Imperial College London
Alternate

ProfessorGeorgeHanna

Faculty of Medicine, Department of Surgery & Cancer

Head of Department of Surgery and Cancer
 
 
 
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Contact

 

+44 (0)20 7594 3396g.hanna

 
 
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Assistant

 

Ms Aoibheann Byrne +44 (0)20 7594 3396

 
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Location

 

Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Anderson:2016:10.1136/bmjgast-2015-000064,
author = {Anderson, O and Carr, R and Harbinson, M and Hanna, GB},
doi = {10.1136/bmjgast-2015-000064},
journal = {BMJ Open Gastroenterology},
title = {Development and validation of a lipase nasogastric tube position test},
url = {http://dx.doi.org/10.1136/bmjgast-2015-000064},
volume = {2},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundNasogastric tube position should be checked every day by either aspirate pH or chest radiography to prevent fatal misplaced feeding into the lungs. Many patients do not have acidic gastric aspirates and require daily chest radiographs. We developed and validated a lipase test that was compatible with non-acidic gastric aspirates.MethodsWe conducted evaluations of diagnostic test accuracy at a teaching hospital in development and validation stages. Development: We collected gastric and lung aspirates from 34 consecutive patients. We measured pH and human gastric lipase activity in the laboratory. These data helped us develop the lipase test. Ingenza Ltd (Roslin, Scotland) created tributyrin-coated pH test paper, which human gastric lipase converted into butyric acid, thus correcting false negatives. Validation: We tested nasogastric feeding tube aspirates from 36 consecutive patients with pH and lipase tests, using chest radiography or trial by use as the reference standard.ResultsDevelopment: We demonstrated human gastric lipase activity in the non-acidic stomach aspirates. Validation: The accuracy of the lipase test (sensitivity 97.2%, specificity 100%) was significantly better than pH (sensitivity 65.7%, specificity 100%, p<0.05).ConclusionsWhen nasogastric tube stomach aspirates were not acidic and pH was falsely negative, the lipase test showed a true positive and was significantly more accurate.
AU  - Anderson,O
AU  - Carr,R
AU  - Harbinson,M
AU  - Hanna,GB
DO  - 10.1136/bmjgast-2015-000064
PY  - 2016///
SN  - 2054-4774
TI  - Development and validation of a lipase nasogastric tube position test
T2  - BMJ Open Gastroenterology
UR  - http://dx.doi.org/10.1136/bmjgast-2015-000064
UR  - http://hdl.handle.net/10044/1/28114
VL  - 2
ER  -
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