Imperial College London
Alternate

ProfessorGeorgeHanna

Faculty of Medicine, Department of Surgery & Cancer

Head of Department of Surgery and Cancer
 
 
 
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Contact

 

+44 (0)20 7594 3396g.hanna

 
 
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Assistant

 

Ms Aoibheann Byrne +44 (0)20 7594 3396

 
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Location

 

Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Halliday:2020:10.1007/s11605-020-04881-3,
author = {Halliday, LJ and Doganay, E and Wynter-Blyth, VA and Hanna, GB and Moorthy, K},
doi = {10.1007/s11605-020-04881-3},
journal = {Journal of Gastrointestinal Surgery},
pages = {2733--2741},
title = {The impact of prehabilitation on post-operative outcomes in oesophageal cancer surgery: a propensity score matched comparison},
url = {http://dx.doi.org/10.1007/s11605-020-04881-3},
volume = {25},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundPatients undergoing oesophageal cancer surgery are often frail with a high risk of post-operative complications. Prehabilitation has been shown to reduce post-operative complications in specific patient populations but evidence in oesophageal cancer patients is inconclusive.MethodsBetween January 2016 and April 2019, all patients with resectable oesophageal cancer who underwent curative treatment at a specialist tertiary centre participated in a personalised, home-based, multimodal prehabilitation programme. Post-operative complications and hospital stay in this group were compared to a control sample. Propensity score matching was used to control for differences in baseline characteristics.ResultsSeventy-two patients who completed prehabilitation and 39 control patients were studied; following propensity score matching, there were 38 subjects in each group. In comparison to matched controls, patients in the prehabilitation group had a lower incidence of post-operative pneumonia (prehabilitation = 26%; control = 66%; p = 0.001) and a shorter length of stay (prehabilitation = median 10 days, IQR 8–17 days; control = median 13 days, IQR 11–20 days; p = 0.018). On multivariate regression analysis, participation in prehabilitation was associated with a 77% lower incidence of post-operative pneumonia (OR 0.23, 95% CI 0.09 to 0.55 p = 0.001). There was no significant difference in the incidence of overall complications or severe complications.ConclusionPrehabilitation was associated with a lower incidence of post-operative pneumonia and shorter hospital length of stay following oesophagectomy. This model of home based, personalised, and supervised prehabilitation is effective and relevant to centralised cancer services.
AU  - Halliday,LJ
AU  - Doganay,E
AU  - Wynter-Blyth,VA
AU  - Hanna,GB
AU  - Moorthy,K
DO  - 10.1007/s11605-020-04881-3
EP  - 2741
PY  - 2020///
SN  - 1091-255X
SP  - 2733
TI  - The impact of prehabilitation on post-operative outcomes in oesophageal cancer surgery: a propensity score matched comparison
T2  - Journal of Gastrointestinal Surgery
UR  - http://dx.doi.org/10.1007/s11605-020-04881-3
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000595357900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007/s11605-020-04881-3
UR  - http://hdl.handle.net/10044/1/98536
VL  - 25
ER  -
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