Imperial College London
Alternate

ProfessorGeorgeHanna

Faculty of Medicine, Department of Surgery & Cancer

Head of Department of Surgery and Cancer
 
 
 
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Contact

 

+44 (0)20 7594 3396g.hanna

 
 
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Assistant

 

Ms Aoibheann Byrne +44 (0)20 7594 3396

 
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Location

 

Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Goh:2020:2020/2930347,
author = {Goh, YM and Antonowicz, S and Boshier, P and Hanna, G},
doi = {2020/2930347},
journal = {Oxidative Medicine and Cellular Longevity},
pages = {1--13},
title = {Metabolic biomarkers of squamous cell carcinoma of the aerodigestive tract: a systematic review and quality assessment},
url = {http://dx.doi.org/10.1155/2020/2930347},
volume = {2020},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction. Aerodigestive squamous cell carcinomas (ASCC) constitute a major source of global cancer deaths. Patients typically present with advanced, incurable disease, so new means of detecting early disease are a research priority. Metabolite quantitation is amenable to point-of-care analysis and can be performed in ASCC surrogates such as breath and saliva. The purpose of this systematic review is to summarise progress of ASCC metabolomic studies, with an emphasis on the critical appraisal of methodological quality and reporting. Method. A systematic online literature search was performed to identify studies reporting metabolic biomarkers of ASCC. This review was conducted in accordance with the recommendations of the Cochrane Library and MOOSE guidelines. Results. Thirty studies comprising 2117 patients were included in the review. All publications represented phase-I biomarker discovery studies, and none validated their findings in an independent cohort. There was heterogeneity in study design and methodological and reporting quality. Sensitivities and specificities were higher in oesophageal and head and neck squamous cell carcinomas compared to those in lung squamous cell carcinoma. The metabolic phenotypes of these cancers were similar, as was the kinetics of metabolite groups when comparing blood, tissue, and breath/saliva concentrations. Deregulation of amino acid metabolism was the most frequently reported theme. Conclusion. Metabolite analysis has shown promising diagnostic performance, especially for oesophageal and head and neck ASCC subtypes, which are phenotypically similar. However, shortcomings in study design have led to inconsistencies between studies. To support future studies and ultimately clinical adoption, these limitations are discussed.
AU  - Goh,YM
AU  - Antonowicz,S
AU  - Boshier,P
AU  - Hanna,G
DO  - 2020/2930347
EP  - 13
PY  - 2020///
SN  - 1942-0900
SP  - 1
TI  - Metabolic biomarkers of squamous cell carcinoma of the aerodigestive tract: a systematic review and quality assessment
T2  - Oxidative Medicine and Cellular Longevity
UR  - http://dx.doi.org/10.1155/2020/2930347
UR  - https://www.hindawi.com/journals/omcl/2020/2930347/
UR  - http://hdl.handle.net/10044/1/77292
VL  - 2020
ER  -
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