJet al., 2016, COLOR III: a multicentre randomised clinical trial comparing transanal TME versus laparoscopic TME for mid and low rectal cancer, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol: 30, Pages: 3210-3215, ISSN: 0930-2794

JOURNAL ARTICLE

Foster JD, Ewings P, Falk S, Cooper EJ, Roach H, West NP, Williams-Yesson BA, Hanna GB, Francis NKet al., 2016, Surgical timing after chemoradiotherapy for rectal cancer, analysis of technique (STARRCAT): results of a feasibility multi-centre randomized controlled trial, TECHNIQUES IN COLOPROCTOLOGY, Vol: 20, Pages: 683-693, ISSN: 1123-6337

JOURNAL ARTICLE

Foster JD, Miskovic D, Allison AS, Conti JA, Ockrim J, Cooper EJ, Hanna GB, Francis NKet al., 2016, Application of objective clinical human reliability analysis (OCHRA) in assessment of technical performance in laparoscopic rectal cancer surgery, TECHNIQUES IN COLOPROCTOLOGY, Vol: 20, Pages: 361-367, ISSN: 1123-6337

JOURNAL ARTICLE

Hamaoui K, Gowers S, Boutelle M, Cook TH, Hanna G, Darzi A, Smith R, Dorling A, Papalois Vet al., 2016, Organ Pretreatment With Cytotopic Endothelial Localizing Peptides to Ameliorate Microvascular Thrombosis and Perfusion Deficits in Ex Vivo Renal Hemoreperfusion Models, TRANSPLANTATION, Vol: 100, Pages: E128-E139, ISSN: 0041-1337

JOURNAL ARTICLE

Hamaoui K, Gowers S, Boutelle M, Cook TH, Hanna G, Darzi A, Smith R, Dorling A, Papalois Vet al., 2016, Organ Pretreatment With Cytotopic Endothelial Localizing Peptides to Ameliorate Microvascular Thrombosis and Perfusion Deficits in Ex Vivo Renal Hemoreperfusion Models., Transplantation, Vol: 100, Pages: e128-e139

BACKGROUND: Hypothermic machine organ perfusion (HMP) offers opportunity to manipulate grafts with pharmacological agents prior to transplantation. Pretreating organs with novel cytotopic anticoagulant peptides that localize to endothelial cell membranes could ameliorate microvascular thrombotic sequelae posttransplantation. We describe experiments testing thrombalexin (TLN), a novel cell binding thrombin inhibitor, using porcine and unused human kidneys in a series of ex vivo normothermic hemoreperfusion models. METHODS: Thirty-eight porcine kidneys were used. Control kidneys underwent pretreatment via HMP with either unmodified perfusion solution (n = 15) or solution with inactive-TLN (absent anticoagulant effect, n = 4). Test kidneys were perfused with TLN-treated solution (n = 19). All kidneys then underwent hemoreperfusion. Two unused human kidneys underwent a similar protocol. RESULTS: Hypothermic machine perfusion pretreatment facilitated delivery and tethering of TLN in the organ microvasculature. Hemoreperfusion challenge demonstrated improved perfusion in TLN-treated kidneys compared with controls: 26.4% superior flow (30.6 vs. 23.1 mL/min per 100 g, P = 0.019) and 28.9% higher perfusion flow indices (0.43 vs. 0.32 mL/min per 100 g mm Hg, P = 0.049). Orthogonal polarization spectral imaging demonstrated superior microvascular capillary perfusion in TLN-treated organs versus controls (9.1 vs 2.8 pl/s per mm, P = 0.021). Rapid-sampling microdialysis for cortical [lactate] as a marker of tissue ischemia/metabolism detected lower levels in TLN-treated kidneys. Perfusate analysis demonstrated reduced fibrin generation in TLN-treated kidneys correlating with perfusion data. CONCLUSIONS: Our data suggest that HMP graft pretreatment with cytotopic anticoagulants is feasible and ameliorates perfusion deficits seen in ex vivo hemoreperfusion models. There is potential for further development and application of this translational strategy to deliver locally active an

JOURNAL ARTICLE

Hamaoui K, Gowers S, Damji S, Rogers M, Leong CL, Hanna G, Darzi A, Boutelle M, Papalois Vet al., 2016, Rapid sampling microdialysis as a novel tool for parenchyma assessment during static cold storage and hypothermic machine perfusion in a translational ex vivo porcine kidney model, JOURNAL OF SURGICAL RESEARCH, Vol: 200, Pages: 332-345, ISSN: 0022-4804

JOURNAL ARTICLE

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