Imperial College London

DrGeraldLarrouy-Maumus

Faculty of Natural SciencesDepartment of Life Sciences

Lecturer in Molecular Microbiology
 
 
 
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Contact

 

+44 (0)20 7594 7463g.larrouy-maumus

 
 
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Location

 

3.42Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
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35 results found

Skovierova H, Larrouy-Maumus G, Pham H, Belanova M, Barilone N, DasGupta A, Mikusova K, Gicquel B, Gilleron M, Brennan PJ, Puzo G, Nigou J, Jackson Met al., 2010, Biosynthetic Origin of the Galactosamine Substituent of Arabinogalactan in Mycobacterium tuberculosis, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 285, Pages: 41348-41355, ISSN: 0021-9258

JOURNAL ARTICLE

Kaur D, Pham H, Larrouy-Maumus G, Rivière M, Vissa V, Guerin ME, Puzo G, Brennan PJ, Jackson Met al., 2009, Initiation of methylglucose lipopolysaccharide biosynthesis in mycobacteria., PLoS One, Vol: 4

BACKGROUND: Mycobacteria produce two unique families of cytoplasmic polymethylated polysaccharides -- the methylglucose lipopolysaccharides (MGLPs) and the methylmannose polysaccharides (MMPs) -- the physiological functions of which are still poorly defined. Towards defining the roles of these polysaccharides in mycobacterial physiology, we generated knock-out mutations of genes in their putative biosynthetic pathways. METHODOLOGY/PRINCIPAL FINDINGS: We report here on the characterization of the Rv1208 protein of Mycobacterium tuberculosis and its ortholog in Mycobacterium smegmatis (MSMEG_5084) as the enzymes responsible for the transfer of the first glucose residue of MGLPs. Disruption of MSMEG_5084 in M. smegmatis resulted in a dramatic decrease in MGLP synthesis directly attributable to the almost complete abolition of glucosyl-3-phosphoglycerate synthase activity in this strain. Synthesis of MGLPs in the mutant was restored upon complementation with wild-type copies of the Rv1208 gene from M. tuberculosis or MSMEG_5084 from M. smegmatis. CONCLUSIONS/SIGNIFICANCE: This is the first evidence linking Rv1208 to MGLP biosynthesis. Thus, the first step in the initiation of MGLP biosynthesis in mycobacteria has been defined, and subsequent steps can be inferred.

JOURNAL ARTICLE

Skovierova H, Larrouy-Maumus G, Zhang J, Kaur D, Barilone N, Kordulakova J, Gilleron M, Guadagnini S, Belanova M, Prevost M-C, Gicquel B, Puzo G, Chatterjee D, Brennan PJ, Nigou J, Jackson Met al., 2009, AftD, a novel essential arabinofuranosyltransferase from mycobacteria, GLYCOBIOLOGY, Vol: 19, Pages: 1235-1247, ISSN: 0959-6658

JOURNAL ARTICLE

Appelmelk BJ, den Dunnen J, Driessen NN, Ummels R, Pak M, Nigou J, Larrouy-Maumus G, Gurcha SS, Movahedzadeh F, Geurtsen J, Brown EJ, Smeets MME, Besra GS, Willemsen PTJ, Lowary TL, van Kooyk Y, Maaskant JJ, Stoker NG, van der Ley P, Puzo G, Vandenbroucke-Grauls CMJE, Wieland CW, van der Poll T, Geijtenbeek TBH, van der Sar AM, Bitter Wet al., 2008, The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction, CELLULAR MICROBIOLOGY, Vol: 10, Pages: 930-944, ISSN: 1462-5814

JOURNAL ARTICLE

Pitarque S, Larrouy-Maumus G, Payre B, Jackson M, Puzo G, Nigou Jet al., 2008, The immunomodulatory lipoglycans, lipoarabinomannan and lipomannan, are exposed at the mycobacterial cell surface, TUBERCULOSIS, Vol: 88, Pages: 560-565, ISSN: 1472-9792

JOURNAL ARTICLE

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